Vol 12, No 1 (2012)

Peculiarities of neurological manifestations of absence epilepsy and supported mechanisms of onset, development and termination of absence seizures are described. Clinical observations in patients with absence seizures and experimental data on genetic animal models are considered and the evidences point out the leading part of thalamocortical system in initiation and maintenance of seizure activity. A comparison of antiepileptic drugs using treatment of absence epilepsy is present.

The present study is dedicated to the characterization of the cell population obtained from the normal human endometrium. The conditions of selection, cultivation, cryopreservation and the phenotype of the cultured endometrial cells are described. Receptors of estrogen and progesterone as immunohistochemical markers of the endometrium are revealed. Data of precise immunophenotyping and caryotyping of the isolated human endometrium cells are presented.

Electroencephalograms (EEG) and case reports of 145 patients suffering posttraumatic encephalopathy have been subjected to analysis. The patients were divided into two groups: a group of patients in prolonged unconscious state (1 st, n=20) and a group of conscious patients with late effects of severe craniocerebral trauma (2 nd, n=125). Background EEG has been subjected to analysis by application of independent component analysis (ICA) and standard low-resolution electromagnetic tomography. According to maximum equivalent current density localization, the EEG independent components have been identified in frontal, temporal and occipital lobes. Both integral index (λ+θ/α+β1+β2) of EEG independent components power-spectra and effect size have been calculated for each EEG independent component localization. The average effect size of power-spectra integral index (λ+θ/α+β1+β2) has been identified for all EEG independent component localizations subjected to examination. A correlation analysis between absolute and relative index values (λ+θ/α+β1+β2) of EEG independent components power-spectra in frontal and occipital localizations and severe craniocerebral trauma outcomes ranged by Glasgow Outcome Scale has been applied to the group of patients in prolonged unconscious state, who have been followed-up (under surveillance) for a period of 6 to 18 months (1A, n=10). The results in group 1A have shown that relative values of EEG independent components power-spectra in frontal and occipital localizations are in inverse reliable correlation with severe craniocerebral trauma outcomes ranged by Glasgow Outcome Scale.

The purpose of the study was to identify and determine the immune reactivity of sub-cellular fractions of sreroidogenic cells and to measure quantitatively the organ specific autoantibodies. The high immunogenicity of microsomal fractions of human adrenal and gonad steroid-producing cells was shown as a result of investigation. The border levels for natural organ specific autoantibodies out of pathologies were established. In laboratory materials, the statistically significant increase of plasma antibodies to adrenocortical, ovarian and testicular antigens in immune mediated destruction of adrenals and gonads in humans was shown. The results are in good accordance with data of high immune reactivity of steroid genesis hydrolase enzymes. Their pathogenic role is more significant than the same of steroid hormones in states of immune pathology of the adrenal glands and gonads.

One of the central effects of selective agonist of V2 receptors of vasopressin, 1-desamino-8-D-arginine vasopressin (DDAVP), was studied in treatment of patients in residual stage of stroke. In patients in mature age and elderly neuropeptide increased the average linear velocity of blood flow in the middle cerebral artery, in basin of which has developed of a stroke. We revealed a normalized effect of vasopressin on cerebral circulation in post-stroke patients in combination with decreased neuropsychiatric disorders. These findings point to new features of vasopressin, enhance understanding of its functional role in humans and possible uses of the neuropeptide in neurological patients.

The present study was performed on 48 adult subjects (18 women and 30 men aged 18 to 67 years) with various disorders of behavior and psycho-emotional state. Based on these results was developed a phased methodology for the application of motivation auditory training with external video feedback on the galvanic skin response, heart rate, electromyogram, and photoplethysmogram for adaptive self-regulation and correction of human functional state.