Vol 3, No 5 (2015)

Until now, plants have been the main source of new drugs. Morus nigra, which con- tains a rich complex of biologically active substances necessary for an organism (vita- mins, anthocyanins, macro- and microele- ments, organic acids) is of great interest. We have conducted morphological and anatomical studies of stems of Morus nigra, identified the main diagnostic characters of the studied me- dicinal plants. Experimental studies have shown that the stems of Morus nigra are char- acterized by the presence of thick-walled epi- dermal cells with slightly convoluted walls and a large number of ordinary thick-walled fuzz.

The work is devoted to the review of the application of collagen and materials based on collagen in medicine and the pharmaceutical industry. We have taken into consideration the aspects of the use of “Collost” sterile bio- plastic collagen material in surgery and op- tions for further research areas of biomaterials on the basis of unreconstructed collagen.

We have carried out the analysis of antymicobacterial activity of PYATd10 dia- zinon derivative and dapsone. The capability of PYATd10 compound and dapsone drug to suppress the growth of M.lufu culture was studied by the method of serial dilutions. Vis- ual evaluation of inoculations in medium Shkolnikova showed that there was no growth of mycobacteria with PYATd10 concentration 128 µg/ml, while minimum suppressing con- centration of dapsone were equal to 32 µg/ml. Examining smears, colored according to Mu- rohashi, under the influence of PYATd10 ex- cipient and dapsone drug in the same concen- trations, we have revealed the decrease of my- cobacterial living forms content. A share of inviable bacteria decreased after the cultiva- tion intensification, but amounts to less than 35%. Thus, the PYATd10 compound exhibits antimycobacterial activity towards M. lufu, being slightly inferior to the dapsone compara- tive drug by this type of activity.

The article describes the problems of de- velopment of an algorithm for state service outsourcing. On the basis of the expert evalua- tions method we have revealed the priority of factors for evaluation of reasonability of in- volvement of outsorter-organization with state services rendering.

The article analyzes principal legal as- pects of medical products storage, appointed for medical and sanitary consequences of emergencies mitigation. We have revealed that nowadays there is a whole range of legal gaps and uncertainties in the regulation of medical products storage. We have also offered the ways for their solution.

Maintenance of the stock of medical prop- erty is an important strategic problem of Rus- sian Federation Armed Forces nowadays. In the course of plan upgrading and reforming of a stock there is a necessity for theoretical elaboration of price formation process and re- alization of drugs and medical products dis- charged from the stocks. The conducted anal- ysis of the requirements of current rules and regulations allowed the substantiation of the mechanism structure, which evaluates the price of drugs and medical products while formation, their keeping in a stock and refor- mation of medicinal property sets. We have created a model of price formation for drugs and medical products which are included into the medical property sets for theoretical sub- stantiation of the mentioned processes.The study conducted allowed not only structuring of the price formation mechanismof discharged property, but also to isolate the prospective directions of its realization. So, we have established that the drugs and medical products discharged from the stock may be of great interest for consumers due to the medical property offer in low (optimal) costs.

Pharmacy organizations are an element of regional pharmaceutical market infrastructure formation. They have different character and activity type, organizational and legal forms, types of properties. The revelation of the fea- tures of retail pharmaceutical market of Yaro- slavl oblast was the purpose of the study. The analysis of the data of regional department of Federal Service on Surveillance in Healthcare and Social Development of Russian Federa- tion in Yaroslavl oblast in the beginning of 2014 showed that there are 137 acting com- mercial entities, which have licenses for pharmaceutical activity. The region has 487pharmacy organizations which implement pharmaceutical activity of state (14.6%), mu- nicipal (7.4%), and private (78.0%) forms of ownership. Some companies function in Yaro- slavl (43.9%) and Rybinsk (22.4%) municipal district. The analysis of organization and legal forms revealed that 48.9% of pharmacy organ- izations are registered as ltd, 14.6% are state, and 14.2% are private entrepreneurs, public limited companies amount to 10.9%, the rest pharmacy organizations are included into mu- nicipal unitary enterprises and private limited companies - 7.39% and 4.1% corresponding- ly. The structure of retail market is represented by single pharmacy organizations (51.1%) as well as organizations joined into pharmacychains from two and more PO (48.9%). The share of commercial entities which include one PO amounted to 14.4% of all PO. Share of pharmacy chains (42.3%) which include from2 to 9 PO are 46.8% of all PO. Pharmacy chains, which have more than 9 retails spots amount to 6.6% of the total number of com- mercial entities. 38.8% of PO function within them. Pharmacy chains prevalence (42.3%), joined into 9 PO; pharmacy chains, which have more than 9 PO, and include state sector PO (14.6%) are the features of the regional market.

The article is devoted to basic life mile- stones of Professor, Doctor of Pharmaceutical Science, Honored Scientist of RussiaV.G. Belikov, who made a great contribution to the development of domestic pharmaceuti- cal education and science, more than 30 years headed the leading pharmaceutical institution of the country.