Tribochemical Component of Oxidative Stress Development when Implantating of Artificial Joints. Part 2. Oxidative and Antiproliferative Effect of Wear Debris of Orthopedic Materials



Cite item

Full Text

Abstract

Using modeling reaction with constant production of metal radical-generated wear debris it was determined increasing intensification of oxidative processes. Generated free radicals enabled to oxidize polymeric component of endoprostheses. Radical-generated wear debris significantly decreased the proliferative ability of human osteogenic cells. Inert ceramics particles showed antiprolifirative effect only in their high concentration. Those particles prevented growth
of osteogenic cells. Worsening in mechanical properties of polymeric implant components and disturbance of bone remodeling under radical-generated wear debris may be one of the causes of further development of implant loosening and its instability.

References

  1. Булгаков В.Г., Гаврюшенко Н.С., Цепалов В.Ф. Количественная оценка радикалообразующей способности частиц износа ортопедических сплавов //Перспектив. матер. - 2004. - N 3. - C. 49-54.
  2. Булгаков В.Г., Ильина В.К., Гаврюшенко Н.С. и др. Антипролиферативное действие радикалообразующих и инертных частиц износа ортопедических материалов и его ингибирование костным жиром //Перспектив. матер. - 2004. - N 6. - C. 36-42.
  3. Булгаков В.Г., Гаврюшенко Н.С., Шальнев А.Н., Цепалов В.Ф. Трибохимический компонент развития окислительного стресса при имплантации искусственных суставов. Часть I. Определение радикалообразующей способности частиц износа различных ортопедических материалов //Вестн. трвматол. ортопед. - 2010. - N 1. - С. 44-48.
  4. Евмененко Н.П., Гороховатский, Цепалов В.Ф. Исследование кинетики и механизма окисления кумола на окиси хрома //Нефтехимия. - 1971. - Т. 11, N 3. - С. 400-403.
  5. Фриденштейн Ф.Я. Клонирование стромальных клеток-предшественников //Методы культивирования клеток. - Л., 1988. - C. 257-265.
  6. Ciapetti G., Granchi D., Savarino L. et al. In vitro testing of the potential for orthopedic bone cements to cause apoptosis of osteoblast-like cells //Biomaterials. - 2002. - Vol. 23, N 2. - P. 617-627.
  7. Costa L., Jacobson K., Bracco P., Brach del Prever E.M. Oxidation of orthopaedic UHMWPE //Biomaterials. - 2002. - Vol. 23, N 7. - P. 1613-1624.
  8. Germain M.A., Hatton A., Williams S. et al. Comparison of the cytotoxicity of clinically relevant cobalt-chromium and alumina ceramic wear particles in vitro //Biomaterials. - 2003. - Vol. 24, N 3. - P. 469-479.
  9. Hirakawa K., Bauer T.W., Stulberg B.N., Wilde A.H. Comparison and quantitation of wear debris of failed total hip and total knee arthroplasty //J. Biomed. Mater. Res. - 1996. - Vol. 31, N 2. - P. 257-263.
  10. Jahan M.S., Wang C., Schwartz G., Davidson J.A. Combined chemical and mechanical effects on free radicals in UHMWPE joint during implantation //J. Biomed. Mater. Res. - 1991. - Vol. 25, N 8. - P. 1005-1017.
  11. Kwon S.Y., Lin T., Takei H. et al. Alterations in the adhesion behavior of osteoblasts by titanium particle loading: inhibitionof cell function and gene expression //Biorheology. - 2001. - Vol. 38, N 2-3. - P. 161-183.
  12. Meldrum R.D., Bloebaum R.D., Dorr L.D. Metal ion concentration in retrieved polyethylene total hip inserts and implications for artifactually high readings in tissue //J. Biomed. Mater. Res. - 1993. - Vol. 27, N 11. - P. 1349-1355.
  13. O'Connor D.T., Choi M.G., Kwon S.Y., Paul Sung K.L. New insight into the mechanism of hip prosthesis loosening: effect of titanium debris size on osteoblast function //J. Orthop. Res. - 2004. - Vol. 22, N 2. - P. 229-236.
  14. Ozmen I., Naziroglu M., Okutan R. Comparative study of antioxidant enzymes in tissues surrounding implant in rabbits //Cell Biochem. Funct. - 2006. - Vol. 24, N 3. - P. 275-281.
  15. Pioletti D.P., Takei H., Kwon S.Y. et al. The cytotoxic effect of titanium particles phagocytosed by osteoblasts //J. Biomed. Mater. Res. - 1999. - Vol. 46, N 3. - P. 399-407.
  16. Raimondi M.T., Vena P., Pietrabissa R. Quantative evaluation of the prosthetic head damage induce by mic-roscopic third-body particles in total hip replacement //J. Biomed. Mater. Res. - 2001. - Vol. 58, N 4. - P. 436-448.
  17. Soloviev A., Schwarz E.M., Darowish M., O'Keefe R.J. Sphingomyelinase mediates macrophage activation by titanium particles independent of phagocytosis: а role for free radicals, NFkappaB, and TNFalpha //J. Orthop. Res. - 2005. - Vol. 23, N 6. - P. 1258-1265.
  18. Stea S., Visentin M., Granchi D. et al. Apoptosis in periimplant tissue //Biomaterials. - 2000. - Vol. 21, N 13. - P. 1393-1398.
  19. Zhang Q., Kusaka Y., Sato K. et al. Differences in the extent of inflammation caused by intratracheal exposure to three ultrafine metals:role of free radicals //J. Toxicol. Environ. Health A. - 1998. - Vol. 53, N 6. - P. 423-438.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2010 Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77-76249 от 19.07.2019.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies