Vol 13, No 2 (2016)

The present article considered the modified Jones Criteria proposed by AHA. The main purpose of the revision was to increase the sensitivity of Jones Criteria by including Doppler echocardiography as a tool to diagnose cardiac involvement. Another reason to update them was current epidemiology of rheumatic fever, which should be taken into account while diagnosing RF. Advantages and disadvantages of the revised criteria were discussed. On the basis of the performed analysis one can conclude that the revised Jones criteria could not be applied in Russian clinical practice without any preliminary evaluation. Moreover, the revised Jones criteria should be thoroughly discussed by Russian national experts so as to produce consensus regarding the usefulness of these modifications and their inclusion in the national guidelines for diagnosing acute rheumatic fever.

We analyzed the use of the main methods of treatment of patients with ankylosing spondylitis on in the Volgograd region. The study demonstrated a significant role of early diagnosis of the disease and of administration of adequate therapy Higher effectiveness of genetically engineered biological products was observed.

Current work presents the results of development and initial validation of a questionnaire for self-assessment of disease activity in systemic lupus erythematosus (SLE) patients. Three-stage process provided formulation of an initial questionnaire, further improvement after application in different SLE patients and assessment of external, content and divergent validity as well as reproducibility in a cohort of 30 SLE patients with various disease activity. Good correlation with valid SLE activity indices was demonstrated and no correlation with damage was seen. Reliability analysis have shown acceptable internal consistency of a new questionnaire.

We studied the microbial flora in various biological media in infectious complications in renal transplant recipients. There was a slight predominance of gram-positive flora. In most cases, the isolated bacteria showed a pronounced polyvalent antibiotic resistance.

Haloperidol is used to control the use of alcohol; however, dose adjustment often results in serious side effects. CYP2D6 enzyme, which is encoded by CYP2D6 gene, has a highly variable activity caused by CYP2D6, a genetic polymorphism. The study included 20 males with alcohol addiction. We evaluated the efficacy and safety of haloperidol using international psychometric scales. A real-time PCR method was used for CYP2D6 genotyping. The study revealed statistically significant patterns between CYP2D6 polymorphism and haloperidol efficacy and safety.

We studied the efficacy and safety of varenicline in medical professionals with nicotine dependence. One third of the respondents quitted smoking entirely after the prescribed course of treatment with varenicline. The varenicline efficacy in nicotine dependence therapy in medical professionals was evaluated to be satisfactory.

A total of 191 girls aged 16-20 years and 175 boys aged 17-21 years were evaluated. There is a tendency towards an increase in the central hemodynamic parameters from asthenic to hypersthenic in both males and females. We also found more pronounced adaptive-compensatory abilities of the body in asthenic girls.

The article describes the results of surgical treatment of strabismus accompanied by deficient superior oblique muscle using inferior oblique muscle Z myotomy and radiowave surgery. The analysis showed that inferior oblique muscle Z myotomy with the use of radio waves is a safe and effective method of treating strabismus accompanied by deficient superior oblique muscle grades 1 and 2.

The features, competitive advantages and market capacity of the exoskeleton «Exar» are studied in the paper as well as economic, law and political risks of its market placement. The authors also compare similar products (not substitutes) of domestic and international producers.

Tuberculosis (TB) epidemiology in the Volgograd region has been gradually improving in the last 18 years, but it still remains very tense In the last years a decrease in the epidemiological indicators of tuberculosis has been accelerating. Over the last ten years the morbidity of residents has decreased by 23,8 % and mortality - by 40,1 %.

Experimentally, we modeled temporary brain ischemia in rats, occurring during a surgical intervention on carotids. Popular cerebroprotectors and the medications undergoing preclinical studies were used for brain protection. The evaluation was performed, based on NOS1, NOS3, TRAIL expression. We concluded that the neuroprotectors were effective during the surgery on brachiocephalic arteries.

We studied the structure of the wholesale range of phlebotropic drugs represented on the pharmaceutical market of the Stavropol Territory. We also worked out a meso-contour on the basis of the results obtained.

The compared corneal saturation with riboflavin solution while using the standard and modified CXL protocols in ex vivo 20 porcine corneas. The study showed that absorption of riboflavin into the corneal stroma under standard and modified protocols for CXL was similar.

Integrative conjugative elements (ICEs) belonging to the SXT/R391 family were identified in Vibrio spp. strains isolated from open water in the Volgograd region. Four Vibrio spp. strains were found to contain recombinant ICEs.

The study describes the effects of naringin and apigenin on endothelial vasodilator function (EVF) of cerebral vessels after ischemia. The experiment was carried out on Wistar male rats. Focal ischemia was induced by occlusion of the middle cerebral artery. We used Doppler sonography to assess EVF through modifying NO synthesis. We used sulodexide (Vessel Due F, Alfa Wasserman, Italy) and mexidol (Pharmasoft, Russia) as reference drugs. Our findings suggest that both naringin and apigenin can protect EVF in rats after brain ischemia. The animals which received naringin and apigenin showed that administration of acetylcholine improved vasodilation by 1,6 and 2.2 (p < 0.05) times, respectively, as compared with negative controls. Moreover, the use of naringin and apigenin resulted in diminished vascular response (increased blood flow) caused by L-arginine administration. L-NAME-mediated vasoconstriction was more pronounced in rats treated with naringin and apigenin than in negative controls. Nonetheless, apigenin showed pharmacological effects superior to those of naringin and comparable to those of the reference drugs, sulodexide and mexidol.

Childhood exposure to multiple risk factors is characterized by malformations and malfunctions in any of the body's systems, particularly in the nervous and immune systems. Malfunction of the immune system interfering with the functioning of the body's nervous system underlies disadaptation mechanisms which can cause gastrointestinal and urinary tract disorders.

Comprehensive analysis of the nonlinear parameters, evaluating the form and self-similarity of the attractor (fractal analysis), randomness and regularity of the trajectories of the system (entropy), the reconstruction of the likely structure of space, complexity and randomness of the system (phase portrait, the correlation regularity of the attractor) was conducted in children with type 1 diabetes (diabetes type 1). The study revealed the characteristics of the macroscopic behavior of the aggregate factors modulating blood flow.

31 patients with non-alcoholic steatohepatitis (NASH) received monotherapy with sodium hypochlorite infusions. We measured the levels of lipid peroxidation, antioxidative enzyme activity, citolytic and mesenchymal inflammatory syndrome at baseline and upon completion of the treatment. All indices as well as the general condition of the patients improved after treatment with sodium hypochlorite. We conclude that treatment with sodium hypochlorite appears to be an effective option in treating NASH.