Vol 14, No 2 (2015)

The assessment of dynamics of facial soft tissues thickness (58 cases) and morphological researches of a fatty autograft before and after a fat grafting (13 cases) at patients with the congenital and acquired contour facial deformations for the purpose of postoperative result forecasting and determination of recovery treatment terms were carried out. Direct dependence of "the additional thickness" retension and recipient zone thickness is established, so in 3-4 months in cheek area 60-65% of "the additional thickness " remain, and in malar area of only 25-27%, further the given indicators remain stable. There is a changing of tissue thickness during 3-4 months, so after that term postoperative results estimation and making the decision about recurrent operation is possible. According to the morphological researches, the additional thickness of tissues consists of: adipocytes, adipocytes in a condition of a nerobiosis, and also vascularized cicatricial connecting tissue. Because of that recipient area after a fat grafting can be palpatory more dense or have rough contours. Therefore at "plus tissue" postoperative deformations all physiotherapeutic methods (in the individual mode) which are applied to treatment of pathological scars are effective.

The aim of the work was to study the effect of the device features «PlasmaJet» on the face with the age-related changes of the skin and Acnae vulgaris. The study involved 20 people. The first group consisted of 10 patients with age-related changes of the skin. For this group of patients on the unit «PlasmaJet» was held for 5 sessions of combined exposure mode Pulse Mode, lasting 30 minutes, with an interval of 1 week. To assess the effectiveness of the procedures carried out photo-, the study of functional parameters of facial skin (profilers kutometriya, corneometer, ultrasound - scan), histological and immunohistochemical study of skin samples before and after all procedures. The second group consisted of 10 patients with inflammatory diseases of the skin (acne), which was held on 3 treatments combined effects mode Pulse Mode, lasting 30 minutes. The intervals between treatments is 3-4 days. To assess the effectiveness of the procedures carried out photo-, the study of functional parameters of facial skin (pigmentometriya, sebumetriya) before and after all procedures specified test program. The results of comparative evaluation of the effectiveness of the impact of treatments on the skin using the apparatus «PlasmaJet» Mode Pulse Mode showed that in patients with age-related skin changes was an increase in indicators of moisture, elasticity, as well as reducing the size of wrinkles. Patients with inflammatory diseases of the skin (acne) showed normalization of the activity of the sebaceous glands of the face, reduction in the intensity of erythema and manifestations of inflammatory diseases of the skin, improvement in overall appearance. Immunohistochemical studies revealed a stimulating effect on the skin cells of patients, improving the ability of synthetic leather and activation systems to combat damaged skin cells. Thus, the use of apparatus «PlasmaJet» can be recommended for patients with age-related changes of the skin to increase its turgor, increased humidity and leveling micro-relief to rejuvenate the skin, as well as for the treatment of patients with inflammatory diseases of the skin (acne).

Skin diagnosis is important for the ermatology and cosmetology practice. The aim of this study was to evaluate the ultrasound characteristics and quantitative determination of dimensions, boundaries, and acoustic density of skin tumors. Under our supervision there were 32 patients with benign and malignant skin tumors. High-frequency ultrasound 22 MHz and 75 MHz with a resolution of 72 and 21 μιτι was used in this study. We determined the size, depth distribution, and acoustic density of the tumor at all patient. All tumors were hypoechoic compared with the surrounding tissues. In most cases, with high probability were able to determine the source of primary tumor growth, thanks to the high resolution ultrasonography. For the first time in Russia used a combination of videodermatoscopy and high-frequency sonography in monitoring the skin of patients with basal cell carcinoma. High-frequency ultrasound study with high precision allows to determine the size and depth and boarders of the tumors, which is important for the treatment choice, and evaluation of treatment results, and also to prevent a recurrence of tumors.

It was followed by an open non-randomized clinical trial of the safety and efficacy as an anti-aging drug biologically active food supplement «Selerdzhen» in a group of clinically healthy volunteers of both sexes (age variation in a group of 41 people was 33-72 years). As a secondary performance indicator, measured biochemical parameters of the redox status and collagen production. The protocol of the clinical trial was approved by the Ethics Committee of the Institute and all study participants gave written informed consent. Participants were recruited on the basis of the criteria included in the test and exclude from the trial. They were asked to take 2 capsules of the drug «Selerdzhen» a day for two months. During the test period, all participants did not have to take any other dietary supplements or vitamins. Admission BAA objectively assess the level of coenzyme Ku10 levels as «Selerdzhen» contains the active ingredient as a coenzyme. Safety of the drug was evaluated subjectively, taking into account the opinion of the attending physician and member of the test. Clinical (aesthetic anti-aging effect) was evaluated by digital photographs taken at the beginning and end of the test, as well as questionnaires completed by the physician and the patient. Instrumental methods for assessing anti-aging effect on the skin include functional parameters of physiology of the skin, such as elasticity, greasiness and moisturized. It was held a specialized ultrasound analysis of skin layers, which are determined by the thickness and order of collagen fibers in the epidermis and dermis. Based on the results estimated biological age of skin before and after the study. Laboratory biochemical analyzes included: determining the level of hydroxyproline levels as a measure of collagen synthesis; nitrite and nitrate in plasma; activity of the main antioxidant enzymes such as superoxide dismutase, glutathione peroxidase and glutathione-S-transferase; the level of reduced glutathione in red blood cells; the content of malondialdehyde in plasma; urovet ATP in erythrocytes. All data were statistically analyzed using a suitable method of analysis. Results of statistical treatment showed that «Selerdzhen» has a certain anti-aging effect on the skin, reducing its biological age, has energizing effect, increasing the ATP stores, changing the redox potential by shifting it to the side corresponding to a younger age.

Complex treatment with application of the extracorporal shock wave therapy (ESWT) of 58 patients with a vibration illness from various degree of expressiveness is carried out. The comparative group was made by the persons which are on medicinal therapy without use of ESWT. The main clinical manifestation of an illness was the pain syndrome of the top extremities of moderate degree of expressiveness against a vegeto-touch polyneuropathy. The assessment of results of treatment revealed earlier and permanent regress of pains in comparison with traditional treatment. Regress of pain syndrome is connected with the normalizing influence of ESWT on a condition of peroxide oxidation of lipids and level of pro-inflammatory суtokine, in particular, a tumor necrosis factor α.

The consequences of hysterectomy for a woman - one of the most discussed problems of modern gynecology. The aim of our study was to identify differences in the general health and feeding behavior of patients with severe manifestation or progression of obesity without such after undergoing a hysterectomy with preservation of ovaries. The study included 34 women 5 years after a hysterectomy without appendages or fallopian tubes. At the time of the study age was 46,4 ± 3,2 years. The study group included 22 women who reported an increase in the period of time after the surgery the body weight of 10-25 kg (14 ± 3,2). The control group consisted of 12 women whose weight for the period was stable or increased by no more than 3 kg. The study included a survey, the general clinical examination, testing the questionnaire assessment of eating behavior (Dutch eating behavior questionnaire (DEBQ) 1986). Also perform electroencephalography. Symptoms that are highly likely to indicate a hypothalamic dysfunction (stretch marks on the skin during puberty, periods of neurogenic hyperthermia, hyperhidrosis, headaches, primary giperdipsiya, various sleep disorders, autonomic crises, mood disorders, severe heat intolerance and meteozavisimost) 1-3 symptoms observed in all of the main group, while in the control group - only two women. In the study group 31,8% of the surveyed believed that ever in my life have been different duration periods of mental depression in the control group of women was not. On a scale of externalities eating behavior index of the main group was 3,5 ± 1,4, the control 1,4 ± 0,5 (the statutory rate -no higher than 2,68). On a scale of emotion-eating behavior, the rate at which normally should not be higher than 2,03, it was 4,03 ± 1,6 in the main group and 2,9 ± 0,7 - in control. When the EEG in the study group, 16 women (72%) had moderate or severe disorganization of background activity. In the control group, the changes in the EEG, lets talk about the probable dysfunction diencephalic brain structures observed in all 3 people. Based on the data, it can be assumed that the performance of a hysterectomy is not so much the cause as a trigger the development or progression of obesity in the presence of prerequisites (dysfunction diencephalic brain structures), eating disorders, addiction to depression).

Inflammation, as a universal biological and pathological process accompanies almost all skin diseases, and is part of the reparative processes in the skin. Determining the intensity of inflammation and precise localization of inflammatory lesions is important for diagnosis and treatment. The aim of the study was to describe the ultrasound signs of inflammation in the skin and quantification of the size and borders of inflammatory lesions in the skin using high frequency ultrasonography. Under our supervision there were 46 patients with infiltrative inflammatory changes in the skin of various etiologies in age from 14 to 65 years. We imagingused high-frequency ultrasound imaging at a frequency of 22 and 75 MHz with a resolution of 72 and 21 μm. Determined the location, size and extent of the inflammation within intact tissues. Measured acoustic density inflamed and unmodified fabrics. High frequency ultrasound can be used as a quantitative method of monitoring inflammatory lesions for diagnosis and evaluation of treatment effectiveness.