卷 16, 编号 1 (2019)

The methods of children's behavior management are discussed in the article. Pharmacological and non-pharmacological techniques of children's behavior management are analyzed. The algorithm of dental care for children with negative behavior is described. It includes home training (role-playing and art-therapy) and gradual involvement of the children in the dental treatment process. It substantiates the importance of an individual approach to children's behavior management.

Infusion of crystalloids solutions is one of most frequently administered types of therapeutic interventions in patients undergoing surgical operations. The goal of the current prospective randomized clinical study was to compare the effects of acetate-based balanced solution Ionosteril® (group 1) and non-balanced 0,9% NaCl solution (group 2) on acid-base balance and hemodynamic stability within 48 hours of intra- and post-operative period in patients undergoing abdominal surgical operations. Levels of chloremia and base excess (BE) were set as primary end-point indicating the severity of metabolic acid-base disturbances. Hemodynamic parameters and kidney function markers (creatinine, cystatin C) was also assessed in dynamics. The infusion of acetate-based balanced solution resulted in much less severe acid-base disturbances, particularly more stable pH and serum bicarbonate levels with no signs of base deficit. Patients administered 0,9% NaCl solution had statistically higher level of hyperchloremia and concurrent metabolic acidosis. Based on the levels of cystatin C as biomarker of early kidney damage, intra- and post-operation kidney function seem to be more stable in the group of patients treated with Ionosteril . Therefore admistration of acetate-based crystalloid solution appears to be more rational choice for prevention of hypovolemia and maintaining hemodynamic stability in patients undergoing abdominal surgical procedures.

In this study we made comparison of the accuracy of linear and angular parameters according to the data of lateral cephalometry got with the computer software (OnyxCeph3TM version 3.2.100) and manual method at the stage of orthodontic treatment diagnosis and planning and also the possibility of usage of OnyxCeph3TM software was shown for purposes of easing and fastening oral and maxillofacial pathology diagnosis when planning orthodontic treatment.

The case of erosive and ulcerative lichen planus is described in the article. Effective drug treatment is suggested. The successful interaction of dentists and dermatovenerologists in treatment of patients with lichen planus of skin and oral cavity is demonstrated.

The article presents the results of the effect on the vasodilating function of the endothelium of complex treatment of patients with arterial hypertension stage II with identified situational depression living in Donbas. Additional inclusion in the standard antihypertensive pharmacotherapy of the psychotherapeutic complex auto-training + functional music + L-arginine (0,75 once a day) has been shown to effectively eliminate vascular endothelial dysfunction, which was manifested by a change in the diameter of the brachial artery (p < 0,001) in response to an increase in speed blood flow (p < 0,05) after external occlusion in this group of patients after 24 weeks of treatment is similar to the change in healthy volunteers (p < 0,05).

Introduction. The study of the risk factors that lead to the development of cerebral palsy enables new approaches for the prevention and early detection of the disease. Purpose of the study. To assess the significance of the influence of perinatal factors on the development of cerebral palsy in children. Materials and methods: retrospective study of primary medical records and surveying of mothers. Results. In the group of children with cerebral palsy the antenatal period was accompanied by obstetric pathology, miscarriages and abortions in the anamnesis of the mothers; the intranatal period - by weak or impetuous labor, a tight umbilical cord around the neck and asphyxia; the postnatal period - by prematurity, low birth weight, low Apgar score, development of jaundice, seizures, apnea and the need for tracheal intubation. Conclusion. Children with the above-mentioned factors should be included in the risk group for the development of cerebral palsy.

In the comparative aspect, the clinical efficacy of modern topical mucoadhesive drugs belonging to different types of transport systems of local drug delivery was studied. The study included 90 patients with erosive form of red flat lichen of the oral cavity, in the local treatment of which traditional forms (ointment) of drugs and drugs with high mucoadhesive properties (gel and polymer film) were used. The results of the study demonstrate the most active nature of epithelialization and regression of inflammation of oral mucosa in patients using mucoadhesive drugs, and justifies their use as a local therapeutic system.

A wide choice of methods for obtaining impressions from a large number of installed dental implants leads to the question of the effectiveness and accuracy of existing methods. An accuracy assessment of the fit of the permanent prosthetic restorations based on parallel-installed dental implants was carried out after receiving the impressions with a standard closed tray, an individual open tray without splinting impression copings, splinting impression copings over and under the open tray. The accuracy of the transfer of the dental implants position was estimated by the size of the gap that occurs when fitting a permanent restoration. The smallest gap, (0,241 ± 0,06) mm, was detected using an open tray with splinting impression copings under the tray. It provides the most accurate result of the transfer of the dental implants position installed in parallel in comparison with other methods of obtaining impressions.

As a result of in vitro screening studies to search for the possible antidiabetic activity of a number of azoloazine derivatives, it was found that the compounds are capable of moderate inhibition of dipeptidylpeptidase-4 (DPP-4), inhibiting the enzyme activity by an average of 60 % at a concentration of 100 цМ, which is inferior actions of the reference drug vildagliptin (more than 99 % of the suppression of the activity of DPP-4 at the same concentration). The compounds are also able to significantly slow down glycation of bovine serum albumin (BSA) (the series leader - compound 1c suppresses the glycation reaction of BSA by 74 % at a concentration of 1 mM, compared to 58 % inhibition for the reference compound aminoguanidine). It was not possible to establish the ability of compounds to bind (chelate) Cu2+ in the ascorbic acid autooxidation test, except for compound 1k (it slowed down the reaction by 49 % at a concentration of 40 цМ, which is comparable in activity to the reference drug pioglitazone and is slightly more active than lipoic acid). The restriction for establishing the copper-binding activity of other members of the series is due to the high light absorption at the working wavelength of 265 nm and is not a criterion for excluding chelating properties. The results allow us to conclude that the class of compounds is a promising basis for the further development of tools with anti-glycating activity based on the structures of the representatives of the series.

During the classroom, intermediate control of knowledge and during the exam studies of the dynamics of pulse blood filling of the brain, the tone of the resistive arteries and conditions of cerebral venous outflow of blood of students of higher educational institutions. The majority of persons showed negative changes in the tone of the resistive arteries of the brain and difficulty in venous outflow of blood during various forms of knowledge control. Changes in cerebral blood flow are most significant during the exam. In the period of exam develops situational tachycardia, sympathetic tone. This negatively affects the tone of the resistive arteries of the brain and venous blood flow. The development of situational sympathicotonia must be considered when follow-up surveys of students.

One of the common inflammatory and destructive diseases in gerontostomatology is lichen planus. The course of this pathology is long, persistent and chronic. Early methods of diagnosing the disease, timely pharmacotherapy are the key to success in the treatment of lichen planus. Cytological method of research refers to the methods by which you can quickly get the results and adjust the scheme of drug symptomatic treatment of erosive and ulcerative lesions in the oral cavity. It is based on the study of the structural features of cellular elements. In this work, we examined and treated 60 patients with erosive-ulcerative form. In 30 people, in addition to traditional treatment, Titol's applications with a 0,1 % betamethasone solution are included in the scheme of complex therapy; in the second half of the patients, applications of betamethasone, fixed using a mucoadhesive polymer film, are used. In the resulting scrapings under magnification of x400 and x1000, the evaluation of the stage of destruction of epithelial cells with the corresponding morphological characteristic was made. In both cases, a positive trend was noted, however, the cytological picture was different depending on the type of drug therapy.

The article presents data on the price interest of visitors in the implementation of a set of programs to build adherence to the pharmacy. The analysis of the types of programs used in the network pharmacy organizations, the frequency of their use was conducted and using the questionnaire revealed the attitude of the visitors to them.

During the operation of enterprises for the production of energy-intensive materials, hazardous chemicals can be released into the production and environment, where they can have a negative impact on the health of the personnel of the enterprise and residents of nearby communities. Nitroglycerin, ammonium perchlorate, aluminum and trinitrotoluene make the most significant contribution to the pollution of the working environment. In the atmospheric air of the territory adjacent to the object under study, in different years, excess of the maximum single concentrations of ammonium perchlorate and aluminum oxide were recorded.

The 5-НТ2А antagonistic, M-cholinergic, histaminergic and GABA-ergic properties of 9-diethylaminoethyl-2-(4-methoxyphenyl) imidazo [1,2-α] benzimidazole dihydrochloride - RU-31 compounds with antimigraine properties were studied. Moderate M-anticholinergic and GABA mimetic action and no effect on histaminergic system were shown for RU-31 compound in vivo models in vitro.

The ability to determine the localization of nervous system disorders plays a central role in neurological diagnosis. Undoubtedly, the introduction of computer tomography and magnetic resonance imaging into medical practice was the significant advance in clinical diagnostics. However, neurovisualization often requires reinforcement with a description of disease clinical manifestations. The article describes the possibilities of the program developed by the authors for recognizing the most probable localization of the nervous system affected area and evaluating the available symptoms and signs in the chance theory terms of specific disease presence.

One of the most current problems of modern dentistry is the functional pathology of the temporomandibular joint (TMJ), caused by a malfunction of the masticatory muscles. Most clinicians agree on the need for programmed coordination of the work of the masticatory muscles and the relative position of the TMJ elements in order to determine the «true» central ratio which will be the starting point for the design of therapeutic occlusal splints. As part of the study, the possibilities of deprogrammatization techniques used in the diagnosis and treatment of functional pathology of TMJ were studied.