Vol 13, No 2 (2016)
- Year: 2016
- Articles: 35
- URL: https://journals.eco-vector.com/1994-9480/issue/view/6055
Articles
NEW CRITERIA FOR RHEUMATIC FEVER DIAGNOSIS (REVISED STATEMENT OF THE JONES CRITERIA FROM THE AMERICAN HEART ASSOCIATION)
Abstract
The present article considered the modified Jones Criteria proposed by AHA. The main purpose of the revision was to increase the sensitivity of Jones Criteria by including Doppler echocardiography as a tool to diagnose cardiac involvement. Another reason to update them was current epidemiology of rheumatic fever, which should be taken into account while diagnosing RF. Advantages and disadvantages of the revised criteria were discussed. On the basis of the performed analysis one can conclude that the revised Jones criteria could not be applied in Russian clinical practice without any preliminary evaluation. Moreover, the revised Jones criteria should be thoroughly discussed by Russian national experts so as to produce consensus regarding the usefulness of these modifications and their inclusion in the national guidelines for diagnosing acute rheumatic fever.
Journal of Volgograd State Medical University. 2016;13(2):3-7
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NONALCOHOLIC FATTY LIVER DISEASE AS A MULTISYSTEM DISEASE
Abstract
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. Over the last decade, it has been shown that the clinical burden of NAFLD is not only confined to liver-related morbidity and mortality, but there is now growing evidence that NAFLD is a multisystem disease, affecting extra-hepatic organs. For example, NAFLD increases risk of type 2 diabetes mellitus (T2DM), cardiovascular (CVD) and cardiac diseases, and chronic kidney disease (CKD). The review discusses the factors involved in the progression of liver disease in NAFLD and the factors linking NAFLD with other extrahepatic chronic diseases, such as CVD and CKD.
Journal of Volgograd State Medical University. 2016;13(2):8-14
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EXPERIENCE IN THE TREATMENT OF PATIENTS WITH ANKYLOSING SPONDYLITIS IN THE VOLGOGRAD REGION
Abstract
We analyzed the use of the main methods of treatment of patients with ankylosing spondylitis on in the Volgograd region. The study demonstrated a significant role of early diagnosis of the disease and of administration of adequate therapy Higher effectiveness of genetically engineered biological products was observed.
Journal of Volgograd State Medical University. 2016;13(2):15-17
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QUALITY IMPROVEMENT OF PHARMACOTHERAPY OF COMMUNITY-ACQUIRED PNEUMONIA IN PEDIATRIC HOSPITAL
Abstract
Pharmacotherapy of community-acquired pneumonia in in-patient children's healthcare institution was analyzed, some organizational instruments of increasing the quality of medical care under the current legislation are being offered, i.e. the compliance with medical care standards and clinical guidelines. A map of monitoring pharmacotherapy implementation may serve as an instrument of increasing the quality of medical care.
Journal of Volgograd State Medical University. 2016;13(2):18-21
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DEVELOPMENT AND INITIAL VALIDATION OF A QUESTIONNAIRE TO STUDY DISEASE ACTIVITY IN SYSTEMIC LUPUS ERYTHEMATOSUS
Abstract
Current work presents the results of development and initial validation of a questionnaire for self-assessment of disease activity in systemic lupus erythematosus (SLE) patients. Three-stage process provided formulation of an initial questionnaire, further improvement after application in different SLE patients and assessment of external, content and divergent validity as well as reproducibility in a cohort of 30 SLE patients with various disease activity. Good correlation with valid SLE activity indices was demonstrated and no correlation with damage was seen. Reliability analysis have shown acceptable internal consistency of a new questionnaire.
Journal of Volgograd State Medical University. 2016;13(2):22-26
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PHARMACOLOGICAL CORRECTION OF ASTHENIC SYNDROME AND QUALITY OF LIFE IN PATIENTS WITH DIABETES MELLITUS TYPE 2 WITH PERIPHERAL NEUROPATHY
Abstract
Evaluation of the effect of treatment with meldonium in patients with type 2 diabetes with peripheral sensorimotor neuropathy on the severity of asthenic syndrome, quality of life, clinical manifestations of neuropathy It was observed the significant reduction such symptoms as common mental and physical fatigue, improve performance, reflecting the quality of life and severity of neuropathy
Journal of Volgograd State Medical University. 2016;13(2):27-31
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INFECTIOUS COMPLICATIONS OF EARLY POSTOPERATIVE PERIOD IN PATIENTS AFTER KIDNEY TRANSPLANTATION
Abstract
We studied the microbial flora in various biological media in infectious complications in renal transplant recipients. There was a slight predominance of gram-positive flora. In most cases, the isolated bacteria showed a pronounced polyvalent antibiotic resistance.
Journal of Volgograd State Medical University. 2016;13(2):32-35
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PHARMACEUTIST AWARENESS OF HYPOLIPIDEMIC DRUGS IN THE VOLGOGRAD REGION
Abstract
The article analyzes the data on pharmaceutist awareness of the assortment and pharmacological effects of hypolipidemic drugs in the Volgograd region. Despite an extensive assortment of hypolipidemic drugs, pharmaceutists are unaware of the side effects and drug interactions of this group of drugs.
Journal of Volgograd State Medical University. 2016;13(2):36-40
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RELATIONSHIP BETWEEN POLYMORPHISM OF THE CYP2D6 GENE AND EFFICACY AND SAFETY PROFILE OF HALOPERIDOL IN PATIENTS WITH ALCOHOLADDICTION
Abstract
Haloperidol is used to control the use of alcohol; however, dose adjustment often results in serious side effects. CYP2D6 enzyme, which is encoded by CYP2D6 gene, has a highly variable activity caused by CYP2D6, a genetic polymorphism. The study included 20 males with alcohol addiction. We evaluated the efficacy and safety of haloperidol using international psychometric scales. A real-time PCR method was used for CYP2D6 genotyping. The study revealed statistically significant patterns between CYP2D6 polymorphism and haloperidol efficacy and safety.
Journal of Volgograd State Medical University. 2016;13(2):41-44
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EPIDEMIOLOGICAL PROFILE OF HIV-INFECTED PREGNANT WOMEN IN THE VOLGOGRAD REGION
Abstract
The article presents data on the structure and level of morbidity of HIV-infected pregnant women in the Volgograd region, the risk of mother-to-child transmission of HIV, and the impact of chemoprophylaxis in pregnant women.
Journal of Volgograd State Medical University. 2016;13(2):45-47
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PROBLEMS OF PHARMACOLOGICAL THERAPY OF NICOTINE DEPENDENCE IN MEDICAL PROFESSIONALS
Abstract
We studied the efficacy and safety of varenicline in medical professionals with nicotine dependence. One third of the respondents quitted smoking entirely after the prescribed course of treatment with varenicline. The varenicline efficacy in nicotine dependence therapy in medical professionals was evaluated to be satisfactory.
Journal of Volgograd State Medical University. 2016;13(2):48-49
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GENDER AND SOMATIC FEATURES OF THE FUNCTIONAL STATUS IN STUDENTS
Abstract
A total of 191 girls aged 16-20 years and 175 boys aged 17-21 years were evaluated. There is a tendency towards an increase in the central hemodynamic parameters from asthenic to hypersthenic in both males and females. We also found more pronounced adaptive-compensatory abilities of the body in asthenic girls.
Journal of Volgograd State Medical University. 2016;13(2):54-57
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METROLOGICAL ASPECTS OF SEMIOTICS AND DIAGNOSTICS OF ACUTE SURGICAL DISEASES OF THE ABDOMINAL ORGANS: A SYSTEMATIC APPROACH TO SEMIOTICS AND DIAGNOSTICS IN EMERGENCY ABDOMINAL SURGERY
Abstract
The use of minimally invasive surgical techniques promoted further research into diagnostic aspects of metrological evaluation in the semiotics of emergency minimally invasive surgery. It should be noted that the methods of identifying serious intra-abdominal pathology have changed significantly However, for a variety of diseases such as acute cholecystitis or pancreatic necrosis visual inspection of the peritoneal cavity is no longer used. Diagnostics of such diseases is based on interpretation of clinical, instrumental and laparoscopic findings.
Journal of Volgograd State Medical University. 2016;13(2):58-62
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TREATMENT OF STRABISMUS ACCOMPANIED BY DEFICIENT SUPERIOR OBLIQUE MUSCLE USING INFERIOR OBLIQUE MUSCLE Z MYOTOMY AND RADIOWAVE SURGERY
Abstract
The article describes the results of surgical treatment of strabismus accompanied by deficient superior oblique muscle using inferior oblique muscle Z myotomy and radiowave surgery. The analysis showed that inferior oblique muscle Z myotomy with the use of radio waves is a safe and effective method of treating strabismus accompanied by deficient superior oblique muscle grades 1 and 2.
Journal of Volgograd State Medical University. 2016;13(2):63-66
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EVALUATION OF THE RESULTS OF FEMORAL-POPLITEAL BYPASS IN PATIENTS WITH ATHEROSCLEROSIS OBLITERANS FROM A MICROCIRCULATION VIEW
Abstract
The features of microcirculation in patients with atherosclerosis obliterans having lesions in the femoral-popliteal segment before and after reconstructive surgery were explored. We revealed a decrease in microcirculation, changes in the active modulation mechanisms of blood flow, impaired microvascular reactivity during the occlusion test.
Journal of Volgograd State Medical University. 2016;13(2):67-69
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THE EVALUATION OF THE MARKETING POTENTIAL OF THE EXOSCELETON «EXAR»
Abstract
The features, competitive advantages and market capacity of the exoskeleton «Exar» are studied in the paper as well as economic, law and political risks of its market placement. The authors also compare similar products (not substitutes) of domestic and international producers.
Journal of Volgograd State Medical University. 2016;13(2):70-73
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PULMONARY TUBERCULOSIS IN THE VOLGOGRAD REGION IN 1997-2014
Abstract
Tuberculosis (TB) epidemiology in the Volgograd region has been gradually improving in the last 18 years, but it still remains very tense In the last years a decrease in the epidemiological indicators of tuberculosis has been accelerating. Over the last ten years the morbidity of residents has decreased by 23,8 % and mortality - by 40,1 %.
Journal of Volgograd State Medical University. 2016;13(2):78-80
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EXPERIMENTAL EVALUATION OF PHARMACOLOGICAL NEUROPROTECTION DURING SURGERY ON BRACHIOCEPHALIC ARTERIES
Abstract
Experimentally, we modeled temporary brain ischemia in rats, occurring during a surgical intervention on carotids. Popular cerebroprotectors and the medications undergoing preclinical studies were used for brain protection. The evaluation was performed, based on NOS1, NOS3, TRAIL expression. We concluded that the neuroprotectors were effective during the surgery on brachiocephalic arteries.
Journal of Volgograd State Medical University. 2016;13(2):85-86
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ENSEMBLE DISCRIMINANT ANALYSIS OF RELATIONSHIPS BETWEEN NHE-1 INHIBITORYACTIVITY OF CYCLIC GUANIDINS AND THE ELECTRONIC PARAMETERS OF GUANIDINE FRAGMENT
Abstract
In silico relationships between NHE-1 inhibitory activity of cyclic guanidins (N9-imidazo[1,2-a]benzimidazoles and 2-aminobenzimidazoles) and the electronic parameters of guanidine fragment using ensemble discriminant analysis were revealed.
Journal of Volgograd State Medical University. 2016;13(2):87-90
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OPERATIVE TREATMENT OF THE III-IV STAGE POSTTRAUMATIC OSTEOARTHRITIS OF THE ANKLE JOINT
Abstract
A comparative clinical, biomechanical and radiological examination of 74 patients in the period from 1 year to 13 years after arthrodesis and joint replacement of the ankle at the III-IV stage of osteoarthrosis was performed.
Journal of Volgograd State Medical University. 2016;13(2):94-96
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EVALUATION OF STROMAL RIBOFLAVIN ABSORPTION USING A MODIFIED CXL PROTOCOL FOR THE TREATMENT OF PROGRESSIVE KERATOCONUS
Abstract
The compared corneal saturation with riboflavin solution while using the standard and modified CXL protocols in ex vivo 20 porcine corneas. The study showed that absorption of riboflavin into the corneal stroma under standard and modified protocols for CXL was similar.
Journal of Volgograd State Medical University. 2016;13(2):97-100
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ANALGETIC ACTIVITY OF A BENZIMIDAZOLE DERIVATIVE ON MODELS OF INFLAMMATORY PAIN
Abstract
We studied the analgesic activity of RU-1205, a benzimidazole derivative, on the models of inflammatory pain. The derivative has been found to exhibit pronounced analgesic activity in both acute and chronic experimental pain models.
Journal of Volgograd State Medical University. 2016;13(2):101-103
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CHARACTERISTICS OF INTEGRATIVE CONJUGATIVE ELEMENTS OF NON-CHOLERAE VIBRIO STRAINS IN THE VOLGOGRAD REGION
Abstract
Integrative conjugative elements (ICEs) belonging to the SXT/R391 family were identified in Vibrio spp. strains isolated from open water in the Volgograd region. Four Vibrio spp. strains were found to contain recombinant ICEs.
Journal of Volgograd State Medical University. 2016;13(2):104-106
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CEREBRAL CIRCULATION IN HEALTHY INDIVIDUALS WITH DIFFERENT TYPES OF CEREBRAL MICROCIRCULATION IN THE WEDGE AND ORTHOSTASIS
Abstract
The cohort analysis of cerebral circulation in healthy individuals revealed negative changes in the tone of resistance cerebral arteries as well as in regional blood flow in hypo- and hypertonic types of cerebral hemodynamics in orthostasis, which are thought to play a critical role in early diagnostics of cardiovascular diseases.
Journal of Volgograd State Medical University. 2016;13(2):107-110
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NARINGIN AND APIGENIN IMPROVE ENDOTHELIAL VASODILATOR FUNCTION OF BRAIN VESSELS IN EXPERIMENTAL ANIMALS WITH FOCAL ISCHEMIA
Abstract
The study describes the effects of naringin and apigenin on endothelial vasodilator function (EVF) of cerebral vessels after ischemia. The experiment was carried out on Wistar male rats. Focal ischemia was induced by occlusion of the middle cerebral artery. We used Doppler sonography to assess EVF through modifying NO synthesis. We used sulodexide (Vessel Due F, Alfa Wasserman, Italy) and mexidol (Pharmasoft, Russia) as reference drugs. Our findings suggest that both naringin and apigenin can protect EVF in rats after brain ischemia. The animals which received naringin and apigenin showed that administration of acetylcholine improved vasodilation by 1,6 and 2.2 (p < 0.05) times, respectively, as compared with negative controls. Moreover, the use of naringin and apigenin resulted in diminished vascular response (increased blood flow) caused by L-arginine administration. L-NAME-mediated vasoconstriction was more pronounced in rats treated with naringin and apigenin than in negative controls. Nonetheless, apigenin showed pharmacological effects superior to those of naringin and comparable to those of the reference drugs, sulodexide and mexidol.
Journal of Volgograd State Medical University. 2016;13(2):111-114
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DIAGNOSTICS OF MICROCIRCULATION IN ORAL INFLAMMATORY DISEASES
Abstract
High prevalence of periodontal disease and increased treatment needs pose a challenge for dentists. The prevalence of vitamin D deficiency ranges 1 % - 78 % in different age groups. High vitamin D-deficiency levels associated with increased prevalence of oral diseases need to be considered when selecting an appropriate therapy with vitamin D metabolites. We studied blood supply to the oral cavity in patients with mild chronic generalized periodontitis accompanied by vitamin D deficiency The oral mucosa showed hyperemic microcirculation characterized by increased microvascular blood flow, increased vascular permeability, stagnation areas in periodontal tissues.
Journal of Volgograd State Medical University. 2016;13(2):115-118
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POSSIBLE ROLE OF ADAPTATION MECHANISMS OF THE AUTONOMIC NERVOUS SYSTEM IN GASTROINTESTINAL AND URINARY TRACT DISORDERS IN CHILDREN
Abstract
Childhood exposure to multiple risk factors is characterized by malformations and malfunctions in any of the body's systems, particularly in the nervous and immune systems. Malfunction of the immune system interfering with the functioning of the body's nervous system underlies disadaptation mechanisms which can cause gastrointestinal and urinary tract disorders.
Journal of Volgograd State Medical University. 2016;13(2):119-121
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SINGLE-DOSE TOXICITY STUDY OF RU-185 (ENOXIFOL) IN RATS
Abstract
LD50 values were 1920.96 mg/kg (1858.47÷1985.55 mg/kg) for male rats and 2260.3 (2294.69÷2226.39) mg/kg for female rats after intragastric administration of toxic doses of RU -185. Based on classification criteria for acute toxicity (GOST 12.1.007-76), we allocated this substance to a moderately toxic drug category. We evaluated functional and behavioral effects of RU-185 on rats and established that its minimum pharmacological activity was observed at a dose of 1.9 mg/kg, while the maximum - at a dose of 59-119 mg/kg. Taking into account the LD50 values and the range of pharmacological activity recorded for RU-185, we calculated the therapeutic index of enoxifol and it equaled 1000. Within the given therapeutic index, the range of pharmacological activity that is safe equals 240, while the range of toxic activity equals 475-1000. We suggest that the data on enoxifol toxicity and the ranges of its pharmacological and toxic activities could be used for dose selection/adjustment in subsequent preclinical toxicity studies.
Journal of Volgograd State Medical University. 2016;13(2):122-126
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ANALYSIS OF NONLINEAR DYNAMICS IN THE MICROVASCULATURE IN CHILDREN WITH TYPE 1 DIABETES BY LASER DOPPLER FLOWMETER
Abstract
Comprehensive analysis of the nonlinear parameters, evaluating the form and self-similarity of the attractor (fractal analysis), randomness and regularity of the trajectories of the system (entropy), the reconstruction of the likely structure of space, complexity and randomness of the system (phase portrait, the correlation regularity of the attractor) was conducted in children with type 1 diabetes (diabetes type 1). The study revealed the characteristics of the macroscopic behavior of the aggregate factors modulating blood flow.
Journal of Volgograd State Medical University. 2016;13(2):127-131
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FACTORS AFFECTING THE QT INTERVAL DURATION IN CHILDREN WITH TYPE 1 DIABETES AND THE ABILITY TO PREDICT ITS ELONGATION
Abstract
Analysis standard electrocardiograms in children with type 1 diabetes (DM type 1) with an estimate of the QT interval, with the calculation of corrected QT interval and dispersion was conducted. Factors affecting the duration of the QT interval in children with type 1 diabetes have been identified. A mathematical model for predicting the time of QTc interval prolongation with the debut of type 1 diabetes, according to microcirculatory disorders diagnosed by LDF has been developed.
Journal of Volgograd State Medical University. 2016;13(2):132-135
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THE USE OF SODIUM HYPOCHLORITE IN NON-ALCOHOLIC STEATOHEPATITIS
Abstract
31 patients with non-alcoholic steatohepatitis (NASH) received monotherapy with sodium hypochlorite infusions. We measured the levels of lipid peroxidation, antioxidative enzyme activity, citolytic and mesenchymal inflammatory syndrome at baseline and upon completion of the treatment. All indices as well as the general condition of the patients improved after treatment with sodium hypochlorite. We conclude that treatment with sodium hypochlorite appears to be an effective option in treating NASH.
Journal of Volgograd State Medical University. 2016;13(2):136-139
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