Vol 24, No 10 (2013)

The paper analyzes the current concepts of the pathogenesis of osteoarthrosis (OA) and the role of metabolic disturbances in injury to joint structures. It discusses possible ways to enhance the efficiency of OA pharmacotherapy.

The paper discusses the epidemiology, etiology, pathogenesis, and pharmacotherapy of noninfectious diarrhea. It gives clinical and epidemiological data on the efficiency and safety of drugs from different groups to treat diarrhea of varying genesis.

The investigation showed that the N34S mutation in the SPINK1 gene (a pancreatic secretory trypsin inhibitor gene) was most common in patients with toxic and idiopathic chronic pancreatitis (CP). The significantly high rate of identification of the above mutation in patients with complicated forms of idiopathic CP suggests the increased risk of disease complications.

An experiment ascertained the positive effect of Panagin on cardiac resistance to fibrillation and hypocoagulative changes in rats with myocardial hypertrophy under low- and highland conditions with a more pronounced effect in the mountains (3200 m above sea level).

The paper considers the tactics of pain syndrome relief in patients with large joint osteoarthrosis. Major attention is given to therapy with nonsteroidal antiinflammatory drugs.

The sequel of brain injury (BI) may be hypopituitarism, the development of which potentially worsens rehabilitation and prognosis. Cohort studies have shown that the rate of posttraumatic hypopituitarism is 15 to 90%. According to the data obtained by a number of authors, secondary hypocorticism is one of the most common types of tropic insufficiency in posttraumatic hypopituitarism. The authors describe their clinical case of isolated secondary hypocorticism developing after BI.

The article is devoted to the study of male adolescent health in cases with different intensity of physical activity: persons with low, intermediate level and professional athletes as well as prevalent consumption of psychoactive substances (PAS) in the studied groups.

Examination of 58 patients with HBeAg-negative chronic hepatitis B (CHB) with HBsAg +- and HBsAg - phenotypes of hepatitis B virus infection revealed a considerable predominance of small liver cell dysplasia over large liver cell one, an upward trend for liver cell dysplasia in HBsAg loss, and a direct correlation of hepatocyte dysplasia with the magnitude of a necrotic/inflammatory process and the hepatocyte levels of HBcorAg in HBsAg -.

The Sandra Bam index was used to assess the gender type of behavior in 70 patients with panic disorder (PD) and in 50 healthy individuals. The masculine type was found in 4.3% of the patients versus 22% of the healthy population (p = 0.002). The dominant gender types were androgynous and masculine in the healthy men; on the contrary, feminine gender role behavior is most common in the men with PD. Gender behavior in the men was associated with the type of PD. PD with agoraphobia is characteristic of the men with feminine gender behavior and that without agoraphobia was more common in the men with androgynous gender behavior, in whom alcoholic excesses were a characteristic trigger of the first attacks. Inadequate masculinization is a characteristic personality trait in the patients with PD and a predisposing factor in the formation of avoidance behavior.

A 5-year prospective cohort study was conducted in patients (mean age 69.0±5.9 years) with gastroesophageal reflux disease. The results of discriminant analysis were used to derive original formulas that are supported by a Russian Federation patent for invention and can predict the unfavorable course of the disease in elderly patients to an accuracy of 97.1%.

Subclinical hypercorticism (SH) is characterized by impaired cortisol secretion without specific clinical manifestations of hypercorticism. According to various sources, the prevalence of SH varies between 5-30% among patients with adrenal masses. Sixty-four patients with adrenal incidentalomas were examined; 11 of them were found to have SH. Surgery was performed in 1 patient. Based on the findings, the authors propose an algorithm for examination of patients with adrenal incidentalomas for SH.