Vol 5, No 4 (2005)

The HIV-infection epidemic spreading in Russia also affects those in military service, compromising the state's defence power. A system of HIV-infection prevention has been developed by the medical service of the Armed Forces, and is functioning successfully. Military groups are a unique model for conducting scientific research, as well as for carrying out prophylactic programs. A closer interaction of civil and military scientists is one of the ways to improve the effectiveness of HIV-infection epidemic prevention.

The data on the influence on lung cancer (LC) predisposition of so-called «unfavourable» alleles of polymorphic genes, which products take part in tobacco smoke carcinogens metabolism are provided in this article. We showed that the mutant allele with T6235C substitution in CYP1A1 gene, which codes arylhydrocar-bonhydroxylase (АНН), is associated with lung cancer susceptibility, especially with squamose cancer (SCLC). Also the obtained date on the prevalence of GSTM1 gene deletions in patients with LC allows the above-mentioned polymorphism on the LC risk. The evidence of the increased LC risk in the carriers of the mutant alleles in both genes are provided.

According to the published data, the frequency of the combination of adenomyosis (AM) and leiomyoma (LM) of the uterus is 50-85% of cases of AM. Recognition of such a combination makes a complex problem to the clinician and linked with large diversity of features of these diseases with the absence of typical symptoms, and various forms of changes.

We performed a detailed comparative clinical and morphological analysis of 50 cases of AM and 150 cases of AM/LM combination. This analysis revealed the considerable hypodiagnostics of AM, especially by its combination with LM and/or by the presence of perifocal leiomyomatous hyperplasia. The regularity of perifocal leiomyomatous hyperplasia with microscopic forms of LM and/or the diffusive thickening of myometrium has lead to the increase of uterus size in AM. The immunohistochemical investigation revealed the correlation of expression of the estrogen and progesterone receptors in glandular epithelium and stromal cells of the AM foci, and in the leiomyocytes in perifocal hyperplasia areas of myometrium. This indicated the uniformity of the pathogenetic mechanisms of AM and LM. Differences in the symptomatology and clinical course of AM and of AM/LM combination were also established in our work. The diagnosis of AM demands the comprehensive investigation of patients taking into consideration the frequency of the combined forms and distinct features of their clinical and morphological parameters.

The mathematical model of development of an erythropoiesis in erythroblastic islands culture has been built for the first time. At realization of experiments on cultivation of erythroblastic islands the sequential analysis of Wald has been applied. At constant values of parameters of cultivation regression model allows to reveal frame of connection of a erythropoitin dose, duration of cultivation and an amount of erythroblastic islands in culture, and also to predict productivity of erythroblastic islands culture depending on preset values (a dose of erythropoietin and duration of cultivation).

In the sharp period of posttraumatic disease (period of shock) systemic hypoperfusion caused to ishemia and damage of target-organs (organs with high level of methabolism): intestinum, marrow, hepar, kidneys.

In the early period of posttraumatic disease reperfusion damages of this organs is manifest syndrome of systemic inflammatory response (SIRS). Damages of mucous tissue on intestinum lead to translocation endogeneous bacteria in blood.

The feature of late period of posttraumatic disease is the presence of dead tissues, bacteremia and depression of immune defense. All this create the conditions on transformation aseptic SIRS to sepsis

By the purpose of work was the retrospective comparative research of a condition immune system at two groups of the patients (having complication of treatment and without those) with seasonal allergic rhinit prior to the beginning treatment and at early stages of realization allergovaccination. 125 patients with sensibilisation to pollen of weed grass were surveyed. The patients complications immunotherapy more often have not allergic chronic diseases. Before initiation allergovaccination the level IgM is higher and less quantity common IgE. Allergovaccination is accompanied by earlier change of mechanisms regulation of levels common IgE and deferred reactions cells and phagocytic of parts immune system. On the basis of given anamnes, change of a ratio CD4/CD8, quantity CD19, phagocytosys of a parameter and levels IgE, IgM per the first month of realization allergovaccination forecasting risk of occurrence of system complications is possible.

It was investigated expression of melatonin in placentas in comparison with them morphological condition in mothers, who born newborns with intrauterine growth retardation. Our data showed that high melatonin expression was identified only in placentas with the subcompensated placental insufficiency. Melatonin expression increased in cases when the adaptation mechanism exhausted.

The researches were carried out with medical staff (volunteers) of a first aid station in St. Petersburg. A mobilizing method of cardiorhythm functional control with visual biofeedback was used for normalizing of human state and decreasing of stress-induced influences. The examinations were carried out at the first hours of 24 hours' watch. The checkup session for the comparative analysis of the volunteers’ state fulfilled after watching. The every participating in cardiotraining procedures marked some improvement of own general state, mood and increment of capacity for work. The arterial pressure and the heart rate normalized with the biofeedback control procedures. The anxiety reduced, the perception of individual time has come nearer to metric estimation. The mobilization version of the oscillatory cardio-dependent biofeedback technology can be applied for adaptive correction and improvement of operator’s condition.