Vol 54, No 4 (2005)

The essential issues of clinical and laboratory diagnosis, treatment and prevention of congenital syphilis are reviewed. Last decade the number of babies born with congenital syphilis increased significantly in Russia. Those women at highest risk for the disease seem to be alcohol and drug users, as well as those without antenatal care.

In the article the frequency of Cesarean section in the North-Western region of Russia is analysed. Reasons for widening of surgery indications, operative technics, prophylaxis of infectional processes in postoperative period, main problems of conducting of pregnacy in women with prior cesarean delivery are discussed.

This study was aimed to evaluate a new realtime nucleic acid sequence-based amplification (NASBA-Real- Time) assay for diagnosis of urogenital Chlamydia trachomatis infection. A total of 193 patients aged 16 to 42 (mean age, 22,8 years) were examined, with most of them having symptoms of urogenital infection. Cervical and urethral swabs from women and men, respectively, were investigated with the use of cell culture method, polymerase chain reaction (PCR) and NASBA- Real-Time. C. trachomatis infection was diagnosed in 29 patients (15 %): in 21 patients - by all the three methods, whereas 8 samples were culture negative. Sensitivity of PCR and NASBA- Real-Time methods were 100 %, cell culture method - 78,4 %. Negative predictive value of PCR and NASBA-Real-Time was found to be 100 %, and that of cell culture - 95,3 %. Specificity as well as positive predictive values of all the three methods equaled 100%. Thus, the new real-time NASBA-Real-Time assay was shown to be a very sensitive and specific test, which can be recommended as a confirmatory method for diagnosis of urogenital chlamydial infection.

There were analysed the results of treatment efficiency and compliance of Ferrum medication in pregnant women with anemia using non-ionic compounds Fe (III) — Ferlatum (1st group) and ionic compounds Fe (II)— Sorbiferdurules (2nd group). Compounds of Fe (III) were more compliant in treatment of anemia making Ferlatum the medication of choise in treatment of anemia during pregnancy.

Last years the attention of researchers is involved in studying of role of calcic homeostasis infringements in development of not only bone rarefication, but also osteoartrosis, arteriosclerosis, arterial hypertension, demention. Mentioned diseases, alongside with a bone rarefication, are the most frequently occured in persons of advanced age. The given pathology is offered for defining(determining) as «estrogen- deficiency diseases», «calcium-scarce»diseases. The definition of pathogenetic interrelation between metabolic infringements in postmenopause and the various somatic pathology arising during the given period of time still remains one of the actual problems. The purpose of the present research was studying frequency of occurrence, a degree of expressiveness of climacteric symptoms and extragenital diseases depending on level of MDBT at women with identical duration of estrogen deficiency conditions after the introduction in natural and surgical menopause. 120 women in the age of44-54 years old (mean age 52,5±0,4 y.o.) were examined and included in the 1st group of study, the Ilnd group consisted of 80 women after ovarioectomy in the age of 38-52 y.o. (mean age 46,2±2,3 y.o.). There were revealed that life quality of women who had entered in postmenopause after ovarioectomy was worse in comparison with life quality of women in natural postmenopause. The certain interrelation between degree of some climacteric symptoms expressiveness, intensity of painful syndrome in osteo-muscular system, prevalence of extragenitaldiseases and level of MDBT was revealed.

The functional property of interferon status was studied in 22 mothers and their full-term infants infected with Herpes Simplex Virus and Cytomegalovirus. The findings showed the necessity of interferon status definition in full-term infant for solving the questions about using interferon agent in the complex treatment of viral disease.

The authors have given the estimation of clnical efficiency of Miphepriston in the treatment of uterine fibroid. Miphepriston is steroid compounds and antigestagen. Its clnical efficiency is comparable with gonadothropine-antagonists, widely used in in the treatment of uterine fibroid. Miphepriston has a high level of compliance due to its minimal adverse effects

Based on firstly created Komi database of 1980- 1999 years, the authors analysed labor and delivery outcomes: total amount, newborns height and weight, Apgar score, term of pregnancy in dependence on seasonal and yearly changes. Received data testified that seasonal transformation of human organism in European North conditions along social-economic and medical factors have possible influence to conception, pregnancy and delivery outcomes.

The article dedicated by 150th anniversary of Nikolay Phenomenov has opened the contribution of this famous Russian obstetrician and gynecologists in development of operative obstetrics, using of aseptics methods in gynecology, founding of Kazan scientific obsteric-gynecological school, managing of Nadezdinskiy Maternity House in Saint-Petersburg

November 22-24, 2005 in St. Petersburg at the Research Institute of Obstetrics and Gynecology. BEFORE. Ott RAMS hosted the International Scientific Congress "Operative Gynecology - New Technologies dedicated to the 150th anniversary of Professor D.O. Ott.

The article presents literature review dedicated by problem of urine tract infections during pregnancy. There were analysed the changes of urine tract organs during pregnancy, problems of antibiotic resistance, the modem approaches to treatment in pregnant women. The peculiarities of pregnancy and labor and delivery in women with urine tract infections, newborns well-being were studied. There were shown the role of Canephrone in urine tract sanation, and its effects on fetus and newborn

There were summarized the results of discussion concerning problems of bioethics, deontology, patient’s rights and juridical resonsibility of obstetrician and gynecologists.