Vol 14, No 1 (2017)
- Year: 2017
- Articles: 36
- URL: https://journals.eco-vector.com/1994-9480/issue/view/6059
Articles
CARDIOVASCULAR RISK AND INFLAMMATORY LESIONS OF JOINTS
Abstract
In this publication the problem of cardiovascular comorbidity in the most common rheumatic disorders was discussed. The pathogenesis and clinical features of cardiovascular diseases (CVD) in rheumatoid arthritis and other inflammatory lesions of joints were analyzed. Practical issues of cardiovascular risk evaluation and CVD prevention in rheumatoid arthritis patients were addressed according to the current national and EULAR guidelines. The cardiovascular safety of disease-modifying drugs, including biologics, was highlighted. Evidence-based recommendations for cardiovascular risk management in patients with inflammatory arthritis were summarized.
Journal of Volgograd State Medical University. 2017;14(1):3-9






MODERN APPROACH TO DIAGNOSTICS AND TREATMENT OF PRIMARY AND SECONDARY MYOPATHIES
Abstract
The analysis of the diagnosis and treatment of primary and secondary myopathies was perfromed. The prospects of raising awareness of their mechanisms and developing methods of pathogenetic action, capable of slowing their progress, improving the quality of life of patients and prolonging life and functional activity were demonstrated.
Journal of Volgograd State Medical University. 2017;14(1):16-22



DIFFERENTIATED ADMINISTRATION OF CYTOPROTECTORS IN PATIENTS WITH CHRONIC HEART FAILURE AND TYPE 2 DIABETES MELLITUS
Journal of Volgograd State Medical University. 2017;14(1):23-26



ANALYSIS OF COMPLICATIONS AND PSYCHOEMOTIONAL STATUS IN CHILDREN OF THE VOLGOGRAD REGION WITH TYPE 1 DIABETES MELLITUS USING DIFFERENT METHODS OF INSULIN DELIVERY
Abstract
The analysis of the timing of complications in children with type 1 diabetes mellitus was performed depending on the methods of insulin delivery. The structure of complications in patients with a short history of the primary disease was determined. The most common complications include fatty liver disease, diabetic polyneuropathy, both when syringes and pumping insulin therapy are used. The severity of anxiety and depressive syndrome in children with type 1 diabetes depends on the duration of the disease, the degree of its compensation, and the presence of complications.
Journal of Volgograd State Medical University. 2017;14(1):27-29



MODELING STREPTOZOTOCIN-INDUCED TYPE 2 DIABETES MELLITUS IN RATS ON A HIGH-FAT DIET
Abstract
Type 2 diabetes mellitus (T2DM) is a complex heterogeneous disease linked with genetic predisposition and lifestyle, especially dietary component. Developing an experimental animal model of T2DM is reguired to elucidate its pathogenesis and develop novel antidiabetic agents.
Journal of Volgograd State Medical University. 2017;14(1):30-32



STUDY OF ACUTE TOXICITY OF CITROCARD, A NEW DERIVATIVE OF FENIBUT WITH A CARDIO- AND NEUROPROTECTIVE ACTION
Abstract
The experiments on fertile mice and rats have demonstrated that citrocard refers to the class of low-toxic agents (class IV toxicity, Russian national standard GOST 12.1.007-76). When administered intraperitoneally, the limits of LD50 of citrocard reach 2143,0 (1967,0-2334,8) mg/kg in female mice, in males - 2324,1 (2119,4-2548,6) mg/kg; in female rats 1491,1 (1361,8-1632.6) mg/kg, in males - 1708,5 (1456,0-2004,9) mg/kg. Intragastric administration to mice yielded more than 4000,0 mg/kg, to rats - 3500 (3250,1-3769,1) mg/kg.
Journal of Volgograd State Medical University. 2017;14(1):33-35



CHANGES IN CEREBRAL BLOOD FLOW IN RATS WITH EXPERIMENTAL STENOSIS OF COMMON CAROTID ARTERIES
Abstract
The changes in cerebral blood flow in rats with experimental stenosis of the common carotid arteries were assessed in this study Cerebral blood flow was measured immediately after a 50 % reduction of blood vessel diameter, 20 days and 40 days after the surgery. We demonstrated that the cerebral blood flow was 29 % lower than that in intact animals measured on 20 and 40 days after the surgery.
Journal of Volgograd State Medical University. 2017;14(1):36-39



PHARMACOECONOMIC ANALYSIS OF NEW ORAL ANTICOAGULANTS IN VTE
Abstract
The findings of pharmacoeconomic analysis of novel anticoagulants in the treatment of venous thromboembolism are presented. Rivaroxaban, apixaban and dabigatran have proved to lower health care costs as compared to conventional treatment. Budget impact analysis has demonstrated that the introduction of novel anticoagulants can reduce healthcare costs by more than 3 million rubles.
Journal of Volgograd State Medical University. 2017;14(1):40-45



EFFECTS OF HUMAN y-INTERFERON AND CD4 GLYCOPROTEIN ANTIBODIES ON THE IMMUNE SYSTEM INDICES IN HIV-INFECTED PATIENTS
Abstract
The present article provides the findings of the study of the impact of human y-interferon and CD4 glycoprotein antibodies on the immune system of HIV-infected patients. The combined administration of the standard antiretroviral therapy and the antibodies has been found to result in an increase in CD3+ and CD4+ cells. These changes were associated with the stimulation of y-interferon, IL-2 and IL-4 secretion.
Journal of Volgograd State Medical University. 2017;14(1):46-49



CORRELATION BETWEEN PROINFLAMMATORY MARKERS OF ENDOTHELIAL ACTIVATION AND FIBRINOLYSIS SYSTEMS IN PATIENTS WITH ATHEROSCLEROSIS OBLITERANS OF LOWER LIMBS BEFORE AND AFTER SURGERY
Abstract
The analysis the correlation between proinflammatory activation markers (homocysteine, oxidized lipoprotein of low density, sVCAM-1, Annexin V) and fibrinolytic activity (PAI-1, t-PA) was conducted in patients with arteriosclerosis obliterans of the lower extremities before and after surgery. The revealed correlations between inflammatory marker concentration and increased prothrombotic capacity at the systemic level and in the affected limb remained significant even after reconstructive surgery.
Journal of Volgograd State Medical University. 2017;14(1):50-53



EXPERIMENTAL STUDY OF DOSE-DEPENDENT ENDOTHELIOTROPIC EFFECT OF ATACL IN ISCHEMIC BRAIN DAMAGE IN RATS
Abstract
The study found that the ATACL compound has the most pronounced endotelioprotective effect when administered at a dose of 100 mg/kg. The pharmacological effect of the administration of this dose of ATACL was comparable with the effect of sulodexide
Journal of Volgograd State Medical University. 2017;14(1):54-58



ISOLATION, DETECTION AND QUANTIFICATION OF ALIMEMAZINE IN MODEL MIXTURES OF URINE, SALIVE AND BLOOD PLASMA
Abstract
The article presents the study of the techniques of detecting and quantifying mixtures in models of alimemazine urine, saliva and blood plasma. To isolate alimemazine from biological fluids a method of liquid-liquid extraction analyzing the physicochemical properties of the analyte has been suggested. The detection was carried out using TLC and HPLC quantification - HPLC.
Journal of Volgograd State Medical University. 2017;14(1):59-61



DEVELOPING TECHNIQUES OF ISOLATING, DETECTING AND QUANTIFYING FLUPENTIXOL IN MODEL SAMPLES OF LIVER AND KIDNEYS
Abstract
An optimal technique of isolating, detecting and quantifying flupentixol in model samples of liver and kidneys has been developed. The degree of extraction of flupentixol using conventional methods has been estimated.
Journal of Volgograd State Medical University. 2017;14(1):62-65



MORPHOSTRUCTURAL CHANGES IN ABUTMENT TEETH OF FIXED PROSTHESES USING THE METHOD OF VITAL AMPUTATION (EXPERIMENTAL STUDY)
Abstract
The morphostructural changes in pulp and periodontium of abutment teeth in fixed prosthesis were experimentally studied using the method of vital amputation and application of Pulpotec over the period of 1,3 months. Compensatory and proliferative changes involving formation of apically directed fibrosis connective tissue were detected in the pulp. No sings of inflammation were revealed. The periodontium showed an increase in collagen fibers, a decrease in the cellular components as compared to the reference (control) teeth. Increased calcification of cementum and bone matrix was also observed. All these modifications are due to changes in the mineral metabolism, and adaptive restructuring of PDL, caused by increased functional load on the abutment teeth coated with cast crowns.
Journal of Volgograd State Medical University. 2017;14(1):66-68



METALLOPROTEINASES 1 AND 13 AS MARKERS OF DESTRUCTIVE AND PROLIFERATIVE PROCESSES IN THE ARTICULAR CARTILAGE IN EXPERIMENTAL OSTEOARTHRITIS
Abstract
The present study investigated the dynamics of the activity of MMP-1 and MMP-13 hyaline cartilage in rats with experimental osteoarthritis of the knee which was followed by a comparative analysis of the data with morphometric parameters.
Journal of Volgograd State Medical University. 2017;14(1):69-73



LONG-TERM RESULTS OF PROBIOTICS USE AND BALNEOTHERAPY IN COMPREHENSIVE TREATMENT OF BACTERIAL VAGINOSIS. A COMPARATIVE STUDY
Abstract
The efficacy of probiotics, containing lactobacillus сaseir hamnosus spp., and balneotherapy in comprehensive treatment of bacterial vaginosis (BV) was evaluated. 107 patients were examined. 51 patients were given probiotics and 56 patients were treated with balneological factors (mud and brine) after receiving Imidazole antimicrobial therapy Complaints, data of objective examination, pH-metry, smear microscopy, bacteriological investigation and a semiquantitative method of a real-time polymerase chain reaction were analyzed to evaluate the efficiency of treatment. After balneological treatment at its second stage, a considerable increase in lactobacillus pool was revealed in a long-term perspective. It was 2.5 times higher than that after probiotics (p < 0,01) were used in conventional treatments to restore the vaginal tract.
Journal of Volgograd State Medical University. 2017;14(1):74-77



COMPARATIVE ANALYSIS OF THE EFFECTIVENESS OF VISUAL METHODS OF DIAGNOSIS IN PATIENTS WITH OSTEONECROSIS AND ASEPTIC OSTEOMYELITIS OF JAW BONES
Abstract
The article presents a comparative analysis of the results of the visual methods of diagnostics of drug-induced osteonecrosis and aseptic osteomyelitis of jaw bones. The diagnostic information value of endovascular angiography as the most objective test as compared to other existing diagnostic tools has been confirmed. The comparison of rheological and morphological indicators in the lesions has proved high efficiency of the endovascular method of diagnosis. The obtained results of treatment of drug-induced aseptic osteonecrosis and osteomyelitis suggest that this diagnostic test is the most objective tool, they help to justify the choice of the most rational method of surgical intervention, predict its results, and optimize rehabilitation terms.
Journal of Volgograd State Medical University. 2017;14(1):78-82



DEPENDENCE OF BIOIMPEDANCE INDICATORS ON WAIST TO HIP RATIO IN OBESE PATIENTS
Abstract
Body composition analysis considering preferred fat mass localization was performed in obese patients at the premises of Healthy Food Center (Samara) using an ABC-01 MEDASS component analyzer. The indices whose values are different in upper and lower/homogenous types of obesity have been defined which is important for further diet therapy.
Journal of Volgograd State Medical University. 2017;14(1):83-86



CORNEAL SATURATION WITH RIBOFLAVIN DURING CORNEAL CROSS-LINKING OF COLLAGEN
Abstract
A comparative analysis of corneal saturation with a riboflavin solution using the standard and modified CXL protocols was performed in ex vivo 20 porcine corneas. The study has proved that riboflavin similarly absorbs into and saturates the corneal stroma when standard and modified protocols for CXL are used.
Journal of Volgograd State Medical University. 2017;14(1):87-91



COMPARATIVE EVALUATION OF VISUAL AND REFRACTIVE OUTCOMES AFTER CORRECTING MODERATE MYOPIA WITH FEMTOLASIK METHOD USING DIFFERENT FEMTOSECOND LASERS
Abstract
The comparative evaluation of visual and refractive outcomes of correcting moderate myopia with FemtoLASIK using femtosecond systems (Femto Visum, Russia and Femto LDV Z6, Switzerland) was performed. No statistical difference between both systems (p > 0,05) was revealed.
Journal of Volgograd State Medical University. 2017;14(1):92-94



VISUAL OUTCOMES OF THE TOPOGRAPHY-GUIDED FEMTOLASIK IN MYOPIC ASTIGMATISM CORRECTION
Abstract
The clinical and functional outcomes of the topography-guided laser correction (T-CAT technology) were evaluated in patients with myopic astigmatism. The topography-guided FemtoLASIK (T-CAT technology) surgery has proved to be a safe and effective method of laser correction.
Journal of Volgograd State Medical University. 2017;14(1):95-97



THE VALUE OF CONFOCAL MICROSCOPY BY SELECTION OF ORTHOKERATOLOGY CONTACT LENSES IN PATIENTS WITH MYOPIA
Abstract
Confocal microscopy was performed to evaluate initial state of the cornea in 48 myopic patients (96 eyes). Measurements were repeated in the setting of orthokeratological contact lenses application. It was determined that confocal microscopy allows estimating safety of orthokeratological lens application in a specific patient with consideration to histomorphological state of the cornea.
Journal of Volgograd State Medical University. 2017;14(1):98-100



LONG-TERM RESULTS OF EXCIMER LASERSURGERY AFTER THE APPLICATION OF ORTHOKERATOLOGY LENSES
Abstract
We studied the results of LASIK surgery in 20 patients (40 eyes) who preoperatively applied orthokeratologic contact lenses (the first group) and 23 patients (46 eyes) who preoperatively applied only spectacle correction. Refractive stability after LASIK was observed in both groups at all stages of monitoring. Corneal changes in patients applying orthokeratologic lenses have a transient nature and do not affect the results of LASIK surgery.
Journal of Volgograd State Medical University. 2017;14(1):101-102



CIRCULAR TUNNEL FEMTO CROSSLINKING IN THE TREATMENT OF PATIENTS WITH PROGRESSIVE KERATOCONUS
Abstract
127 eyes of 116 patients with progressive keratoconus stage 1-2 (classification Amsler-Krumeich), were divided into 2 groups depending on the method of CXL. The main group included 64 eyes underwent the procedure CTFCXL using femtosecond laser. The control group consisted of 63 eyes undergone standard CXL. The main and control group were divided into 2 subgroups: the 1st subgroup - eyes with I stage of keratoconus. 2nd subgroup - eyes with II stage. CTFCXL is an effective method for stabilization progressive keratoconus at 3 years of follow-up, providing improved of functional indicators comparable with the standard CXL, and minimizing the risk of complications.
Journal of Volgograd State Medical University. 2017;14(1):103-107



SMILE POST SMILE - A NEW APPROACH TO THE CORRECTION OF RESIDUAL MYOPIA
Abstract
We observed good refractive and functional effects in all patients three months following the surgery. An improvement in visual acuity within the first day postoperatively was reported in patients who underwent Circle and SPS. Overall patient satisfaction with clinical outcomes and preservation of the biomechanical properties of the cornea were reported in patients who underwent SPS. The clinical results of SPS surgery (Smile post Smile) indicate that SPS is a highly effective, painless and safe surgical procedure to correct residual myopia.
Journal of Volgograd State Medical University. 2017;14(1):108-110



ANALYSIS OF HISTOMORPHOLOGICAL CHANGES IN THE CORNEA FOLLOWING SURGERY
Journal of Volgograd State Medical University. 2017;14(1):111-113



MORPHOLOGICAL FEATURES OF THE BUCCAL MUCOSA IN FEMALE STUDENTS IN VARIOUS PHASES OF THE MENSTRUAL CYCLE IN THE BELGOROD REGION
Abstract
We studied morphological features of the buccal epithelium in female students in various phases of the menstrual cycle (proliferation and secretion) in the Belgorod region. The results showed that hormonal fluctuations lead to changes in the composition of the buccal mucosa. The prevalence of typical buccal epithelial cells is associated with a predominance of estrogen during the proliferation phase. Identification of leukocyte clusters and groups of horny scales points to morphological changes induced by progesterone in the secretion phase. An increase in the area of epithelial cell nuclei and cytoplasm in buccal mucosa as well as an increased nuclear and cytoplasmic index in the secretory phase, as compared with the proliferation phase, can be accounted for by enhanced synthetic activity of the cells induced by progesterone.
Journal of Volgograd State Medical University. 2017;14(1):114-116



MICROINVASIVE FEMTOSECOND LASER POSTERIOR LAMELLAR KERATOPLASTY USING AN ULTRA-THIN GRAFT
Abstract
Five female patients (5 eyes) have been operated on for secondary endothelial corneal dystrophy accompanied by pseudophakia using a posterior lamellar femtosecond laser keratoplasty and a 70-micron thickness corneal graft. The 70-micron thickness graft which was formed using a femtosecond laser has been reported to hold the potential to survive sufficiently long after posterior lamellar keratoplasty and provides good structural and functional outcomes.
Journal of Volgograd State Medical University. 2017;14(1):117-118



OPTIMIZED DEEP ANTERIOR LAMELLAR KERATOPLASTY(DALK) USING A FEMTOSECOND LASER
Abstract
We investigated 44 patients (44 eyes) with confirmed diagnosis of keratoconus stage III. We found that the use of a femtosecond laser for DALK provides in-depth air separation and enhances the frequency of formation of a «Big bubble» air bubble, thus reducing the risk of conversion to a penetrating procedure.
Journal of Volgograd State Medical University. 2017;14(1):119-120



A CASE REPORT OF PRIMARY CORNEAL GRAFT FAILURE FOLLOWING PENETRATING KERATOPLASTY
Abstract
In case of primary corneal graft failure following penetrating keratoplasty, conservative treatment approaches appear to have no effect. The only treatment option in this situation is early-stage regrafting. To reduce the likelihood of immune conflicts, it is appropriate to apply topical immunosuppressant medications (cyclosporine eye drops 0,05%) postoperatively.
Journal of Volgograd State Medical University. 2017;14(1):121-123



THE TECHNIQUE FOR EVALUATING AND DEVELOPING PSYCHO-PHYSIOLOGICAL FEATURES REQUIRED TO MAKE GOOD DRIVERS OF PASSENGER SERVICE VEHICLES
Abstract
An expert evaluation technique allowed us to establish that professionally important sensorimotor skills and abilities as well as the characteristics of higher nervous activity are required to ensure good performance of the drivers of passenger service vehicles.
Journal of Volgograd State Medical University. 2017;14(1):124-126



RATIONALE FOR INTRAOSSEOUS INFUSION IN CLINICAL DENTISTRY
Abstract
We studied variant anatomy of the dentomaxillary (192) and dentomandibular segments (1040). We defined the ideal intraosseous needle injection site, the pattern of the spread of the fluid which is administered intraosseously from the site of injection. The use of an intraosseous needle injection site depends on the localization of the pathological focus.
Journal of Volgograd State Medical University. 2017;14(1):127-130



RELATIONSHIP BETWEEN SOME MORPHOFUNCTIONAL PARAMETERS OF THE HAND AND SOMATOTYPE OF 17-21-YEAR-OLD BOYS
Abstract
The article deals with the relationship of morphological and functional parameters of the hand and somatotype in 17- 21-year-old boys. The research was conducted using new HandScaner software which was developed by the authors. The purpose of the research was to identify the relationship between somatotype and morphofunctional parameters of the hand in the young males. A positive correlation was found between the force of the hand and the square of its palmar surface in the asthenic group. A less close correlation was found between the force of the hand and the length of the middle finger in the normosthenic group. We established that the relationship between palmometric data and dynamometric indicators, as evidenced by literature, appears to be age-related.
Journal of Volgograd State Medical University. 2017;14(1):131-133



NATIONAL CLINICAL RECOMMENDATIONS FOR OBESITY: CONCEPT AND PROSPECTS
Abstract
The article deals with metabolic and hemodynamic disorders, as well as the pathologics of organs and systems associated with obesity. The prerequisites for the creation of new national clinical guidelines «Diagnosis, treatment, prevention of obesity and related diseases» are given.
Journal of Volgograd State Medical University. 2017;14(1):134-140



Pravila dlya avtorov
Journal of Volgograd State Medical University. 2017;14(1):144-144


