Vol 2, No 6 (2014)

The article represents data about qualitative and quantitative composition of phenolic compounds in water-ethanol extract of perspective clone of Mentha longifolia L. of NBE-NSC selection. Phenolic substances content in water-ethanol extract amounted to 3003.3 mg/100g. 13 components were determined in the extract. The extract contains caffeic acid, chlorogenic acid isomers, rosmarinic acid and glycosides of luteolin. Rosmarinic acid (50.2%) prevails among phenolic substances of Mentha longifolia extract. The conclusion is that the use of this extract is possible to create products with high biological value.

The article shows the results of Saussurea involucrata Kar. et Kir. chemical content study which grows in Kazakhstan.

Decoctions of fruits, leaves, and also tendrils, roots and bark of the footstalk of the Сornus mas are used in traditional medicine. The purpose of this work is a study of morphological and anatomical signs of a footstalk and the buds of the Сornus mas for further development of standard documentation on medicinal raw materials. Morphological and аnatomical features of the footstalk and the buds of the plant were defined.

Data about content and component composition of essential oil of six species from genus Nepeta L. in the condition of South coast of the Crimea have been given for the first time. We have identified from 16 to 21 components. Specimen with cytronellol content up to 58,42% and geranilacetat content up to 14,60% have been selected.

Astragalus cicer L . is a plurannual grassy plant of Fabaceae family which is widespread on the territory of central Russia and is used in folk medicine for treatment of different diseases. The article presents the results of anatomical organization of vegetative organs of Astragalus cicer L. The revealed features of anatomical organization of stem and leaf may be used for Astragalus cicer L. raw materials diagnosis.

This article represents the results of technological researches on development of new neurotropic remedy based on water-soluble excipient of harmine hydrochloride. Peroral remedy in capsules at dose of 30 mg which correspond to pharmaceutical quality indices have been developed for the first time.

The article shows theoretic substantiation of a butaminofen suppositories production reasonability - a new drug elaborated and synthesized in Belarus State University. We have considered the prospects of butaminofen suppositories use for anogenital herpes treatment. Evidence of a substance timeliness are based on the results of pharmacological, biopharmaceutical properties analysis of butaminofen and its marketing research.

It is necessary to elaborate methods of atypical neuroleptic agents detection as individual substances and in different combinations as well for diagnosis of poisoning by some of them: clozapine, risperidone, sertindole, olanzapine, aripiprazole. The purpose of this work is methods elaboration of detection of clozapine, risperidone, sertindole, olanzapine, aripiprazole, haloperidol, oxazepam, carbamazapine using TLC, HPLC and UV spectrophotometry methods.During this work we used tablet forms of clozapine, risperidone, sertindole, olanzapine, aripiprazole. It is possible to use solution systems like ethanol-water-25% ammonia solution (8:1:1), toluol-acetone-ethanol-25% ammonia solution (45:45:7.5:2.5), dioxan-chloroform-acetone-25% ammonia solution (47.5:45:5:2.5) for preliminary examination of atypical neuroleptic agents under study in combination with typical neuroleptics and tranquilizers with undirected analysis (general screening). System of solvents ethyl-acetate-chloroform-25% ammonia solution (85:10:5) is recommended to use for individual screening of risperidone, sertindole, olanzapine, haloperidol, benzol-ethanol-25% ammonia solution (50:10:0.5) system to use for clozapine, sertindole, olanzapine. Ethanol-25% ammonia solution (100:1.5) system is reasonable to use for chromatographic clearance of extracts from biological substances under study. We recommend using HPLC method and UV spectrophotometry for carrying out of a principal examination of clozapine, risperidone, sertindole, olanzapine and aripiprazole in case one of the substances under study is determined in the object.

The articles describes the results of "Ayafrol, 3% ointment" phytopreparation bioaccessibility study on the basis of essential oil of Ajania fruticulosa for local treatment of wounds. We have studied pharmacokinetics of the phytopreparation with estimation of intensity of essential oil components general action on organism after its penetration in systemic blood. The method is based on isolated liquid extraction of substances from serum of experimental animals. The results showed that there was no cumulation of phytopreparation components in system blood in 24 hours exposition while applying it locally. High concentration of a substance may occur directly on the wound surface. Thus Ayafrol ointment components are oriented on a local action towards wounds, directly in a place of contact of wound surface.

The article presents the results of immunocorrecting properties of dry extract fractions of C. geoides (Rosaceae) for experimental immunodeficiency. Since the BAC fractions action relinquishes to the action of integral extract, the isolation of active substances is not reasonable.

Humoral and cellular factors of natural resistance in different blood vessels for experimental CCl 4-hepatitis have been studied. Sharp decrease of all factors have been detected with prevailing suppression of cellular link in lever veins and gradual increase of lysozime by 14 days which supposes the use of corresponding immunoprotectors in post-desintoxication period.

Analysis of pharmacological approaches to improve the physical health of rescue workers in emergency situations was carried out. The article talks about a new class of pharmacological tools to enhance physical activity.

The articles presents the results of antridepressant action of water-soluble form of harmine hydrochloride.

Spontaneous notifications method is frequently the principal source of information about undesirable drug reactions (UDR). Volgograd regional center of drugs safety screening has been receiving about 182 notifications a year from doctors about UDR. The majority (34%) of the notifications were about UDR of antimicrobial drugs. UDR during treatment with cardio-vascular drugs amounted to 12% of all registered UDR in the region.

The article presents the results of Vyshkovsky's index use for adsorptive intestinal preparations demand analysis. We have also considered a possibility of a new adsorption intestinal preparation launch on the Russian pharmaceutical market.

Hypotensive drugs applied by pregnant women in gestational and post-gravidary periods are limited by four basic groups of antihypertensive substances. Administration of other drugs is rare and do not have a tendency to grow. The majority of drugs corresponds to the following criteria: they are low cost, they are used during several decades. Beta-adrenergic blockers are the leaders among the hypotensive drugs for pregnant women. On the whole, pharmacotherapy of a high blood pressure of contingent under study corresponds to international recommendations.