Influence of the process of grinding and anti-friction agents on the technological characteristics of the pharmaceutical substance of an antihelmint appointment based on the vinyl pyridine series copolymer

Relevance. The search for new anthelmintic agents with low toxicity and the absence of serious side effects is an urgent problem today. The vinylpyridine copolymer belongs to the V class of «Almost non-toxic» drugs according to the Hodge and Sterner toxicity scale, and to the results of studies it exerts a high anthelmintic activity. The identified unsatisfactory technological characteristics are a significant but solvable problem for the development of solid dosage forms based on a vinyl pyridine copolymer. Purpose. To study the effect of grinding and mixing processes, using special laboratory equipment and the influence of antifriction agents on the technological characteristics of the copolymer. Materials and methods. The substance is avinylpyridine copolymer. The copolymer was milled using a laboratory mill-mixer, ball and disk mills. Mixing was carried out using a V-shaped mixer and a cyclic laboratory mill. Particle size range and fractional composition were determined according to the methods described in Russia State Pharmacopoeia XIV edition (GMP.1.2.1.0009.15, GMP. 1.1.0015.15). The equipment used: MICROMED 1 VAR 3-20microscope, a digital camera with a «TOUPCAM» 9.0MP video eyepiece and «Toup View» control software, a set of sieves with mesh sizes 1.0; 0.3 and 0.2 mm respectfully. The effect of antifriction substances on the copolymer was studied using magnesium stearate, stearic acid, sodium stearyl fumarate, talc and colloidal silicon dioxide. Assessment of the technological characteristics of the mixtures was carried out according to standard methods described in Russia State Pharmacopoeia XIV edition (GMP.1.4.2.0016.15). The «ERWEKA GTL» powder flow tester was used, the angle of repose was measured using a goniometer, and the bulk density before and after compaction was determined using the «ERWEKA SWM» tester and the «CASIO FX-82ES PLUS» electronic calculator. Results. The usage of laboratory shredders and mixers independently did not give satisfactory results, as did the introduction of individual antifriction agents into the composition of the mixtures. Introduction of a combination of antifriction agents (talc and stearyl fumarate) into the experimental mixture as well as carrying out the grinding and mixing processes in a cyclic laboratory mill optimized the technological properties of the copolymer. Conclusions. The influence of grinding and mixing processes, using special laboratory equipment, and of antifriction agents on the technological characteristics of the copolymer was studied. Antifriction substances and equipment were selected and the technology of mixing and grinding processes for the further development of solid dosage forms was determined.

copolymer, anthelmintic effect, echinococcosis, antifriction agents, grinding, mixing, flowability, technological properties