Vol 72, No 1 (2023)

Introduction. Ensuring optimal consumption of selenium by the population is an urgent task of preventive medicine, the solution of which will prevent the development of many diseases.

Objective: to study the biological role and pharmacological effect of selenium and selenium-containing drugs on the human body.

Material and methods. The analysis and systematization of scientific literature data on the pharmacological effect of selenium and selenium-containing drugs on the human body has been carried out.

Results and discussion. Selenium deficiency is associated with a number of health disorders and an increased risk of death. At the same time, the danger of excessive intake of selenium into the body was noted. It is important to ensure safe compensation for selenium deficiency in the population.

Conclusion. A promising tool for eliminating selenium deficiency is the Russian “SELENBIO for women” complex. It contains organic selenium of plant origin in the form of L-selenocystine, which is effective and safe.

Introduction. Analysis of the pharmaceutical market shows that in the treatment of chronic prostatitis drugs containing Sabal palm fruit extract are used. During the research we developed a domestic analogue of the registered medicinal product containing this extract. In preparation of the regulatory documentation and registration dossier for the new drug, we carried out the research necessary for this purpose on the Sabal palm fruit, biologically active extract and soft gelatin capsules.

Objective of the study. Development and validation of the methodology for quantitative determination of triterpenoids and phytosterols in capsules containing Sabal palm fruit extract.

Material and methods. The objects of the study are pilot series of a medicinal product with the extract of palm Sabal fruit – soft gelatin capsules 160 mg/caps. and 320 mg/caps. The method underlying the determination of the sum of triterpenoids and phytosterols – differential spectrophotometry

Results and discussion. The pharmacological activity of Sabal palm fruit extract is associated with lipids, namely higher fatty acids, triterpenoids and phytosterols. The methodology of standardization of the new drug was developed taking into account their physico-chemical properties. The analysis provides alkaline hydrolysis, selective extraction of the unsaponifiable fraction, differential spectrophotometry after oxidation of sterols in the presence of sulfuric acid. The content of the analyzed substances in the drug: for dosage of 160 mg/caps. – not less than 5.5 mg/cup, for the dosage of 320 mg/cup. – not less than 11.0 mg/caps. in terms of β-amyrin.

Conclusion. The methods for quantitative determination of the sum of triterpenoids and phytosterols in a new drug preparation containing an extract of Sabal palm fruit have been developed, validated and tested. In the course of approbation of the method the norms of their quantitative content in the medicinal product were experimentally established. The method complies with all validation criteria, is characterized by ease of performance and can be used for standardization and quality control at all stages of industrial production of the medicinal product.

Introduction. The development of herbal medicines is an important part of the pharmaceutical industry. Among the common flavonoid-containing plants there are the herb of knotweed pepper, the herb of knotweed bird and the nettle. From these plants, a liquid extract was obtained for a hemostatic effect.

Objective of the study. To develop a gel technology from local plant raw materials liquid extract and study the microbiological purity.

Material and methods: the object of the study was a dental gel that meets the requirements of regulatory documents. Determination of microbiological purity was carried out in accordance with the methodology of the SP XI edition.

Results. The technology of dental gel from a liquid extract obtained on the basis of local vegetable raw materials was experimentally established.

Conclusion. The data on the substantiation of the composition, technology, the choice of the type and amount of preservative to stabilize the gel in the studied storage period are presented. Study of the antimicrobial, wound-healing properties of dental gel based on liquid extract was carried out.

Introduction. The consumer's perception of the quality of the pharmaceutical service provided to him is important for the operation of the pharmacy. A stable level of satisfaction and a repeating positive experience of visiting a pharmacy form the basis for the formation of loyalty, therefore, in order to achieve success, regular study and monitoring of these parameters is necessary.

Objective: To analyze the degree of satisfaction of the population of the Irkutsk region with the quality of pharmaceutical services.

Material and methods. Pharmacy organizations of the Irkutsk region were the basis for the study. We used a survey method (questionnaire). Data processing was carried out using MS Excel. In order to identify significant differences within the groups of respondents, a multivariate PERMANOVA analysis of variance was carried out.

Results. The factors influencing the choice of a pharmacy by consumers are studied, while differences in the answers of respondents within groups by age and social status are revealed. To assess the level of satisfaction, a certain set of criteria was used, each of which was evaluated by consumers on a five-point scale. For each of the criteria, the average score and the consumer satisfaction index (CSAT) were calculated. Weaknesses in the work of the pharmacy that affect the level of consumer satisfaction are identified.

Conclusion. Results of a study on regular monitoring of food and food quality. It is envisaged to conduct a report on the quality of pharmaceutical services, taking into account the discussed level of quality of services from the point of view of consumers.

Introduction. Medicinal hepatitis is one of the pathologies characteristic of modern times. The cause of the disease is taking medications without medical supervision and, on the other hand, an increase in the range of drugs with a hepatotoxic effect.

Purpose of the study. To study the antioxidant effect created at the Scientific Research Center of the Azerbaijan Medical University by Professor Kh.I. Gasanov of the complex compound (C8H12ON)2 [PdCl4], synthesized on the basis of palladium and mexidol.

Material and methods. To study its effect on a living organism, an experiment was conducted on 30 outbred white rats. The experimental animals were divided into 6 groups of 5 animals each.

Results and discussions. 3 days after the modeling of medicinal hepatitis in the liver tissue, a weakening of the antioxidant defense system was observed. The obtained results show that the model of medicinal hepatitis created using paracetamol was stable, and the concentration of markers of the antioxidant defense system in the homogenate continued to decrease, despite the 10th day after the creation of the pathological process. As a result of exposure to KSPM introduced into the body, the average concentration of markers of the antioxidant defense system in the liver homogenate increased significantly. There was also an increase in the concentration of PB-SH, the concentration of the internal group of the protein-SH, peroxidase activity, catalase activity and TAA.

Conclusion. It has been established that the drug increases the concentration of markers of the antioxidant defense system in the liver of white rats, created against the background of a hepatitis model. The effect of the synthesized biologically active substance depends on the time of its introduction into the body.