Farmaciya (Pharmacy)

Introduction. Currently, in accordance with the requirements of the Federal State Educational Standard for Vocational Education, curricula should provide for the implementation of individual projects by students of secondary vocational education. The article examines the importance and conditions for the development of students' project activities

Objective: to consider an individual project as a special form of organizing the activities of students studying at the Faculty of Medicine

Material and methods: The experience of working on an individual project in Moscow educational institutions was used: Universities “Synergy” and “Reaviz”, Medical College No.2. To obtain information, we used the results of a scientific literature search on search, information and library databases: CyberLeninka, ELibrary.ru, National Electronic Library (NEB), PubMed, molbiol.ru, MedLine the Cochrane Library, EMBASE, Global Health, RSCI, etc., by search queries: “individual project”, “project activity”, “student research activities”, etc. Next, the most important scientific articles on the topic of publication were selected

Results. Information about the history of individual projects in the learning process is presented. And also about their diversity and importance in the educational process. The problems that arise when introducing an “individual project” into the curriculum of secondary vocational education are analyzed. Possible solutions are proposed. The principles of the distribution of responsibility areas and the positional role of students in a team/group project are considered. As well as the opportunity to formalize the results of your work in a team as a separate individual project.

Conclusion. To improve the level of individual project execution, it is proposed:

• avoid assigning responsibility to one discipline and separate an individual project into an independent discipline or distribute responsibility across different disciplines;
• to do team/group projects with clearly defined areas of responsibility for each participant, as a result of which all students will have the opportunity to formalize the results of their work in a team as a separate individual project.

Introduction. Dracocephalum moldavica L. is an annual herbaceous plant of the Lamiaceae family. The above-ground part of this plant contains various biologically active substances – essential oil, flavonoids and their glycosides, phenolic acids, triterpenoids, steroids, lignans, anthocyanins, iridoids, polysaccharides, pectin substances. A method for obtaining a pharmaceutical substance in the form of a dry extract has been developed at VILAR. In vivo and in vitro experiments have shown that it has pronounced anti-inflammatory and gastroprotective activities, which may be promising for its further study. One of the main conditions for ensuring the quality of the developed substance is the solution of issues of standardization of the herb of the Moldavian dragonhead and the extract obtained from it.

Objective: To establish criteria of authenticity and quality indicators that allow for quality control of the herb of the Moldavian dragonhead.

Material and methods. The object of the study is dried Moldavian dragonhead herb, harvested in the North Caucasian branch of VILAR during the budding and flowering phases in 2018, in the Middle Volga branch of VILAR and in the VILAR experimental field during the flowering phase in 2020. The entire study was carried out in accordance with the general pharmacopoeial articles of the State Pharmacopoeia of the Russian Federation, XV edition.

Results. As a result of the studies, morphological and anatomical diagnostic features of the raw materials were established, a method for assessing authenticity by TLC with a standard sample of rosmarinic acid was developed, the nomenclature of numerical indicators and their norms were determined. For the quantitative assessment of biologically active substances, a method for determining the amount of phenolic compounds in terms of rosmarinic acid was developed and validated. Analysis of samples of experimental batches of Moldavian dragonhead herb made it possible to establish the standard content of phenolic compounds in terms of rosmarinic acid of at least 4%.

Conclusion. The obtained data allowed us to develop and formalize a normative document – a draft pharmacopoeial article “Moldavian dragonhead herb”.

Introduction. CAR-T cell therapy has proven to be an effective treatment for relapsed and refractory hematologic malignancies. However, its widespread adoption in Russia is hindered by high costs, complex regulatory procedures, and a limited number of specialized centers. Consequently, the feasibility of extemporaneous manufacturing as an alternative mechanism for CAR-T cell production to improve accessibility arises as a relevant question.

Objective. To analyze the feasibility and potential implementation of extemporaneous manufacturing of CAR-T cell products in Russia, identify necessary legislative changes, and assess the potential risks and benefits of this approach.

Results. Currently, CAR-T cells in Russia can be produced either as high-technology medicinal products, which require mandatory registration, or as individualized biomedical cell products, authorized by the Ministry of Health and available exclusively within the medical institutions where they were manufactured. An analysis of Russian legislation indicates that the recent precedent allowing pharmaceutical compounding of radiopharmaceutical medicinal products establishes a legal basis for potentially extending a similar approach to CAR-T cells. Potential benefits include improved accessibility, reduced costs, and the possibility of personalized manufacturing. However, implementation would require adapting regulations for pharmacy-compounded medicinal products, developing good compounding practice guidelines, establishing pharmacopoeial standards for cellular products, and creating mechanisms for quality control and biosafety assurance.

Conclusion. The introduction of extemporaneous CAR-T cell manufacturing in Russia could significantly enhance the accessibility of personalized cell therapy. However, successful implementation requires regulatory amendments, the establishment of a certification and oversight system, and the training of qualified professionals. Further research should focus on developing regulatory standards and conducting pilot projects to evaluate the feasibility of this approach.

Introduction. Maintaining cleanliness of pharmaceutical manufacturing facilities is a requirement of Good Manufacturing Practices (GMP). According to the GMP standards of the Russian Federation and the GMP standards of the Eurasian Economic Union, the procedure for using detergents and disinfectants, developed by the organization independently, must be based on microbiological control and ensure rotation of different types of preparations.

Objective: analysis of the trade names of disinfectants used at 4 enterprises for treating premises of different cleanliness classes from A to D was carried out.

Material and methods. The evaluation parameters were chosen: belonging of the active ingredient to one or another group according to the modern classification of disinfectants; country of origin; price range of the offer from open sources; scope of application and processing modes in accordance with the instructions for use.

Results. Despite the differences in the number of items in each pharmaceutical enterprise, it has been revealed that the drugs contain active substances of different chemical natures, ensuring the destruction of any microorganisms and preventing the development of their resistance. Combined disinfectants dominate the range of disinfectants used. More often, concentrates or solid forms are used to prepare working solutions, followed by antiseptics intended for sanitizing the hands of personnel and disinfecting small, hard-to-reach surfaces and equipment. Most disinfectants are domestic. The instructions for use of some drugs do not clearly state that they are intended for use in pharmaceutical or other drug manufacturing facilities. Prices for the studied titles published in open popular sources show significant fluctuations.

Conclusion. The analysis of the range of disinfectants used at four pharmaceutical manufacturing enterprises demonstrated the use of drugs of different groups according to the active ingredient, which allows for effective disinfection, development of individual treatment modes for rooms of purity classes A, B, C, D, while rotating drugs, as required by the GMP standard.

Introduction. Aging population, increasing prevalence of liver diseases, government initiatives to provide vaccines and growing awareness, lifestyle changes that lead to increase in diseases associated with this lifestyle, increased alcohol consumption and improper dietary habits are expected to drive the growth of the liver disease therapeutics market. In the Republic of Algeria, the majority of drugs in the pharmaceutical market are generics or imported drugs, including in hepatology.

The aim of the study is to determine the needs of the pharmaceutical market in the Republic of Algeria for the prevention and treatment of liver diseases in order to create a domestic drug.

Material and methods. The study was conducted by analyzing the assortment of drugs for the prevention and treatment of liver diseases in the pharmaceutical markets of the Republic of Algeria and the Russian Federation based on the data of national lists and registers of drugs. The selection of promising plant candidates was based on the analysis of scientific literature on the species used in Russian drugs, taking into account the biodiversity of the Mediterranean flora.

Results. Comparative analysis revealed significant differences. The market of the Republic of Algeria is dominated by imported antispasmodics (57%), which are the only herbal preparations, whereas the Russian market demonstrates a wide range of phytotherapeutic agents (21.2%).

Conclusion. The scarcity of herbal preparations for the treatment of liver diseases in the Republic of Algeria requires the development of new drugs. Three species of local plants – milk thistle, artichoke and rosemary – which have liver-protective properties, were selected as promising candidates.