Vol 24, No 6 (2013)

Minimal change disease is a morphological basis for the most common type of childhood nephrotic syndrome sensitive to corticosteroid therapy. The paper considers the immunopathogenesis of the disease, as well as steroid, symptomatic, and immunosuppressive therapies.

The results of endoscopic diagnostic and treatment method were assessed in patients with locally advanced prostate cancer (PC) who had undergone radical prostatectomy (RPE). The investigation enrolled 65 patients diagnosed with Stage T1-T3 PC; After RPE, they were diagnosed as having complications, such as urethral and urethral cystoanastomotic strictures, artifacts at the anastomotic site, and scarring deformity of the bladder neck. Optimal treatment policy was defined in this category of patients.

The paper analyzes the epidemiology, pathogenesis, clinical picture, and pathogens of urogenital inflammatory diseases in the presence of HIV infection. Ir considers approaches to treating these patients in view of the toxicity of used drugs and their interaction with other medications,

In different periods after cholecystectomy, pain and dyspepsia (postcholecystectomic syndrome (PCES)) recommence in 5-40% of patients. The study of the biochemical aspects of the latter holds the greatest promise for the elaboration of diagnostic criteria for PCES.

The paper considers the etiological pattern of acute enteric infections (AEI) and microbiological diagnostic problems. An ecological classification of AEIs with their differentiation into anthroponoses, zoonoses, and sapronoses is proposed. The specific features of the mechanism of fecal-oral pathogen transmission are noted.

The recent study gives evidence that estrogens and estrogen receptors play an important role in colorectal cancerogenesis. The nuclear estrogen receptor ERß is predominantly expressed in the gastrointestinal tract, including colonic epithelium. It plays an important role in the proliferation and differentiation of normal colonic mucosa. Expression of ERß is selectively lost in human malignant colon tissue, leading to disruption of differentiation, reduction of apoptosis, malignant transformation of the colonic mucosa, poor prognosis of disease.

The paper considers the etiology, pathogenesis, diagnosis, and treatment of obstructive azoospermia. Particular emphasis is laid on morphological changes in testicular tissue, depending on the etiological factor of obstructive azoospermia and the level of obstruction. Data are given on the efficiency of treatment and testicular biopsy in this category of patients.

The results of endoscopic treatment options were assessed in 41 patients with obstructive complications after brachytherapy for Stage T1-T3 prostate cancer. The patients underwent interstitial radiotherapy. The efficiency of interventions for radiation damage to the urethra and prostate was analyzed.

How to choose optimal therapy continues to be discussed due to a wide range of pharmaceuticals used to treat premature ejaculation (PE). The purpose of this trial was to evaluate the efficiency of different treatment regimens in patients with PE in the presence or absence of erectile dysfunction and to assess long-term results.

The paper outlines the fundamentals of the pathogenesis, diagnosis, and treatment policy in intermittent vesicoureteral reflux in children. Using her clinical findings and long-term treatment results, the author justifies the use of an array of diagnostic methods and defines indications for the use of a number of treatment procedures for this pathological condition.

The mean concentration of fasting immunoreactive insulin and the mean basal level of glucose in polycystic ovary syndrome concurrent with euthyroidism and hypothyroidism increase by 1.5- and 1.5-1.7-fold, respectively. Reduced thyroid functioning is an additional unfavorable factor deteriorating the increased blood atherogenic potential and impaired glycemic profile.

Asthmatic patients are at increased risk of developing arterial hypertension. A combination of bronchial asthma and arterial hypertension has a significant prognostic value.