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Vol 4, No 2 (2013)

Articles
Genetic and Epigenetic Aspects of Obessity and Metabolic Syndrom in Child
Tyrtova L.V., Parshina N.V., Skobeleva K.V.
Abstract
In a review article analyzes the role of heredity in the occurrence of obesity and metabolic syndrome. Debut of hyperphagia and severe obesity from early childhood are typical for monogenic forms and syndromes. Many nonspecific candidate-genes in combination form a polygenic basis for the accumulation of excess body fat, especially under the influence of irrational diet and low physical activity. Examined the role of epigenetic factors in the individual genetic variants in fetus, predisposing to obesity and metabolic syndrome after birth. Discuss the possibilities of early prevention of obesity and metabolic syndrome.
Pediatrician (St. Petersburg). 2013;4(2):3-11
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ANTIBIOTIC THERAPY IN CHILDREN WITH ACUTE TONSILITIS IN HOSPITAL INFECTION
Pavlova E.B., Timchenko V.N., Pavlova N.V., Sorokina I.Y.
Abstract
The results of clinical observation of children with lacunar tonsilitis treated with clarithromycin and cefazolin intramuscularly antibiotic therapy in an infectious diseases hospital. A comparable good clinical and microbiological efficacy of the two drugs was shown. However, clarithromycin demonstrated benefits. The results of clinical observation of children with lacunar tonsilitis treated with clarithromycin and cefazolin intramuscularly antibiotic therapy in an infectious diseases hospital. A comparable good clinical and microbiological efficacy of the two drugs was shown. However, clarithromycin demonstrated benefits.
Pediatrician (St. Petersburg). 2013;4(2):12-17
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THE FEATURES DEVELOPMENT AND CLINICAL COURSE OF PRIMARY CONGENITAL GLAUCOMA IN INFANTS
Zertsalova M.A., Brjeskiy V.V., Diskalenko O.V., Gaidar M.V.
Abstract
The development and clinical course of glaucoma in premature infants was studied. One hundred and one children with glaucoma in the age range from 1 month to 18 years were examined. Among all the examined patients, 69.3 % were born prematurely. Among the glaucoma patients, prevailed infants with a gestational period of 30–33 weeks, and body weight at birth 1050–1650 g. In all premature infants with glaucoma, retinopathy of prematurity was found, during the active phase of which, the patients predominantly received glucocorticoid drops, or the combination of drops with photocoagulation or cryotherapy. The onset of glaucoma in premature infants mostly occurs between 5 and 8 months post partum, i. e. the onset is later than in full term babies. This fact is to be taken into consideration in the follow-up care of such patients.
Pediatrician (St. Petersburg). 2013;4(2):18-23
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ENVIRONMENT AND HEALTH OF THE CHILDREN’S POPULATION
Keshishev I.A., Orel O.V., Smirnova V.I.
Abstract
The article presents some information on environmental conditions of a single of the largest in the North-West Federal District. Have learned the basic indicators of the health of children living in St. Petersburg, testifying of irregularities in the health of children. Negative tendencies in the dynamics of the basic of Medical and Biological health parameters studied group. In order to enhance the prevention occurrence of diseases are outlined organizational measures directed at strengthening the health of children living in the modern ecological situation of a large industrial center of the Russian Federation.
Pediatrician (St. Petersburg). 2013;4(2):24-27
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The state of the blood flow in patients with the adenomyosis
Arutyunyan A.F., Gaidukov S.N., Kostushov Y.V.
Abstract
The purpose of this study was to evaluate the specific features of uterine blood flow during adenomyosis to select appropriate treatment. 59 women were observed, among whom 49 suffered adenomyosis and 10 were healthy. Out of the 49 women in 34 was confirmed adenomyosis II–III degree of postoperative morphological studies, and in 15 patients — first degree adenomyosis after biopsy. In patients with first grade adenomyosis observed low-resistant uterine blood flow. However, in patients with adenomyosis II–III degree — high-resistant blood flow in uterine arteries and in vessels of the myometrium.
Pediatrician (St. Petersburg). 2013;4(2):28-31
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The comparative efficacy and tolerability of the latest fluoroquinolones in pediatric ophthalmology
Vorontsova T.N., Mikhailova M.V., Smoljaninova T.V., Brzheskiy V.V.
Abstract
The authors analyze the results of treatment of 45 children with bacterial conjunctivitis (87 eyes). All patients were divided into 3 groups: children of the first group received instillations of 0.3 % ofloxacin (Uniflox, Unimed Pharma), the second — 0.5 % levofloxacin (Oftaquix, Santen or Signizef, Promed Exports), the third — 0.3 % ciprofloxacin (Ciprolet, Dr Reddy`s Laboratories; Cilloxan, Alcon; Cipromed, Promed Exports). The patients received one of the above-mentioned fluoroquinolones 1 drop to each eye 5 times a day during 7 days. All patients were examined: plating of conjunctival cavity content, biomicroscopy of cornea and conjunctiva, staining of cornea and conjunctiva with fluorescein, measurement of tear film stability. All patients filled the questionnaire to estimate the tolerability of drugs. Results: eye drops containing 0.3 % ofloxacin, 0.5 % levofloxacin and 0.3 % ciprofloxacin showed equally high clinical effectiveness. The tolerability of ofloxacin and lexofloxacin drops was higher than ciprofloxacin according to subjective and objective (toxic effect to cornea) criteria.
Pediatrician (St. Petersburg). 2013;4(2):32-36
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System enzyme therapy for the children and teenagers
Sternin Y.I., Mikhailov I.B.
Abstract
One of the perspective treatment methods in pediatric practice is system enzyme therapy. The action mechanism of system enzyme therapy (Wobenzyme) was represented, such as inflations on the inflammatory process, immune system, vascular thrombocyte homeostasis. Separately examine the problems of Wobenzyme and antibiotic interaction, and also clinical researches of several diseases in pediatrics.
Pediatrician (St. Petersburg). 2013;4(2):37-44
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Peculiarities of the syndrome of ‘‘dry eye’’ in children with congenital glaucoma
Vorontsova O.A., Brzheskiy V.V.
Abstract
Authors analyze the results of examination of 33 children with congenital glaucoma in the age from 3 till 17 years old. Two groups were sorted out. Children of the first group were treated with 0.5 % timolol maleat, the minimal duration of treatment was 6 months (6 months–7 years). The second group included patients with congenital glaucoma without conservative treatment. The control group included 226 healthy children in the age from 3 till 17 years old without complaints and symptoms of dry eye. The decrease of tear break-up time was revealed in all children with congenital glaucoma. In patients receiving β-blocking treatment the decrease of basal tear secretion was also detected.
Pediatrician (St. Petersburg). 2013;4(2):45-51
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FEATURES OF DIAGNOSTICS AND TREATMENT OF CHRONIC INFECTIOUS-INFLAMMATORY DISEASES OF DIFFERENT LOCALIZATION
Fedorenko A.S., Burbello A.T., Gaikovaya L.B.
Abstract
In work the reasons of preservation of high frequency of recuring of chronic infectious-inflammatory diseases are analyzed. Possibilities of microbiological, immunological methods of research are estimated, on their basis approaches to selection of pharmacotherapy which will allow to reduce frequency of recuring of chronic infectious-inflammatory diseases at patients in ambulatory conditions are developed.
Pediatrician (St. Petersburg). 2013;4(2):52-56
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PATHOGENETIC MECHANISMS OF STRESS CARDIOMYOPATHY IN HIGH-QUALIFIED SPORTSMEN
Vasilenko V.S., Semenova Y.B.
Abstract
Hormonal and immune disturbances were investigated in high-qualified sportsmen during different periods of training cycle. Changed correlation of cortisol and testosterone levels was revealed. This fact is directly associated with significant immune dysfunction of Tand B-systems which leads to progression of cellular and humoral autoimmune reactions. These changes occure in the transitional period of the training cycle. It was confirmed that autoimmune reactions may be considered as the earliest markers of stress cardiomyopathy. Those sportsmen who develop these reactions must be classified as a risk-group.
Pediatrician (St. Petersburg). 2013;4(2):57-61
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Clinical management of the patients with optic disc pit
Zakirhodjaev R.A.
Abstract
The study purpose was to evaluate the effectiveness of the central serous choroidopathy prevention method in patients with optic nerve pit. Material and methods: 19 patients (38 eyes) with optic nerve pit associated with refractive anomalies and retinal dystrophy which had been treated in Republican Eye Hospital in 2010–2012. According to obtained results the effectiveness of prophylactic neuroprotective therapy in patients with optic disc pit has been proven, which allows reducing the risk of central serous choroidopathy and avoiding the loss of visual function.
Pediatrician (St. Petersburg). 2013;4(2):62-64
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LEVELS OF QUALITY OF LIFE OF MEDICAL STUDENTS WITH REGULAR AND IRREGULAR RECTAL RHYTHM
Shemerovskiy K.A., Ovsiannikov V.I., Nguyen H.C., Seniv O.I., Uspenskaya J.K., Mitreykin V.F.
Abstract
The levels of quality of life and the regularity of rectal rhythm was investigated in three groups of students: paediatricians, hygienists and general practitioners (GP). It was shown that students-paediatricians with regular rectal rhythm (RRR) have dominated the optimal level of quality of life (80 %–100 % from the maximum possible), while their colleagues with an irregular rectal rhythm (IRR) have dominated the moderate level of quality of life (40 %–60 %). Among students-hygienists with the RRR anxiety and insomnia were 2–3 times more rare than among their colleagues with IRR. Quality of life in students-GP with the RRR (according to the parameters of physical activity, daily activities and absence of pain) was significantly higher (74 %) than in their colleagues with IRR (65 %). RRR is the factor for a high level of quality of life, but IRR is associated with decreased levels of the quality of life of medical students.
Pediatrician (St. Petersburg). 2013;4(2):65-69
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Clinical features and rehabilitation of children with protein-energy malnutrition from socially disadvantaged families
Sokolova M.I., Akimov A.A., Shishkina Y.A., Novozhilova M.V., Alekhina G.G.
Abstract
Conducted research to identify the frequency and the main causes of protein-energy malnutrition in children without parental care. Investigated the state of the vital systems (nervous, cardiovascular, digestive). Presented the efficiency of rehabilitation of children with malnutrition using probiotic Laminolakt “Chernichka”, confirmed the safety of its use.
Pediatrician (St. Petersburg). 2013;4(2):70-74
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Personalized therapy with use of screening drugs in pediatrics
Volchek I.V., Petrov A.S., Osmalovskaya E.A.
Abstract
Currently, personalized medicine is one of the most promising areas of medicine XXI century. We review the data on the use of screening drugs in vitro by its effect on the thiol-disulfide ratio (TDR) of blood for the personalized treatment of chronic hepatitis C, herpes and human papillomavirus infection, chronic bronchitis, repeated giardiasis in children and adults, as well as personalized immunotherapy of frequently ill children. It is concluded that this method can be used to personalize the antibacterial, antiviral, antiprotozoal and immunotherapy in children in order to increase its efficiency, to overcome resistance to antibiotic, antiviral, antiprotozoal and immune drugs, search for the best medications, their dosages and combinations, reducing the incidence of side effects and cost of treatment.
Pediatrician (St. Petersburg). 2013;4(2):75-80
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Clinical difficulties of diagnostics of a syndrome of Prader–Willi
Guzeva V.I., Bessonova L.B., Seel K.A.
Abstract
Prader–Willi’s syndrome is a genetic anomaly which often masks under cerebral spastic infantile paralysis and myopathy diagnoses. Though at careful collecting the anamnesis, attentive survey of the patient and competent genetic inspection the diagnosis usually doesn’t raise doubts.
Pediatrician (St. Petersburg). 2013;4(2):81-84
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THE 30th ANNIVERSARY OF CLINICAL PHARMACOLOGY DEPARTMENT OF SPBSPMU
Mikhailov I.B.
Abstract
The editorial commemorating St. Petersburg State Pediatric Medical Universaty Clinical Pharmacology Department 30th anniversaty portrays basic historical stages of its development as well as achievements and contributions by the Depatment leading scientists into Clinical Pharmacology.
Pediatrician (St. Petersburg). 2013;4(2):85-88
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FEATURES OF DIAGNOSTICS AND TREATMENT OF CHRONIC INFECTIOUS-INFLAMMATORY DISEASES OF DIFFERENT LOCALIZATION
Grigoreva O.P., Savenkova N.D., Losovskaya M.E.
Abstract
In the article are presented peculiarities of the course of kidney disease in children infected with Mycobacterium tuberculosis. Discussed in detail issues of tubulointerstitial nephropathy, AA-amyloidosis, nephrotic syndrome in children with tuberculosis infection. Presents modern concepts on the mechanism of nephrotoxicity of different groups of anti-TB drugs.
Pediatrician (St. Petersburg). 2013;4(2):89-96
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Prolonged low-grade fever in children: modern aspects of diagnostic search
Khramtzova E.G., Muraveva N.N., Kliorina T.A., Akimov A.A.
Abstract
The lecture presents modern representations about etiopathogenesis and classification of the protracted subfebrile fever in children, the main features of the methodology of children examination are taken up. There are described the mechanisms of thermoregulation in early chidhood. The consecutive algorithm of diagnostic search is presented in order to determine the reasons of the protracted subfebrile fever. These reasons correlates with background microsemiology and age of the child. In the separate block there are presented the short description and methods of diagnostics of the endemic diseases. The separate block of the general anamnestic risk factors of the protracted subfebrile fever in childhood is allocated. In the separate block there are presented the short description and methods of diagnostics of the endemic diseases. Diagnostic search of the reasons of the protracted subfebrile fever in children surely should come to an end with the diagnosis, which is present in the international classification of diseases of the X revision.
Pediatrician (St. Petersburg). 2013;4(2):97-105
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Some problems of ultrasonography in the early diagnosis of the joints involvement in juvenile rheumatoid arthritis
Sulika Y.V., Akinshin I.I., Gorbunova T.O., Sinelnikova Y.V., Chasnyk V.G.
Abstract
The results of ultrasonography 557 joints of children with juvenile rheumatoid arthritis. This research showed that advantage of ultrasound is early detection of specific inflammatory markers of children with juvenile rheumatoid arthritis. The major ultrasound signs of joints damage are identified, depending on the duration of the disease.
Pediatrician (St. Petersburg). 2013;4(2):106-109
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