Vol 48, No 1 (1999)

The forming specifies of Postovarioectomic syndrome (POES) after extirpation of uterine with both adnex in transitive age (after 45 years) in regular menstrual cycle was investigated. The high frequency of POES (78,1%), rapid appearance of early and late climacteric symptoms is found out. The role of premorbide surgical background in the domination of hard and middle degree disturbances (56%) was showed. The hormonal profile POES was investigated in dynamics HRT estradiol. The role of large estrogen doses and potentioning gestogen effect in the rapid elimination of early climacteric symptoms was shown. We carried out the comparative analysis of modern drugs HRT (Livial, Klimonorm, Klimen, Estraderm-TTS) after ovarioectomy with or without the uterine extraction.

The frequency of caesarean section in St. Petersburg is 11,3 ~ 13,4 % from the number of parturitions. Antibiotic treatment is the specific method of prophylaxis of pyo-septical complications after operation. The comparison data on prophylactic efficiency of Cefalosporins and Augmentin infused during a surgical treatment and during the first day after a surgical treatment was made.

It is known that intravenous injection of 1,2 grams of Augmentin during and double injection of 0,6 grams at interval of 12 hours after an operation reduces the risk of postoperative complications up to 7 %, reduces the length of staying of the puerperiums in the hospital.

The experimental way proves an opportunity of perftorcarbons emulsion application for blood loss restoration at acute massive blood loss during pregnancy. The features of effects and outcome of labor at experimental animals after perftorane transfusion are investigated. The positive p erf tor carbons emulsion influence on oxygen miometrium maintenance is investigated.

At 75 patients (average age 57,2 years, average postmenopausal period 3,5 years) the hormonal replacement therapy is carried out because of climacteric syndrome with Proginova (29 women), Cyclo-Proginova (25 women) and Climen (21 women). The preparations were nominated in a cyclic mode (average duration of treatment has made 5,6 cycles).

There is marked a high therapeutic effect as reduction of frequency of vegetovascular climacteric frustrations in Proginova application (83 % ), Cyclo- Proginova (84 %) and Climen (96%).

The application of Proginova, Cyclo-Proginova and Climen resulted in normalization of lipid spectrum of blood by 3 month of treatment, that was expressed in authentic decrease in initially raised cholesterin and cholesterin of low density, with increase of the contents of cholesterin fraction of high density.

The marked normalization of lipid spectrum as a result of hormonal replacement therapy can be considered as pathogenic influence directed on normalization in age - associated metabolic infringements in female organism.

113 pregnant women with periferal nervous system diseases(PNSD) are examined. 84 of them had radiculoneuropathy: 48 - lumbosacral segment (LSS), 36 - cervicothoracal segment (CTS), 29 had single and multiple neuropathy (SMN).

Almost half cases (49,6%) the symptoms of PNSD first appeared in 2nd trimester. In the 1st trimester it took place in 28,3%, in 3rd - in 22,1%. SMN more frequently appeared in 21-28 weeks of gestation.

The pregnancy was complicated by threatened miscarriage in CTS more frequently in early gestational age, and in LSS - in 2nd trimester. SMN complicated gestosis. The correlation with professional factors is revealed.

Complex étiopathogénie treatment was carried out with use of medications, physiotherapeutic procedures, physical exercises and psychotherapy. Complete nervous function restoration was noted in 80,5%, partial - in 17,5% women.

The authors carried out the examination of 33 pregnant women with EPH- gestosis, in which complex therapy with the use of vegetative preparation «Chofitol» was included. The clinico-laboratory efficiency of a medication is shown.

Adolescent girls in the early years after their first menstruation are characterized by frequent irregular menstrual cycles and absence of ovulation, often associated with clinical signs of hyperandrogenism, including hirsutism and acne. Often in these adolescent girls, both the ovarian structure and endocrine characteristics do not allow to distinguish the disease from polycystic ovarian syndrome (PCOS) observed in adults.

The latest data in Quality-of-Life evaluation in gynecologic patients is represented in this review. One of the methods of questionnaire composition and requirements for the questionnaires are described. The scientific and practical value of Quality-of-Life evaluation in gynecology for better results of treatment is underlined.

In lecture the questions of pharmacokynetics, pharmacodynamics, indications and contra-indications for medications used with the purpose of replacement treatment in postmenopausal period are considered.

“Anatomical and physiological properties of a man are, as well known, variable, mobile and because of that under the influence of hereditary and physical environment may get improved or get worsened” V.M.Florinsky (1866).

Syndromic approach has been written in this publication. Syndromic approach is the new approach for diagnostics and treatment of sexual transmitted diseases.

The clinical case of shistozomatous salpingitis, that has become the course for primary tubal-peritoneal infertility is shown. Such diseases are rather rare for european countries, but widely spread in southern countries among women.

Perimenopause is a period of age-related decline in ovarian function, mostly after age 45, including premenopause and one year after menopause or 2 years after the last independent menstruation. Menopause is the last independent menstruation due to the function of the reproductive system. The date of menopause is set retrospectively, that is, after 12 months of no menstruation. Menopause occurs on average around the age of 50.

In recent decades, there has been a clear trend towards an increase in the life expectancy of the population. In the 1990s it reached 78.9 years for women. The global population of postmenopausal women today is 10%. According to WHO projections 46% of women are expected to be over 45 years old by 2015. The age of menopause remains fairly stable and in different regions of Russia is 49-50 years. Consequently, a woman spends more than a third of her life in a state of deficiency of female sex hormones.