Vol 11, No 3 (2014)

Vertebral basilar insufficiency is a multidisciplinary problem. The lecture discusses current approaches to diagnosis and treatment of acute and chronic insufficiency of vertebral basilar system.

The present study provides data on the dynamics of biometals including zinc and copper in patients with acute coronary syndrome depending on the extent of myocardial infarction. The concentration of zinc in blood serum in all groups of patients with acute coronary syndrome on admission was significantly lower, while that of copper was higher than in the control group. These changes were proportional to the extent of myocardial infarction and were most pronounced in patients with Q wave myocardial infarction.

A 12-week, prospective, randomized, open, comparative, parallel-group study was performed. The study included 50 children with uncontrolled and partially controlled atopic asthma and laboratory diagnosis of magnesium deficiency. Objective: to evaluate the efficacy of pharmacotherapy of bronchial asthma (BA) in children receiving magnesium deficiency treatment. Magnesium B6 Forte was used to treat concomitant magnesium deficiency. The effectiveness of pharmacotherapy was evaluated within 12 weeks based on the level of asthma control, frequency of exacerbations and the number of days on which the patient had no symptoms. The dynamics of the severity of allergic inflammation was evaluated using a monthly monitoring system of the levels of nitric oxide in the exhaled air (FeNO). Conclusion: The effectiveness of BA pharmacotherapy was enhanced in children receiving magnesium deficiency treatment.

In this paper, the method of substructure analysis was used to investigate the relationship between the levels of hypoglycemic activity and chemical structure of basic cyclic guanidine. A class of N 9-substituted 2,3-dihydro-imidazo[1,2-a]benzimidazole, as the most promising as to the possible presence of compounds with hypoglycemic activity was identified.

The article analyzed the progress of the indicators of morbidity and prevalence of the diseases affecting the reproductive health of children and adolescents in the Volgograd region in 2010-2012. It provided the data on pregnancy termination in adolescents as well as on the incidence of the infections which are mainly sexually transmitted.

In occluded descending branch of the left coronary artery the RGPU-207 compound exerted a maximal antiischemic effect at a dose of 9,38 mg/kg which was proved by a 56 % decrease in the area under the curve of ST segment as compared with the negative control group. The compared drugs of verapamil at a dose of 1,64 mg/kg, ivabradine at a dose of 21 mg/kg and mexidol at a dose of 40 mg/kg reduced the area under the curve of ST segment by 50, 38 and 41 % respectively The tested compound exhibited an antiarrhythmic action, reducing the severity of reperfusion arrhythmias as compared to verapamil and surpassed ivabradine and mexidol.

The article explored new ways of in-depth diagnostics of the morphofunctional state of athletes' heart. The research found a number of considerable changes in diastolic and systolic left ventricular dimensions, functional characteristics as well as its posterior wall depending on the specialization of athletes and their gender.

We demonstrated that the number of cells expressing vimentin and smooth muscle actin cells in the liver tissue was rapidly increasing in the first 4 weeks. After 8 weeks of progressing fibrosis the number of vimentin positive cells was stabilized and the number of actin positive cells continued to grow.

We demonstrated that medical care providers who are maximum risk-takers show the presence of emotional intelligence which is by 29,8 % higher than that in moderate risk-takers' group; their alpha-rhythm is 3 times as prominent in the frontal leads according to the index and their low-frequency beta-rhythm is 3,3 times as prominent in the central leads according to the index.

During a pharmacoepidemiological study we established that ACE-inhibitors (34,8 %) and diuretics (30 %) were predominantly administered to patients with diabetes type 2 associated with essential hypertension receiving treatment in outpatient clinics of Volgograd and Volzhsky as compared to other antihypertensive drugs. This treatment fully conforms with the guidelines and standards of arterial hypertension treatment. However, the rate of administration of centrally acting adrenergic drugs was rather low (3,4 %) which needs to be corrected.

Application of a drainage implant (HealaFlow) in surgical treatment of glaucoma was shown to have a good hypotensive effect. This implant is easy to use and makes it possible to preserve subconjunctival and intrascleral spaces.

The study aimed to determine allelic polymorphisms of CYP3A5, MDR1 and IL-2 genes in kidney recipients receiving cyclosporine A, with and without episodes of pneumonia in the post-transplant period.

The relationship between functional changes of the placenta, which were revealed with Doppler investigation of pregnant women, and morphological changes of afterbirth tissue in patients with uncomplicated pyelonephritis has been established.

The possibility of prognosticating the level of induction of Ah-receptor in human lymphocytes when exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin was demonstrated by studying the spontaneous and induced activity of Ah-receptor in human and animals lymphocytes in vitro and in vivo.

The article presents the findings of agent's role macrophage migration inhibitory factor in prediction of the coarse and outcome alimentary tract upper part diseases in children.

Results of morphological study of various peritoneum departments condition after drawing the standardized operational trauma of various volume are reported in article. Using the offered by authors morphometric criteria the dynamics of postoperative changes of thickness, numerical density of mesotheliocytes, diameter of their nuclei and an indicator of a surface parietal peritoneum of pelvic region of the right lateral channel, a diaphragm and visceral peritoneum of a small intestine are presented.

According to the pharmacoeconomical analysis «The costs of illness» of ambulatory care of diabetes mellitus type 2 which was hold in outpatient clinics in the city of Volgograd and Volzhsky it was established that there are far more costs of the comorbidities of diabetes mellitus type 2(19554,3 ± 406,5) RUB in comparison with other costs of diabetes. The biggest part of these costs goes to macroangiopathy (80 %). The first place among these costs belongs to arterial hypertension (60,4 %). All in all the drug therapy of comorbidities corresponds to the clinical guidelines and standarts but, however, needs to be corrected. According to the costs the first place in the treatment of arterial hypertension belongs to β-adrenoblockers (48,1 %) while ACE-inhibitors, angiotensin II receptor blockers and agonosts to I1-receptors are more recommended by russian and foreign guidelines in this case.

45 patients with inflammatory diseases of the pelvic organs and a confirmed diagnosis of «chronic endometritis» were examined. After examination of the control group patients underwent combined therapy based on the detected pathogens, followed by hormonal correction, and patients of the main group was assigned a combined therapy: Integrated treatment with local injection of drugs into the uterus and pelvic organs with subsequent hormonal correction. After the regular menses in most patients in the control group experienced a relapse, and patients of the main group in 48 % of cases observed recovery of reproductive function.

The influence of developing an experimental colon tumors on the thymus in rats. Established that the number of mature medullar thymocytes remains constant during carcinogenesis, in contrast to age-atrophy of thymus, where their number is reduced. Also in tumorogenesis notes an increases number of neuroendocrine and neuroectodermal cells in thymocite microenvironment. This suggests that during carcinogenesis, along with signs of atrophy of the thymic parenchyma there are signs of conservation timopoesis together as opposed to age involution in which the production of thymocytes is reduced.