Vol 54, No 2 (2005)

Placental tissue produces more than 100 biologically active molecules: hormones, cytokines, growth factors, enzymes, and others. The correlations between pregnant women age and expression of melatonin, prolactin, CD34, NO—synthase, HLA—DR, CD35, Mcl—1, p53 expression in villous chorion of human mature placenta have been shown. Computer image analysis is not recognized the differences in optical density and expression square values of above immunohistochemical markers either in mature and overmature pregnancy. These data demonstrate high functional activity of overmature placenta. Thus, it may be postulated that the «aging» of placenta is not connected with pregnancy duration but it is determined by the biological age of pregnant women.

The complex clinical end statistical analysis of features of current of labors in the period with 1994 for 2003 has shown, that in structure of anomalies of patrimonial activity there are authentic changes. Along with significant decrease of frequency of revealing of weakness of patrimonial activity and tendency to decrease of frequency of revealing not—coordinated of patrimonial activity frequency of revealing of fast and prompt labors essentially has increased. Diagnostics not—coordinated of patrimonial activity in the greatest degree is connected to preferences, erudition and experience of the doctor, than with real correlation of revealed attributes and symptoms specific of this pathology of labors. The precisely same attributes and symptoms are characteristic for some variants of weakness of patrimonial activity, that gives the basis to attribute both kinds of this pathology of labors to hypertonic dysfunction of uterus, in a basis of which development lays corporal—cervical dyssinergia, instead of the pathology the driver of a rhythm, as it was considered earlier.

Intact myometrium specimen, received from 56 women of reproductive age during surgical interventions. There were 30 women with combined hyperplastic processes in the reproductive system organs (uterine myoma, endometrium hyperplasia, adenomyosis, benign ovarian tumors, mastopathy, background cervical pathology), and in 26 cases solitary uterine myoma was found. At infrared spectrometry of the lyofilized myometrium, taken from patients with combined proliferation foci, a stable peak with wave number 3500 sm^—1 was found, which reflects the accumulation of molecules with oxidized OH—groups and a change in proportion of OH—/NH—containing molecules. At the study of the myometrium of patients with single myoma focus the described peak was absent. The acquired data suggests, that combined benign hyperplasias in the reproductive system organs are accompanied by the oxidative stress cascade reactions, characterized by uncontrollable production of free radicals and/or insufficiency of antiradical protection mechanisms.

The blood content of insulin—like growth factor—1 (IGF—1) in woman with ovarian hyperstimulation syndrome (OHSS) is low that may be connect with damage of synthetic function of liver. The use of synthetic analogist of somatostatin in treatment of OHSS don’t lead to reliable positive results. Low content of IGF—1 in OHSS makes pathogeneticaly non—justifight the treatment of OHSS by synthetic analogist of somatostatin.

The collection of group В streptococcal clinical strains has been analyzed for the presence of genes encoding for putative adherence and aggregation factors. The presence of the genes designated as sspB1 and sspB2 were tested by PCR and DNA hybridization. The genes under study located in GBS genome on “pathogenicity islands” were found to be heterogeneous and could be associated with urological or invasive diseases. No significant correlation between the GBS serotype and sspB genes pattern have been discovered.

Climacteric syndrom is one of the most frequent complains among females in perimenopausal period that leads to significant deterioration of health. Complex of syptoms— vegetovascular, neuro—psychick, trophic disorders and menstrual disorders is caused by age process of steroidogenesis. The use of combined estrogen—hestagen medicine in perimenopausal period is proved pathogenetically, however every fith woman has climacteric disorders during the breakes of taking two—phase replacable medicine. In this case, it is reasonable to take three— phase replacable medicine, that contain changeable dosage of estrogens throughout the whole period of treatment.

Method of isothermal amplification of nucleic acids NASBA {Nucleic Acid Sequence—Based Amplification) is becoming widely used in diagnostic molecular microbiology including diagnostics of infections in pregnant women and newborn infants. NASBA method possesses the unique ability to amplify RNA target selectively in the presence of DNA target of identical sequence, which determines its main application areas: diagnosis of RNA viruses, investigation of bacterial and viral gene expression, diagnosis of bacterial infections based on 16S rRNA detection. In the article the principle and the main steps of the method as well as some applications in diagnostic microbiology are reviewed. In addition, a comparative evaluation of NASBA and other amplification techniques such as polymerase chain reaction (PCR) and reverse—transcriptase PCR (RT—PCR) is presented.

This report is based on the analysis of the most common mistakes of antenatal care and childbirth. Materials were collected in many cities of Russia (medical faculties of universities): 3000 case histories; materials of legal medical findings; information of internet; data of correspondence questionnaire of parturients.

In the present review principles of therapy and surgical treatment of women with the polycistic ovary syndrome (PCOS) are summarised in compliance with pathogenesis. Different methods of treatment of women with the PCOS for decreasing symptoms of hyperandrogenemia, the recovery of the ovulatory function and treatment of infertility are examined.

A general description of delivery institutions in the capital of Russia on the eve of cardinal changes in political, economic and social system of the State. The artical is illustrated by a map of Saint—Petersburg with marked location of delivery institutions and explanatory table.

 A pregnancy and labour description is given for a 1st group disabled person suffering from the genetically confirmed spinal muscular atrophy type II (SMA type II). Statistically, the risk for the infant being born with SMA is less then 0,5 %. No serious complications were identified during the pregnancy; the Caesarean section was performed during the delivery. Considering the substantial atrophy of the muscular system, myorelaxants were excluded during the followed anaesthesia. A male infant was extracted without genetic pathologies, weighting 1900 g, 40 cm long, scored 7/7 by the Apgar scale. State social and community organizations provided aid in caring for the baby.

Agenda 102 people attended 1. Modern methods of operative delivery Vladimir Georgievich Pavlovich, Associate Professor of the Department of Reproductive Health of a Woman, St. Petersburg State Medical Academy of Postgraduate Education, Ph.D. Prof. B.N. Novikov, prof. Abramchenko V.V., prof. Ailamazan E.K.

The need for new textbooks arises at regular intervals with an interval of about five years. The appearance in the university library of a new textbook is each time perceived with interest and enthusiasm, both by teachers and students, since there is an opportunity to take a new step following the improvement of knowledge and the emergence of new technologies