Vol 16, No 1 (2017)

The article is devoted to solving related problems Environmental Medicine, Ecology and practical health care, namely the study of the effects of exposure to environmental factors (chemical pollution, noise, vibration, exposure to electromagnetic fields, the effect of adverse climatic and weather conditions) on the human body and the development of environmentally induced disease . Timely diagnosis, prevention and treatment of diseases associated with exposure to environmental factors is one of the major challenges of modern health and development program "Environmental Medicine", the implementation of which is aimed at achieving active healthy human longevity

Biomarkers of aging - measurable parameters that reproducibly qualitative and quantitative changes with aging. Many agerelated pathologies are developing for a long time in a hidden form. The earlier the diagnosis and treatment - the more likely success. Biomarkers will evaluate the effectiveness of treatment, without waiting for the measurement of life span. Thus, the diagnostic biomarkers of aging have a great potential for early diagnosis and prognosis of chronic age-related diseases, as well as monitoring the effectiveness of prevention and treatment. The article describes the theory-oriented and omics biomarkers of aging. The aging process can be divided into the molecular, cellular and systemic (endocrine and immune). In each of these groups, there are several hypotheses of aging(for example,genetic, telomeric, free radical, replicative aging, immunosenescence, etc) based on which we can analyze the aging rate In connection with the reduction in the cost of modern high-performance methods for the study of biological molecules, a promising approach is the analysis of profiles of DNA, RNA, proteins and metabolites ("omics approach").

The paper presents the main modern concepts of a new direction - preventive medicine. Its purpose is described as the implementation of effective individual programs for prevention of development and progression of chronic diseases and age-related conditions. The paper also provides an overview of applied innovative diagnostic methods, individual prevention and treatment programs, based on peptidergic regulation.

Vertebral-basilar insufficiency has great medical-social importance: up to 80 % of all cases identified were ischemic strokes, the nature of its occurrence and of which up to 30 % are negative localization of the lesion in the vertebral-basilar vascular pool. The clinical manifestations of the patient appeal to neurologists (dizzy, headaches), to otorinolaringologa (cochleo-vestibular disorders according to the type of tinnitus and hearing loss), to psychologists and psychotherapists (psycho-emotional disorder, and disorder of sleep), etc.; the etiopathogenesis of the cerebral hemodynamics includes besides endovenousvertebrogenic compression of the vertebral arteries (actually the field of neurology) is joined by the problem of deterioration of the venous outflow, venous sinuses into the internal jugular vein and cranial vault are diploic veins through numerous emissary of skull to soft tissue of the head (which increasingly focused on in their research phlebologists), which consequently gives rise to a variety of medical tactics. For the period May 2016 through December 2016 in the Clinic, "the Residence of health and longevity GL MED" was treated 18 patients with vertebral-basilar insufficiency. All patients underwent a comprehensive examination, which included: a study of neuro-orthopedic status, Doppler ultrasound of the brachiocephalic arteries, ultrasound of the fixation structures of the cervical spine, neuroimaging techniques (CT, MRI). We used the methodology of revitalisation of the patients on the basis of proprioceptive neuro-muscular re-education (PNF) and comprehensive pharmacotherapy with Ginkgo biloba extract EGB761 (memoplant), horse chestnut extract venoplant (improves venous outflow), neuroplant. The methodology of revitalisation of the patients with vertebral-basilar insufficiency showed a high and persistent therapeutic effect, which was expressed in 10 patients in the transition from a progressive type of the disease to regredientes, in 4 patients from a progressive-regredientes to regredientes, while 4 patients remained progressive-regredientes type of the disease unchanged.

A comprehensive peptide research for 40 years in many species of various organisms allowed us to finally conclude that living world has common mechanism of peptide regulation of gene expression and protein biosynthesis. Short peptides (2-4 аmino acid residues) are able to penetrate into cell and its nucleus. Complementary interaction of short peptides with gene promoters seems to be a transcription regulatory signal. It induces expression of crucial genes and proteins. These peptide-DNA interactions stimulate functioning of various organs and increase organism resources up to species limit. Investigated short peptides induced specific changes in gene transcription in bacteria, plants, insects, amphibia, birds, mammals and humans, they normalized protein biosynthesis. It was accompanied by decrease in frequencies of tumor formations and increase of lifespan.

The article presents the analytical review of research carried out, including with the participation of the authors and devoted to the study of the mechanisms and reasons for the increasing prevalence weather dependent pathology in the context of climate change, as well as the development of approaches to the early diagnosis and personalized prevention of common weather dependent diseases of the circulatory system. Separately consider risk management issues of development of complications of this disease by studying the uptake of patients for emergency care (according to the Ambulance and medical assistance, emergency of A.S. Puchkov in Moscow), depending on weather conditions in the area of their residence. The correlation between the number of requests for emergency medical assistance on the occasion of aggravation of diseases of the circulatory system, respiratory and nervous system to weather conditions (performance ambient temperature, humidity and atmospheric pressure), varies in different seasons. Lately advanced research and scientific development in the direction of creating a personalized program non-drug prevention dependent on the weather diseases and creating conditions for an active healthy longevity in the population of Russia in the conditions of climate change.

The article is devoted to medical rehabilitation of patients with parodontal diseases with application of the parodontal pins, gingival plates and chewable tablets. As well as physiotherapy treatment with application of photodynamic therapy with gel Lamifaren. The results of a comprehensive examination, diagnosis, and treatment of 123 patients with chronic generalized parodontitis of moderate severity, the results of their research and conclusions. Developed methods of complex treatment of patients with chronic generalized parodontitis of moderate severity with the use of the parodontal pins, gingival plates and chewable tablets. The efficiency of complex treatment. There was a positive dynamics: the index of hygiene decreased by 39±0.2%, the index of bleeding on 47±0.05% and gingival index 39±0,05%. The effectiveness of the treatment in the control group was comprised of 11±0,11%, in the primary group 47±0,5%.

The manuscript is devoted to the problem of informative and communication technologies use in organization of primary medical care in patients with ischemic heart disease (IHD). We provide the results of modern “electronic” healthcare instruments use aiming to reform rehabilitation process in “patient-oriented” principles. The provided organizational and functional model includes electronic technology chart of rehabilitation, computerized decision support, remote monitoring of rehabilitation and secondary prevention measures, monitoring of functional criteria, effective internet-communications between the doctor and the patient. The study included 28 patients with ST-myocardial infarction in ambulatory rehabilitation period under the category of low/intermediate 6-months risk of fatal complications (mean GRACE score 92±12) with clinical affiliation to light (21.4%) and from mild to severe (78.6%) rehabilitation groups of ST-myocardial infarction. Observance of “patient-oriented” methods in the study was reached by: 1) execution of the informed consent by the patient; 2) extended consulting protocol with questionnairies filling; 3) collaborative decision making between the doctor and the patient with the help of “electronic” medicine instruments; 4) confidentiality compliance; 5) possibility of effective doctor-patient communications as part of internet communications. Authors showed that enlargement of informative and technical patients’ support and use of self-control methods in the system of remote rehabilitation care significantly promote the activity of patients and effectiveness of “doctor-patient” communications. Combination of regularly internet consulting with reasonable office consultations when using telemedicine data is the most optimal variant of ambulatory rehabilitation and prevention care.

Described the reasoning of a new methodology and methods of distribution of pupils into groups for physical exercise, taking into account the level of health and physical performance. It was established the greatest accuracy and information content of a technique "Quantitative express assessment of the physical health of children and adolescents" G.L. Apanasenko. It is proved that the level of health by G.L. Apanasenko correlate well with indicators of functional status and adaptation to physical activity of children. It is established the dependence of physical performance, level of physical activity, acute morbidity with level of physical health by the method of G.L. Apanasenko. The more the "amount" of health, the less chance of development and manifestation of the disease. Method G.L. Apanasenko enables to conduct primary screening of the quantitative determination of individual health of the schoolboys, not the presence or absence of acute or chronic diseases or defects of development.