Clinical nutrition and metabolism

Peer-review quarterly medical journal.




  • Published under the supervision of National Association Organizations of Clinical Nutrition and Metabolism (RSPEN) 

Journal founders

  • Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology
  • Eco-Vector Publishing Group




The purpose of this peer-review academic medical journal is to publish up-to-date information on modern approaches to nutritional support for various conditions and diseases.

The target audience of the journal is specialists in the field of anesthesiology & resuscitation, pulmonology, surgery, oncology, neurology, gastroenterology, dietetics, pediatrics, therapy, as well as general practitioners.



Types of accepted articles

  • reviews
  • systematic reviews and metaanalyses
  • original research
  • clinical case reports and series
  • letters to the editor
  • short communications
  • clinial practice guidelines


  • in English and Russian
  • quarterly, 4 issues per year
  • continuously in Online First
  • with NO Article Processing Charges (APC)
  • distribution in Open Access, under the Creative Commons Attribution 4.0 International License (CC BY 4.0)


  • Russian Science Citation Index
  • Russian Science Electronic Library (
  • Google Scholar
  • Ulrich's Periodicals directory
  • Dimensions
  • Crossref


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Current Issue

Vol 4, No 2 (2023)

Original Study Articles

Nutritional assessment and nutritional status of centenarians (based on the materials of the study “Centenary citizen” in Moscow)
Gotina A.D., Ivannikova E.V., Eruslanova K.A., krylov K.Y., Kotovskaya Y.V., Tkacheva O.N.

BACKGROUND: Malnutrition and micro- and macronutrient deficiencies are common in people aged 95 years and older. For timely detection of nutritional disorders, it is crucial to regularly examine centenarians and, if necessary, correct an individual patient management plan. A well-balanced diet is one of the fundamental factors for the normal functioning of the human body throughout its life. With age, for various reasons, the risk of malnutrition increases, however, the nutritional status of centenarians is currently not fully understood due to the difficulties of diagnosis.

AIM: To evaluate nutritional status and its impact on life expectancy in patients aged 95 years and older, to identify the main determinants that affect the development of malnutrition, and to assess their impact on three-year survival of centenarians.

MATERIALS AND METHODS: Analyzed the results of a Mini Nutritional Assessment, general and biochemical blood tests (including such parameters as hemoglobin levels, iron levels, total protein, albumin, vitamin B12, vitamin D, folic acid) in non-institutionalized people aged 95 and older living in Moscow. All studies were conducted at home in the presence of relatives and/or social workers after signing a voluntary informed consent.

RESULTS: The study included 82 people, mean age (98.3±1.89) years; 87.8% were women. Of all the study participants, 56.1% (n=46) were at risk of developing malnutrition, and 11% (n=9) had malnutrition syndrome. Among the 64 participants who took the blood test, anemia was diagnosed in 71.9% (n=46), with macrocytic in 10.9% (n=5), normocytic in 84.8% (n=39), and microcytic in 4.3% (n=2) of patients. Hypoalbuminemia was identified in 16.9% (n=11 of 65) of participants. Of the 50 people who were screened for vitamin D levels, vitamin D deficiency was found in 98% (n=49 out of 50). The following factors influenced survival: a Mini Nutritional Assessment score of more than 24 reduces the risk of 3-year death by 72% (odds ratio (OR) — 0.28, confidence interval (CI) — 0.1–0.8), anemia increases the adverse risk by 3 times (OR=3.1, CI 1.1–8.9). The main clinical conditions associated with a higher risk of developing malnutrition were anemia (OR=3.1, CI 1.1–8.9) and chewing problems (OR=2.8, CI 0.9–7.8).

CONCLUSIONS: Conducting a nutrition assessment and drawing up a program for the prevention of malnutrition syndrome in centenarians will improve the quality of life and increase life expectancy.

Clinical nutrition and metabolism. 2023;4(2):54-65
pages 54-65 views
Evaluation of the frequency of consumption of various groups of dairy products by students of the Peoples’ Friendship University of Russia
Khanferyan R.A., Radysh I.V., Semin D.A., Geyko E.G., Korosteleva M.M.

BACKGROUND: Milk and dairy products are an important component of a balanced diet. Milk and dairy products deficiency contributes to the violation of the main health indicators of various age groups of the population.

AIM: The purpose of this study was to analyze the frequency of consumption of various groups of dairy products by students.

MATERIALS AND METHODS: 388 full-time students of the Medical Institute of the Peoples’ Friendship University of Russia took part in the cross-sectional study. Of all the participants, 185 were men and 203 were women; the average age was (20.4±2.2) and (21.9±1.7) years, respectively. Anthropometric measurements were performed according to the standard program. The frequency of consumption of various groups of dairy products was studied using a modified questionnaire on the frequency of consumption of products.

RESULTS: analysis of the questionnaire on the frequency of consumption of products demonstrated that approximately 14% of the respondents did not consume milk over the past month, about a third — cottage cheese, 21% — natural sour-milk products and 16% — sour-milk products with various fillers. Hard cheeses and pickled cheeses are absent from daily food rations of 7% and 20% of respondents, respectively. Daily consumption was recorded as follows: milk — 24% of respondents; cottage cheese — 5%; fermented milk products (natural and with flavored) — 9% and 8%, respectively; hard cheese — 18%. The study also revealed gender differences in the characteristics of consumer preferences: women are less likely to consume cream, sour cream, soft cheese and milk. Among female students, the prevalence of overweight individuals was higher and amounted to 25% (n=50), while among male students — 19% (n=35). A modest inverse relationship was found between daily milk intake and body weight, as well as between milk intake and body mass index (r=–0.61 and r=–0.65, respectively).

CONCLUSIONS: our study revealed insufficient consumption of milk and dairy products among students. The relationship between the frequency of their consumption and indicators of physical development was noted.

Clinical nutrition and metabolism. 2023;4(2):66-74
pages 66-74 views


Anti-RAGE targets in cachexia: HMGB1, S100B, S100A1
Obukhova O.A., Mikhailova I.N., Treshalina H.M., Manina I.V., Markina I.G., Zukov R.A.

Cachexia, mediated by the multiligand receptor RAGE (receptor for advanced glycation end products) and its ligands HMGB1, S100B, and S100A1, is a formidable multifactorial complication of the severe course of a number of somatic and malignant diseases. One of the most visualized symptoms of cachexia is a significant decrease in body weight, but the main one is the systemic shutdown of a number of regulatory centers that control the maintenance of homeostasis. Activation of these markers contributes to the launch and intensification of the destructive processes of cachexia, and blocking, in some cases, can reduce their intensity. Among known drugs from various therapeutic groups, there are blockers of one or more markers. For example, Papaverine antispasmodic as well as the nootropic anxiolytic Tenoten, antibacterial Pentamidine and antidepressant Duloxetine. This review describes in detail the significance of the listed markers in the pathogenesis of cachexia, especially in malignant pathology. An assumption was made about the possible control of cachectic progression with the help of such blockers to improve the quality of life of patients.

Clinical nutrition and metabolism. 2023;4(2):75-82
pages 75-82 views
Modern aspects of infusion therapy: review
Khalikova E.Y., Zolotova E.N., Shtanev Z.D.

The infusion therapy is a routine procedure of the nowadays perioperative period and critical patient treatment. But there are controversial questions about the quantity, quality, start and duration of infusion therapy, which are under discussion. Modern infusion therapy includes intravenous administration of crystalloid solutions and more rarely colloid solutions. The type, amount and rate of infusion fluid depends on the indication for infusion therapy and the specific requirements of the patient. Nowadays colloidal solutions have limited indications. Crystalloid solutions are used for infusion therapy of patients with hypovolemia or dehydration, correction of free water deficiency, correction of electrolyte disorders, replenishment of ongoing fluid losses and replacement for patients who unable to drink water orally. All patients should be monitored with combination of clinical parameters and laboratory tests. Therapeutic endpoints should be determined. The moment these endpoints are achieved fluid therapy should be appropriately de-escalated in order to avoid overhydration.

Clinical nutrition and metabolism. 2023;4(2):83-98
pages 83-98 views

Case reports

Nutritional support in the complex therapy of clostridial infection after surgery
Kuzmina T.N., Smirnova O.A., Sergeeva A.V., Baychorov A.B.

This article presents the tactics of nutritional support in a patient with pseudomembranous colitis after repeated consecutive operations on the abdominal organs, which led to significant violations of the nutritional status. Competent, individually selected correction of protein-energy deficiency in patients with pseudomembranous colitis allows achieving an effective treatment result, avoiding severe complications such as perforation, toxic dilatation, and bleeding. The peculiarity of this clinical case is that a patient with perforation of Meckel’s diverticulum and abdominal abscess developed a complication — secondary widespread peritonitis, phlegmon, which required repeated surgical interventions. Surgical treatment and massive antibiotic therapy led to the development of Clostridium difficile infection: during the treatment the patient developed multiple loose stools and C. difficile toxins A and B were detected. Severe pseudomembranous colitis was accompanied by protein-energy deficiency (hypoproteinemia, hypoalbuminemia), severe dehydration, hypokalemia, hyponatremia, and moderately severe anemia of complex genesis. When selecting nutritional support for patients with clostridial infection, it is important to take into account severe systemic inflammation, which affects the absorption and absorption of the intestinal wall, which in turn determines the route of introduction of nutrient substrates. In this case we needed to choose the right method for correcting the patient’s nutritional status.

Clinical nutrition and metabolism. 2023;4(2):99-106
pages 99-106 views

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