Vol 17, No 1 (2018)

The multifactorial nature of health and the need for deep personalization of health-saving programs necessitates the use of modern information and cognitive technologies for assessment and management of health. The paper presents the concept, basic methods and structure of intelligent Internet technologies for personalized support of health-saving, as well as an example of practical implementation of such technology.

The international data on influence of placentary therapy on recovery processes are provided in a human body in this article. Mechanisms of regeneration of bodies and fabrics, and also recovery processes of metabolism of a human body on the basis of the 80th summer experience of use of placentary medicines and in particular a hydrolyzate of a placenta of the person Layennek (Japan Bioproducts Industry, Japan) are stated. From the point of view of evidential medicine the multifunctional pharmacological properties of placentary medicines which are defined by their multicomponent and native structure reveal.

It is well known that mitochondrial dysfunction is directly related to many age-depending noninfectious chronic diseases accompanied by the critical reductions in the aerobic synthesis of ATP. The ability of mitochondria to comply with the environmental conditions and proper mitochondrial functioning occur only in the presence of adequate partial pressure of oxygen in the inner mitochondrial membranes, which results in the most effective energy production while meeting the cellular needs in energy. The reduced protons and free electrons accepted in the oxygen molecules are end products of aerobic metabolism in healthy mitochondria, leading to production of ATP and formation of such physiological metabolites as water and carbon dioxide. The increasing subclinical cellular hypoxia caused by interdependent complex factors - dietary intake of energy metabolites and tissue oxygenation - contributes to oxidative stress, which is commonly accepted as one of the main causes of age-dependent noninfectious chronic diseases.

The study was undertaken to assess the opportunities of use of the indicators of mental efficiency, sensorimotor coordination and psycho-emotional state as markers of bioage. Analysis of age-related trends is made on the basis of experimental data obtained by computer system “SOPR-monitoring” in three experiments - a longitudinal one, a crosssectional one and a mixed one. Age-related decline in the counting productivity, reaction to the moving object, somatic state, tone and mood was detected at both individual and group level. It is shown that indicators of performance depend heavily on individual abilities to certain activities and on professional experience. Taking into account individual trends of those indicators can significantly improve the accuracy of bioage estimation, however, it requires a sufficiently long monitoring.

The article deals with peculiarities of application of non-medicamental methods of therapy of drug-dependent persons in post-abstinent stage of rehabilitation. Based on the study and analysis of the literature is psychological mapping of such therapeutic techniques as electrophoresis, electrosleep, oxygen therapy, biofeedback therapy, DENAS - therapy. Discusses their empirical capacity to address the therapeutic targets of non-medical workers in a rehabilitation centre for drug addicts.

The increasing of the population life expectancy is the demographic situation world trend in the industrially developed countries. International scientific, medical-social, infrastructural and educational projects are being created in response to the modern challenges. The new Master’s program in the field of training 32.04.01 "Public Health", the profile "Personalized health management and active ageing" is developing for solving socially significant problems to increase the quality of life and longevity of the Russian population. The Master’s program takes into account the main requirements of the National Technological Initiative-2035 HealthNet and compliances to the federal state educational standards approved by the Order of the Ministry of Education and Science of the Russian Federation.

The purpose of our study was to evaluate the impact of ozonotherapy on the results of cell therapy of experimental liver cirrhosis. White Wistar male rats (n=45) were used as an object of our study. After modeling of liver cirrhosis a course of ozonotherapy for one group of rats (group 3) was performed. Than animals of groups 2 and 3 were treated with single intra-portal injection of autologous mesenchymal stem cells (MSCs). Animals had been sacrificed before cell therapy, 30 days and 90 days after cell transplantation, pathohistological state of liver, prooxidant and antioxidant markers of blood serum had been examined with further statistical analysis. Administration of autologous MSCs in experimental liver cirrhosis leads to statistically significant consistent reduction of thickness of connective-tissue septa in liver (р=0,0041), decreasing of prooxidant markers concentration and increasing of antioxidant markers activity (p=0,009) 30 days and 90 days after cell transplantation in comparison with control animals. Course of ozonotherapy before cell therapy leads to statistically significant improvement of mentioned indicators in comparison to those in case of monotherapy with stem cells (р<0,05). Transplantation of autologous MSCs leads to consistent improvement of histological state in liver cirrhosis 30 days and 90 days after cell therapy. Ozonotherapy facilitates the improvement of the results of cell therapy of experimental liver cirrhosis. The mechanism of the positive impact of ozonotherapy is probably in its antioxidant effect, which occur in statistically significant decreasing of prooxidant markers concentration and increasing of antioxidant markers activity.

The article presents the results of the study of the dynamics of the functional state of the pupils of the Youth Sports School during the period of competitive activity. After a full survey of athletes with the definition of physical development and comparison of the obtained indicators with the average indicators, the period of intensive training and competitive activity followed. The study involved 300 young athletes - students of the Youth Sports School, 150 of which - boys 11 years old, and 150 -12 years. The received results testify that all sportsmen at the time of the beginning of the research have good physical data and a high adaptation to physical loads. Boys of both age groups recover quickly after training, shifts of hemodynamics and biochemical blood parameters at the same time correspond to the loads and quickly return to the initial ones without harmful influence on the state of organs and systems. In the study of the nervous system, it was found that in the development of static and motor functions, conditioned reflex activity and language, children of both age groups did not lag behind their peers (from a pediatric history). The results of the survey after the competitive period indicate a significant decrease in endurance and resistance to hypoxia of young athletes of both groups. Despite the fact that the indicators of physical development of athletes have remained the same, the endurance rates have significantly decreased, ке. there was a discreption of these indicators. After the competitive period, the hemodynamic parameters of all subjects significantly worsened, and the increase in the concentration of lactic acid in the blood suggests that the organisms of athletes do not have time to recover after intensive physical exertion, and this does not lead to training and adaptation, but, on the contrary, worsens the general condition of the young athletes and reduces its ability to achieve professional success. Thus, comparing the data at the time of the beginning of the study and after six months of intensive training and the competition period, the necessity of developing a complex of restorative measures with the purpose of blocking the development of the overtraining syndrome among young athletes was confirmed.