Vol 22, No 3 (2014)

Articles
ULTRASTRUCTURAL CHARACTERISTICS OF THE REMODELING VENTRICULAR ELECTRIC PATHWAYS BETWEEN CARDIOMYOCYTES AFTER THE INFLUENCE OF CHRONIC PRENATAL HYPOXIA IN EXPERIENCE
Petruk N.S., Tverdokhleb I.V.
Abstract
The aim of this work was to determine the influence of chronic prenatal hypoxia on remodeling of gap junctions in cardiomyocytes in rat ventricular myocardium at different stages of postnatal ontogeny. Chronic prenatal hypoxia to decline total and mean individual profile length of the gap junction per 100 μm intercalated disk in comparison with the norm, at 30 th day was decrease the amount of gap junctions per 100 μm intercalated disc in comparison of control level and caused predominantly violation build large gap junctions.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):7-16
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MORPHOLOGICAL CHANGES OF VASCULAR WALL AT DIFFERENT STAGES OF EXPERIMENTAL THROMBOSIS
Sushkov S.A., Nebilitsin Y.S., Samsonova I.V., Markautsan P.V.
Abstract
Objective. To study interactive structural changes of vascular wall at experimental modeling thrombosis of the inferior cava vein system deep veins. Thrombosis caused by ligation of external iliac vein and injection of thrombin (40 /kg) into femoral vein. At the outset thrombotic process causes local destruction of endotheliocytes plasmolemma and karyolemma. Clot compressive effect upon veinous wall blocks severe and rapid endothelium swelling. At 30-th min leucocytes appear in peripheral parts of clot and along the vein intima. Transendothelial leucocytes migration appears on the 60-th min, that more severe increase the endothelium damage and, as result, focal desquamation of these cells. By the 12-24 hours increase of collagen and elastic fibers was distinct registered in the intima.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):17-27
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ANALYSIS OF MORPHOLOGICAL AND FUNCTIONAL CHANGES OF PHYLOGENETICALLY DIFFERENT AREAS OF THE CEREBRAL CORTEX IN RATS
Ilicheva V.N., Shtemberg A.S.
Abstract
In experiment conducted on outbred white male rats, irradiated with a single dose of 1.0 Gy, morphological changes of neurocytes in neo- , archi- and paleocortex were analyzed within 18 months after the exposure. The obtained regression equations enable to count the time elapsed after irradiation, on the data of morphofunctional state of nerve cells in irradiated animals.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):28-32
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MOSAICISM OF HYALINE CARTILAGE: QUANTITATIVE MORPHOLOGICAL STUDY ON RABBIT ELBOW JOINT
Novochadov V.V., Alekseenko A.Y., Krylov P.A., Shuvalova E.Y.
Abstract
To study the heterogenecity of hyaline cartilage we have analyzed the tissues of elbow joint received from six intact Chinchilla rabbits. Classic histological assays, step-by-step scanning, and quantitative morphological analysis were performed. The revealed phenomenon at least concluded in an available of mosaic plots (microclusters), different from the environment of the numerical density of chondrocytes, structure and optical density of cartilage matrix. These microclusters took up to 40% of cartilage volume, they could be described as a polygon truncated pyramids with a diameter cross section about 60-100 microns near the basophil line and extending to 100-150 microns by superficial zone of the cartilage. The revealed phenomenon was matched to the biomechanics of the joints to provide for optimal redistribution of static and dynamic loads on the articular surface.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):33-39
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ACUTE INTESTINAL INFECTIONS IN CHILDREN. A NEW LOOK AT AN OLD PROBLEM
Lobzin Y.V., Anokhin V.A., Khaliullina S.V.
Abstract
The article presents an overview of modem ideas about the etiological structure, principles of diagnosis and therapy of acute intestinal infections in children. The authors comment on the features of the diagnosis and treatment of these patients, existing today in the domestic and foreign practice. As part of evidence-based medicine shows the efficacy of various drugs for the treatment of children with infectious diarrhea. The authors used the results of their research to substantiate their position in discussions on several issues of improving diagnostic and therapeutic approaches in working with patients with acute intestinal infections.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):40-47
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CLINICAL AND ENDOSCOPIC CHARACTERISTICS OF ACUTE EROSIVE-ULCEROUS PATHOLOGY OF THE UPPER GASTROINTESTINAL TRACT IN PATIENTS OF HEMORRHAGIC FEVER WITH RENAL SYNDROME, LEPTOSPIROSIS AND TULAREMIA
Maleyev V.V., Martynov V.A., Klochkov I.N.
Abstract
The article shows the results of endoscopic and morphological studies of pathology of the upper gastrointestinal tract (GIT) in 174 patients of both sexes with hemorrhagic fever with renal syndrome (HFRS), leptospirosis and tularemia. The high frequency of erosive and ulcerative and hemorrhagic changes in the gastrointestinal mucosa due to deep microcirculatory disorders. We found that changes of mucosa interrelated with leading clinical and laboratory parameters, severity and time of occurrence of the underlying disease. We considered variants of gastrointestinal pathology in connection with abdominal syndrome. The study showed associating defined erosive and ulcerative lesions of gastric and duodenal ulcer with Helicobacter pylori infection. We have established the optimal time for endoscopic examination - this is the first day of hospitalization. This allows you to quickly identify the erosive ulcerous pathology until complications carry out, to hold adequate correction of treatment and reduce the risk of bleeding, which greatly improves the prognosis of the disease.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):48-55
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INTERFERON GAMMA-CYTOKINE WITH ANTIVIRAL, IMMUNOMODULATORY AND ANTITUMOR ACTION
Sologub T.V., Tsvetkov V.V., Deeva E.G.
Abstract
Interferon gamma is a unique drug with anti-virus, anti-tumor and immunomodulatory activity. Thanks to the latter its quality interferon gamma was added to cytokines - regulators of immune responses. The study of this interesting cytokine can open up broad prospects for the treatment of patients not only with lymphoproliferative diseases, but patients with cancer and infectious diseases.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):56-60
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PSYCHOLOGICAL DISORDERS IN PATIENTS WITH VIRAL HEPATITIS
Raduto O.I.
Abstract
It reviewed the literature data on changes in the psycho-emotional status of patients with chronic viral hepatitis. Shown that chronic hepatitis have a significant effect on the mental state of patients, with the severity of psychological disorders depends on the clinical laboratory and morphological characteristics of the disease. The information about the observable signs of socio-psychological maladjustment, raising the level of anxiety, symptoms of depression in patients with chronic hepatitis. Shows a higher risk of contracting hepatitis B virus to patients in a psychiatric hospital. It confirmed the importance of timely diagnosis and correction of mental disorders in patients with chronic hepatitis, as well as the need to examine individual characteristics and mental abnormalities that may act as factors causing risk behavior in these patients.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):61-67
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BIOLOGY OF HUMAN DENDRITIC CELLS AND THEIR ROLE IN INFECTIOUS DISEASES
Tsvetkov V.V., Sologub T.V., Tokin I.I.
Abstract
Dendritic cells are a heterogeneous human population of professional antigen-presenting cells. They are known to play a critical role in the regulation of both innate and acquired immune response. The functional activity of dendritic cells depends on the action signals microenvironment. Of particular interest is the study of the role of dendritic cells in the pathogenesis of various infectious diseases in humans.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):68-74
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EPSTEIN-BARR VIRUS ROLE IN ONCOGENESIS
Shestakova I.V., Yushyuk N.D.
Abstract
We now recognize that the Epstein-Barr virus (EBV) plays a pivotal role in the development of some lymphomas and lymphoproliferative disorders that include B-cell, T-cell and NK-cell processes, and epithelial and mesenchymal tumors. While over recent years, EBV associated lymphomas are becoming increasingly recognized in patients without overt immunodeficiency. Improved understanding of the biology of these lymphomas and the role that EBV plays in their pathogenesis has paved the way for improved therapies targeted at critical signaling pathways as well as the development of novel cellular therapies. This review discusses the unique cytomorphology, clinical and immunophenotype signs and ancillary studies required to diagnose EBV-related neoplasms.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):75-86
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FEATURES COMMON CANCERS BASED TYPOLOGICAL PROPORTIONAL SAMPLE (ON MATERIALS NIZHNY NOVGOROD REGION)
Denisenko A.N., Kamaev I.A., Grib M.N., Podushkina I.V., Oreshina A.V.
Abstract
The article shows the levels and dynamics of morbidity and mortality, as well as geographical features of prevalence of cancer in the Nizhny Novgorod region in the 2010-2012 years. The necessity of forming a multi-level system of the population cancer care and the need for primary and secondary prevention of cancer are also shown.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):87-92
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THE COURSE OF PREGNANCY AND CHILDBIRTH TAKING INTO ACCOUNT MEDICAL ACTIVITY AND DISPENSARY SUPERVISION OF WOMEN
Kabochkin A.A.
Abstract
Results of sociological poll of 672 residents of Ryazan who had childbirth in the anamnesis are given in the article. Distribution of specific weight normal and pathological childbirth depending on the frequency of visit by respondents of female consultation with the preventive purpose to and during pregnancy is given. The results of an expert assessment of quality medical care for puerperants in such blocks as diagnostics, consultations of specialists, treatment and expertise of temporary disability are presented.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):93-97
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REGIONAL FEATURES OF RISK FACTORS IN THE ETIOLOGY OF BREAST CANCER
Schumova L.M., Denisenko A.N., Iordanskaya N.A.
Abstract
The article presents the incidence of breast cancer among women living in the Nizhny Novgorod region for the period from 2010 to 2012, given the medico-social characteristics of the patients, analyzed and evaluated risk factors for breast cancer, shows the need for primary and secondary prevention of this disease.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):98-102
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IP. PAVLOV’S STUDY OF HIGHER NERVOUS ACTIVITY
Kershbaum K., Chugunova E.I.
Abstract
A concept of conditioned reflexes developed by I.P. Pavlov played a key role in the developing of “higher nervous activity” approach. Higher nervous activity is regarded as a totality of neuro-physiologic processes involved in both conscious and subconscious information gathering and adjustment in humans.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):103-105
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THE EFFECT OF THE COMPLEX TREATMENT INVOLVING AFOBAZOL ON THE CONDITION OF THE IMMUNE SYSTEM OF PSORIASIS PATIENTS
Razumnaya F.G., Zarudy F.S., Kapuler O.M.
Abstract
The prescription of pscychopharmacological medications belonging to the group of benzimidazole derivatives has a positive effect during a complex treatment for psoriasis patients. It decreases the secretion of TNFa, IL-2, INFy cytokines changing the structure and the subpopulations of T-lymphocytes which leads to a more intensive decrease in immunoregulatory coefficient ОД4+/СД8+.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):106-113
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THE COMBINED OPERATIONS AT PATIENTS WITH MORBID OBESITY
Yudin V.A., Sazhin V.P., Melnikov A.A., Osipov V.V., Usachev I.A., Ivanov V.V., Melnikova I.A.
Abstract
The material of this work presents the problem of surgical treatment of patients with severe obesity. The assessment of the methods applied by authors in combined bariatric operations is given on the oun material.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):114-119
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INTRAARTERIAL REGIONAL INFUSION TRACT IN THE DIAGNOSIS AND TREATMENT OF ACUTE PANCREATITIS
Lazutkin M.V., Ivanusa S.Y., Tikhomirova O.E.
Abstract
The study used the results of the examination and treatment of 41 patients with acute pancreatitis who underwent endovascular catheterization of the celiac trunk, followed by intra-regional perfusion of the pancreas. The clinical results of intra-regional perfusion of the pancreas showed efficacy in the prevention of septic complications, progression of pancreatic necrosis in patients with aseptic forms of severe pancreatitis. Create intraarterial infusion tract allows multislice spiral computed tomography celiacography in order to increase the information content ray imaging zones destruction of the pancreas.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):120-125
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TOPOGRAFO-ANATOMICAL FEATURES OF LATERALLY LOCATED PERFORATING VEINS
Shvalb P.G., Shanaev I.N.
Abstract
This study was designed to review the topographic anatomy of perforating veins on the lateral aspect of the lower leg. Anatomic dissection was performed in 35 cadavers in two stages, subcutaneously and subfascially. Perforating veins were classified relative to the short saphenous vein and intermuscular septa.The results showed that there is aligment of the perforating veins according to the septa between the anterior and peroneal compartment and between the peroneal compartment and the posterior compartment. Most of the perforating veins did not correlate with the short saphenous vein. The most clinically significant perforators were located in the middle third on the lateral aspect of the lower leg.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):126-131
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DIFFERENCES IN THE SIZES OF CROWNS OF PRIMARY MOLARS AND PREMOLARS AND THEIR SOGNIFICANCE FOR THE CHOICE OF PREVENTIVE MEASURES AT THE SAGITTAL OCCLUSION DENTITION ANOMALIES
Nabatchikova L.P., Horoshilkina F.Y., Arman C., Armine C.
Abstract
We have reviewed the literature data about the mesial/distal dimensions of the crowns of the primary molars and premolars which replace them in both jaws. 126 plaster models of jaws were measured, including 64 models with retained primary molars and 62 models with premolars. The difference between the average sizes of the crowns of the teeth established by the literature data and by our own research is minimal. For the first time sum limits of the mesial/distal crown dimensions of the first and second primary molars were distinguished. This analysis reflects the macrodontia, the average size of teeth and microdontia. If the patient has the isolated macrodontia of primary mandibular molars and emerging distal occlusion of dentition the partial proximal removing of enamel (by grinding) from molars’ crowns is recommended. In the case of mesial occlusion of dentition it is recommended to proceed to the same procedure on the primary maxillary molars.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):132-138
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LABORATORY EVALUATION OF EFFICIENCY USE OF HERBAL REMEDIES IN THE TREATMENT OF HYPERTROPHIC GINGIVITIS
Biriukova U.A., Filimonova L.B., Galizina O.A.
Abstract
The article is devoted to studying of change of eytological indicators of gum’s mucous membrane in dabs prints before and after treatment of hypertrophic gingivitis, edematous form use herbal remedies and ortofen ointment.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):139-142
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WAYS OF EXPERIMENTAL MODELING OF VENOUS ENDOTHELIAL DYSFUNCTION: THE PRESENT STATE OF PROBLEM
Kalinin R.E., Suchkov I.A., Pshennikov A.S., Novikov A.N.
Abstract
Based on the literature data concerning modeling of venous diseases in experiments on animals the authors discuss various models of venous endothelial dysfunction. The models of venous thrombosis and L-NAME-induced endothelial dysfunction are considered to be the simplest and most readily reproducible.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):143-147
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AUTOAGGRESSIVE BEHAVIOR AND ALCOHOL ADDICTION AMONG PHYSICIANS (LITERATURE REVIEW)
Ozol S.N., Shustov D.I.
Abstract
On the basis of data, published in foreign and domestic literature, the analysis of problem of autoagressive behavior and alcohol addictions among physicians was performed. In addition, the question of professional deformation was considered.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):148-154
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OVERVIEW: FEATURES OF VERTEBROGENIC LUMBOSACRAL CHRONIC PAIN SYNDROME
Zhadnov V.A., Erkhova L.N.
Abstract
There are a biopsychosocial pain model, it consist of biological (anatomical, physiological), sociocultural (level of education, traditions) and psychological (cognitive, affective, behavioural) components. Also there are nociception (myofascial) and neuropathic (compression radiculopathy) components. The anatomical condition of the vertebral-motor segment often not correlated with the severity of pain syndrome. Assess the state of the peripheral segmental apparatus, peripheral nerves of the lower extremities, you can use stimulation ENMG.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):155-161
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ORGANIZATION OF MEDICAL ASSISTANCE TO THE WORKING POPULATION OF CLOSED ADMINISTRATIVE-TERRITORIAL EDUCATION
Fomin E.P.
Abstract
The health status of the population of closed administrative-territorial education (CATE) and its individual groups are investigated to a number of studies mainly aimed to identifying the effects of various professional factors on health. However, only a few works were carried out to improve the health care for CATE workers.
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):162-167
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KONOVALOV OLEG EVGEN'EVICh (k 55-letiyu so dnya rozhdeniya)
- -.
Abstract
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):168-169
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K SVEDENIYu AVTOROV
- -.
Abstract
I.P. Pavlov Russian Medical Biological Herald. 2014;22(3):171-174
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