Vol 16, No 1 (2019)

Articles

BISPHOSPHONATE-RELATED OSTEONECROSIS OF THE JAW

Fomichev E.V., Kirpichnikov M.V., Yarygina E.N., Podolsky V.V., Nesterov A.A.

Abstract

Bisphosphonates (BPs) are a class of drug used to treat osteoporosis and malignant bone metastasis. BPs show high binding capacity to the bone matrix, especially in sites of active bone metabolism. According to modern data, bisphosphonate osteonecrosis of the jaws (BPONJ) is a complication of antiresorptive therapy, characterized by death and exposure of the bone area, which persists for more than 8 weeks, with subsequent progression of the process, provided there is no radiation therapy on the head area in history. BRONJ can adversely affect quality of life, as it may produce significant morbidity. The purpose of this article is to offer a perspective on how dentists should manage patients on BPs, and to present diagnostic aids and treatment s strategies to the condition.

Journal of Volgograd State Medical University. 2019;16(1):3-8
pages 3-8 views

CHILDREN'S BEHAVIOR MANAGEMENT DURING DENTAL SERVISE PROVIDING

Maslak E.E., Fomenko I.V., Arjenovskaya E.N., Fursik D.I., Kurkina O.N., Ogonyan V.R., Skorikova L.A.

Abstract

The methods of children's behavior management are discussed in the article. Pharmacological and non-pharmacological techniques of children's behavior management are analyzed. The algorithm of dental care for children with negative behavior is described. It includes home training (role-playing and art-therapy) and gradual involvement of the children in the dental treatment process. It substantiates the importance of an individual approach to children's behavior management.

Journal of Volgograd State Medical University. 2019;16(1):9-12
pages 9-12 views

TREATMENT OF SHIGELLOSIS IN PATIENS OF ADVANCED AND SENILE AGE

Loannidi E.A., Alexandrov O.V., Popov S.F.

Abstract

The brief clinical and epidemiological analysis of incidence of shigellosis among patients of advanced and senile age in the Volgograd region for the period from 2014 to 2017 has shown in the paper. The main approaches to etiopathogenetic and symptomatic treatment of elderly patients with shigellosis have been illustrated in the article.

Journal of Volgograd State Medical University. 2019;16(1):13-15
pages 13-15 views

CLINICAL USAGE OF BALANCED CRYSTALLOID SOLUTION IONOSTERIL IN PATIENTS UNDERGOING ABDOMINAL SURGICAL OPERATION

Kazantsev D.A., Popov A.S., Strygin A.V., Morkovin E.I., Tolkachev B.E.

Abstract

Infusion of crystalloids solutions is one of most frequently administered types of therapeutic interventions in patients undergoing surgical operations. The goal of the current prospective randomized clinical study was to compare the effects of acetate-based balanced solution Ionosteril® (group 1) and non-balanced 0,9% NaCl solution (group 2) on acid-base balance and hemodynamic stability within 48 hours of intra- and post-operative period in patients undergoing abdominal surgical operations. Levels of chloremia and base excess (BE) were set as primary end-point indicating the severity of metabolic acid-base disturbances. Hemodynamic parameters and kidney function markers (creatinine, cystatin C) was also assessed in dynamics. The infusion of acetate-based balanced solution resulted in much less severe acid-base disturbances, particularly more stable pH and serum bicarbonate levels with no signs of base deficit. Patients administered 0,9% NaCl solution had statistically higher level of hyperchloremia and concurrent metabolic acidosis. Based on the levels of cystatin C as biomarker of early kidney damage, intra- and post-operation kidney function seem to be more stable in the group of patients treated with Ionosteril . Therefore admistration of acetate-based crystalloid solution appears to be more rational choice for prevention of hypovolemia and maintaining hemodynamic stability in patients undergoing abdominal surgical procedures.

Journal of Volgograd State Medical University. 2019;16(1):16-22
pages 16-22 views

ANALYSIS OF ANGULAR DEFLECTIONS BETWEEN THE AXIS OF IMPLANTS INSTALLED BY THE METHOD OF FREE HANDS

YAblokov A.E., Ivaschenko A.V., Fedyaev I.M., Tlustenko V.P., Kolganov I.N., Samutkina M.G.

Abstract

Currently, the standard of implant quality is the use of cylindrical or cone-shaped dental implants. The strength with which the implant is inserted should not be more than 45-50 Ncm. Osteointegration occurs 3-4 months after implantation on the lower jaw and 4-6 months on the upper. When setting up a dental implant, you should observe the permissible angle of inclination of their axis - up to 5-7°. Deviation from this range creates difficulties in the subsequent prosthetics, as well as violates the aesthetics and functionality. If the implant loading is incorrectly calculated, there are changes in the bone tissue surrounding the implant, up to its resorption. Materials and methods. The collection of clinical material was carried out on the basis of the SFM of SamSMU in the period from 2015 to 2018. Implantation was performed in 32 people using the «free hand» technique. Negative results of implantation were observed in patients entering the age group of 45-65 years. Periimplantitis was observed in the projection of the missing tooth 2,2 (d implant 3,75*8,0), tooth 3.5 (d implant 3,75*11,5). All implanted implants belonged to «MISS». Conclusions. As a result of the analysis of the obtained data, it can be concluded that the largest distribution of angular deviations was observed in the sagittal plane, in contrast to the frontal, which is probably due to the peculiarities of the anatomical structure of the wrist joint.

Journal of Volgograd State Medical University. 2019;16(1):23-25
pages 23-25 views

POTENTIAL OF ONYXCEPH3™ COMPUTER SOFTWARE AT THE STAGE OF ORTHODONTIC TREATMENT DIAGNOSIS AND PLANNING

Klimova N.N., Botasheva A.R., Khvan A.A.

Abstract

In this study we made comparison of the accuracy of linear and angular parameters according to the data of lateral cephalometry got with the computer software (OnyxCeph3TM version 3.2.100) and manual method at the stage of orthodontic treatment diagnosis and planning and also the possibility of usage of OnyxCeph3TM software was shown for purposes of easing and fastening oral and maxillofacial pathology diagnosis when planning orthodontic treatment.

Journal of Volgograd State Medical University. 2019;16(1):26-29
pages 26-29 views

STUDY OF PECULIARITIES OF HIGHER NERVOUS ACTIVITY OF SCHOOLCHILDREN WITH DEVIATIONS IN MENTAL DEVELOPMENT

Marinina M.G., Nadezhkina E.Y., Fedoseeva S.Y.

Abstract

The article studies the various attention properties of students in the general education school and children who have deviations in mental development with different types of higher nervous activity. The study revealed significantly low differences in all indicators of students' attention with deviations in mental development, in comparison with children from the general education school.

Journal of Volgograd State Medical University. 2019;16(1):30-33
pages 30-33 views

THE CASE OF SUCCESSFUL TREATMENT OF PATIENT WITH EROSIVE AND ULCERATIVE LICHEN RUBER PLANUS

Mikhalchenko V.F., Ivanova I.N.

Abstract

The case of erosive and ulcerative lichen planus is described in the article. Effective drug treatment is suggested. The successful interaction of dentists and dermatovenerologists in treatment of patients with lichen planus of skin and oral cavity is demonstrated.

Journal of Volgograd State Medical University. 2019;16(1):34-36
pages 34-36 views

RESEARCH OF PECULIARITIES OF EXTERNAL BREATH AND VARIABILITY OF HEART RHYTHM IN STUDENTS WITH VARIOUS TYPES OF THE CONSTITUTION

Muzhychenko M.V., Nadezhkina E.Y., Novikova E.I., Shcherbakova T.G.

Abstract

The article is devoted to the study of lung ventilation parameters and heart rate variability in students of different somatotypes. The constitutional conditionality of the investigated indicators is revealed.

Journal of Volgograd State Medical University. 2019;16(1):37-40
pages 37-40 views

INFLUENCE OF COMBINATION THERAPY ON THE FUNCTIONAL CONDITION OF VASCULAR ENDOTHELIAL IN PATIENTS WITH ARTERIAL HYPERTENSION WITH SITUATION DEPRESSION LIVING ON DONBASS

Nalyotova O.S.

Abstract

The article presents the results of the effect on the vasodilating function of the endothelium of complex treatment of patients with arterial hypertension stage II with identified situational depression living in Donbas. Additional inclusion in the standard antihypertensive pharmacotherapy of the psychotherapeutic complex auto-training + functional music + L-arginine (0,75 once a day) has been shown to effectively eliminate vascular endothelial dysfunction, which was manifested by a change in the diameter of the brachial artery (p < 0,001) in response to an increase in speed blood flow (p < 0,05) after external occlusion in this group of patients after 24 weeks of treatment is similar to the change in healthy volunteers (p < 0,05).

Journal of Volgograd State Medical University. 2019;16(1):41-45
pages 41-45 views

PATENT LANDSCAPING IN THE ANALYSIS OF WORLD TECHNOLOGICAL TRENDS: PERFUME AND COSMETICS SEGMENT

Nemyatykh O.D., Fitisova A.I., Medvedeva D.M., Vasyagina Y.A.

Abstract

This research is dedicated to the identification and systematization of global trends in the field of perfumery and cosmetics to assess the degree of their innovative attractiveness in the Russian cosmetics market. The analysis was carried out using the Patentscope of World Intellectual Property Organization (WIPO) database as the main search tool for the period from 01.01.2006 to 01.01.2017. It has been established that the innovation vectors are mainly aimed at creating skin and hair care products. China occupies a leading position in the number of patents (26 %), the Russian Federation covers 2 % of the total number of patents for the analysed period.

Journal of Volgograd State Medical University. 2019;16(1):46-50
pages 46-50 views

INFLUENCE OF PERINATAL FACTORS ON THE RISK OF CEREBRAL PALSY IN CHILDREN IN ROSTOV REGION

Orlova E.V., Dudnikova E.V., Chernova M.S.

Abstract

Introduction. The study of the risk factors that lead to the development of cerebral palsy enables new approaches for the prevention and early detection of the disease. Purpose of the study. To assess the significance of the influence of perinatal factors on the development of cerebral palsy in children. Materials and methods: retrospective study of primary medical records and surveying of mothers. Results. In the group of children with cerebral palsy the antenatal period was accompanied by obstetric pathology, miscarriages and abortions in the anamnesis of the mothers; the intranatal period - by weak or impetuous labor, a tight umbilical cord around the neck and asphyxia; the postnatal period - by prematurity, low birth weight, low Apgar score, development of jaundice, seizures, apnea and the need for tracheal intubation. Conclusion. Children with the above-mentioned factors should be included in the risk group for the development of cerebral palsy.

Journal of Volgograd State Medical University. 2019;16(1):51-54
pages 51-54 views

DIAGNOSTIC INFORMATIVITY OF IMMUNOHISTOCHEMICAL BIOMARKERS IN CONDUCTING PRIVATIC PATHOLOGICAL AND ANATOMICAL RESEARCH OF PROSTATE CANCER

Smirnov A.V., Perlin D.V., Ekova M.R., Gurov D.Y., Aleksandrova L.I., Zamaraev V.S., Samusev R.P., Rogova L.N.

Abstract

The results of an in vivo pathoanatomical differential diagnosis of primary acinar adenocarcinoma of the prostate and benign lesions of the prostate gland were analyzed using a transrectal biopsy of the prostate gland using an optimized panel of antibodies to high-molecular cytokeratins (clone 34βE12), protein P63, AMACR, PSA and/or PSRA. The greatest diagnostic informativity of the basal cell differentiation marker of the columnar prostate epithelial cells was shown. The use of this set of biomarkers contributes to the establishment of a correct diagnosis and, in addition to the routine morphological examination of the biopsy material, can be recommended for carrying out an intravital pathologic anatomic differential diagnosis of prostate cancer.

Journal of Volgograd State Medical University. 2019;16(1):55-58
pages 55-58 views

EFFICIENCY OF TOPICAL APPLICATION OF MUCOADHESIVE DRUGS FOR TREATING RED FLAT LICHEN OF THE ORAL CAVITY

Firsova I.V., Fedotova Y.M., Porojskij S.V., Makedonova Y.A., Mihalchenko V.F.

Abstract

In the comparative aspect, the clinical efficacy of modern topical mucoadhesive drugs belonging to different types of transport systems of local drug delivery was studied. The study included 90 patients with erosive form of red flat lichen of the oral cavity, in the local treatment of which traditional forms (ointment) of drugs and drugs with high mucoadhesive properties (gel and polymer film) were used. The results of the study demonstrate the most active nature of epithelialization and regression of inflammation of oral mucosa in patients using mucoadhesive drugs, and justifies their use as a local therapeutic system.

Journal of Volgograd State Medical University. 2019;16(1):59-64
pages 59-64 views

CLINICAL TRIAL OF NATURAL COMBINATION THERAPIES IN THE TREATMENT OF CHRONIC GENERALIZED PERIODONTITIS OF MODERATE SEVERITY

Sharonova N.A., Temkin E.S., Poroshin A.V.

Abstract

Inflammatory periodontal diseases are widespread all over the world, occupying a leading place among pathologies leading to loss of teeth and disruption of the body as a whole. In Russia, about 98 % of the population is affected by the disease. The connection of periopathology with somatic diseases, the absence of a long lasting effect after treatment, frequent exacerbations, the appearance of allergic reactions to the drugs used, justified the search for new drugs of natural origin that have a minimal toxic effect, expressed by pharmacological properties, locally penetrating into the deeper layers of tissues. The drug of choice was a combination: a magnesium-containing medicinal preparation «Polycatan» and an aquacomplex of glycerol solvate of titanium «Tizol». As a result of the influence of the mineral-containing combination, the inflammatory process was more quickly stopped, the vascular bed normalized, the clinical and index indicators stabilized, and the patients improved their overall treatment of the periodontal disease.

Journal of Volgograd State Medical University. 2019;16(1):65-68
pages 65-68 views

ANALYSIS OF THE FILLING ACCURACY OF THE PERMANENT PROSTHETIC RESTORATIONS BASED ON DENTAL IMPLANTS DEPENDING ON THE METHODS OF OBTAINING THE IMPRESSION

Shemonaev V.I., Mashkov A.V., Patrushev A.S., Lashakova A.V., Zhivotov D.S.

Abstract

A wide choice of methods for obtaining impressions from a large number of installed dental implants leads to the question of the effectiveness and accuracy of existing methods. An accuracy assessment of the fit of the permanent prosthetic restorations based on parallel-installed dental implants was carried out after receiving the impressions with a standard closed tray, an individual open tray without splinting impression copings, splinting impression copings over and under the open tray. The accuracy of the transfer of the dental implants position was estimated by the size of the gap that occurs when fitting a permanent restoration. The smallest gap, (0,241 ± 0,06) mm, was detected using an open tray with splinting impression copings under the tray. It provides the most accurate result of the transfer of the dental implants position installed in parallel in comparison with other methods of obtaining impressions.

Journal of Volgograd State Medical University. 2019;16(1):69-73
pages 69-73 views

THE VALUE OF THE TYPE OF ANIMAL LOCOMOTION DURING THE FORMATION OF THE SYSTEMIC ORGANIZATION OF THE SHOULDER BONES ON THE EXAMPLE OF ORYCOLAGUS CUNICULUS, L. 1873

Yashina I.N., Zatolokin M.A.

Abstract

In order to study the systemic organization of the shoulder bone by factor analysis separately for the groups of right and left humerus bones 40 skeletons of the rabbit were investigated. The study found that the humerus of the rabbit is adapted to the reception and transmission of weight loads, it is characterized by morphofunctional differentiation of epiphyses, which is manifested by a large number of correlations within the distal epiphysis. The distal epiphysis of the left humerus to a greater extent than the distal epiphysis of the right bone takes part in the translation of weight.

Journal of Volgograd State Medical University. 2019;16(1):74-78
pages 74-78 views

ANTIGLYCATION AND DPP-4 INGIBITION ACTIVITY OF NOVEL AZOLEAZINE-DERIVED COMPOUNDS

Sokolova E.V., Hohlacheva E.A., SHamshina D.D., Batychyok A.E., Radaev P.A., Prokof'eva N.A., Litvinov R.A., Babkov D.A., Savateev K.V., Fedotov V.V.

Abstract

As a result of in vitro screening studies to search for the possible antidiabetic activity of a number of azoloazine derivatives, it was found that the compounds are capable of moderate inhibition of dipeptidylpeptidase-4 (DPP-4), inhibiting the enzyme activity by an average of 60 % at a concentration of 100 цМ, which is inferior actions of the reference drug vildagliptin (more than 99 % of the suppression of the activity of DPP-4 at the same concentration). The compounds are also able to significantly slow down glycation of bovine serum albumin (BSA) (the series leader - compound 1c suppresses the glycation reaction of BSA by 74 % at a concentration of 1 mM, compared to 58 % inhibition for the reference compound aminoguanidine). It was not possible to establish the ability of compounds to bind (chelate) Cu2+ in the ascorbic acid autooxidation test, except for compound 1k (it slowed down the reaction by 49 % at a concentration of 40 цМ, which is comparable in activity to the reference drug pioglitazone and is slightly more active than lipoic acid). The restriction for establishing the copper-binding activity of other members of the series is due to the high light absorption at the working wavelength of 265 nm and is not a criterion for excluding chelating properties. The results allow us to conclude that the class of compounds is a promising basis for the further development of tools with anti-glycating activity based on the structures of the representatives of the series.

Journal of Volgograd State Medical University. 2019;16(1):79-82
pages 79-82 views

ANALYSIS OF HISTOMORPHOLOGICAL CHANGES OF THE CORNEA IN PATIENTS WITH MYOPIA IN PRIMARY AND LONG-TERM PERIODS OF USE ORTHOKERATOLOGY CORRECTION

Ezhova E.A., Fokin V.P., Balalin S.V.

Abstract

This paper presents the results of a 3-year study of the histomorphological picture of the cornea in patients with myopia using orthokeratologic lenses (OKL). During the observation, a number of morphometric changes of the cornea were revealed in the «stressful» (1 month), steady (1 year) and distant (3 years) periods of adaptation, indicating the need for continuous monitoring of the cornea. Stability of morphometric parameters of the cornea after 3 years of use of the OKL indicates sufficient safety of the use of orthokeratological correction in the long-term period.

Journal of Volgograd State Medical University. 2019;16(1):83-86
pages 83-86 views

CEREBRAL CIRCULATION OF RUSSIAN AND FOREIGN STUDENTS IN VARIOUS FORMS OF MENTAL ACTIVITY

Mandrikov V.B., Sevriukova G.A., Isupov I.B., Likhodeeva V.A.

Abstract

During the classroom, intermediate control of knowledge and during the exam studies of the dynamics of pulse blood filling of the brain, the tone of the resistive arteries and conditions of cerebral venous outflow of blood of students of higher educational institutions. The majority of persons showed negative changes in the tone of the resistive arteries of the brain and difficulty in venous outflow of blood during various forms of knowledge control. Changes in cerebral blood flow are most significant during the exam. In the period of exam develops situational tachycardia, sympathetic tone. This negatively affects the tone of the resistive arteries of the brain and venous blood flow. The development of situational sympathicotonia must be considered when follow-up surveys of students.

Journal of Volgograd State Medical University. 2019;16(1):87-90
pages 87-90 views

MORPHOFUNCTIONAL PROPERTIES OF THE RATS BLOOD CELLS IN THE DEVELOPMENT OF EXPERIMENTALLY INDUCED ESTROGEN-DEPENDENT OVARIAN TUMORS

Sladkova E.A., Skorkina M.Y., Zhernakova N.I., Dmitriev V.N., Zhernakov E.V.

Abstract

Using the model of the experimental hormone-dependent tumor of the ovaries of mature female rats, the morphofunctional properties of the blood constituents closely associated with neoplastic ovarian cells were studied. Using modern technologies of AFM scanning and confocal laser scanning microscopy, it is shown that the development of the tumor process in the body is accompanied by a decrease in viability and an increase in the number of dead lymphocytes. Functionally, the leading populations that respond to the development of the tumor process in the body are leukocytes, which are characterized by the reactions of spreading and smoothing out the microrelief of the surface. The development of the tumor process is accompanied by a change in the elasticity of blood cells, which allows early diagnosis of tumor transformations in various tissues and organs.

Journal of Volgograd State Medical University. 2019;16(1):91-95
pages 91-95 views

CYTOLOGICAL METHOD OF RESEARCH IN THE DIAGNOSIS AND TREATMENT OF LICHEN PLANUS OF THE ORAL MUCOSA

Poroisky S.B., Firsova I.V., Makedonova Y.A., Poroiskaya A.V., Fedotova Y.M.

Abstract

One of the common inflammatory and destructive diseases in gerontostomatology is lichen planus. The course of this pathology is long, persistent and chronic. Early methods of diagnosing the disease, timely pharmacotherapy are the key to success in the treatment of lichen planus. Cytological method of research refers to the methods by which you can quickly get the results and adjust the scheme of drug symptomatic treatment of erosive and ulcerative lesions in the oral cavity. It is based on the study of the structural features of cellular elements. In this work, we examined and treated 60 patients with erosive-ulcerative form. In 30 people, in addition to traditional treatment, Titol's applications with a 0,1 % betamethasone solution are included in the scheme of complex therapy; in the second half of the patients, applications of betamethasone, fixed using a mucoadhesive polymer film, are used. In the resulting scrapings under magnification of x400 and x1000, the evaluation of the stage of destruction of epithelial cells with the corresponding morphological characteristic was made. In both cases, a positive trend was noted, however, the cytological picture was different depending on the type of drug therapy.

Journal of Volgograd State Medical University. 2019;16(1):96-99
pages 96-99 views

ELECTRIC EFFICIENCY INDEPENDENT AND STIMULATED CONTRACTION OF ABDOMINAL MUSCLES UPPER BOUND OF THE INGUINAL INTERVAL

Paskalov Y.S., Botezatu A.A., Railianu R.I.

Abstract

The method of an electromyography has investigated electroefficiency caused by physical activity and electrostimulation of reduction of abdominal muscles of the upper bound of an inguinal interval at 95 (59,7 %) patients with inguinal hernias and at 64 (40,3 %) patients without hernias. The decrease of amplitude, frequency and area of electromyograms, received from the area of the destroyed hernia of the inguinal interval at self-reduction of abdominal muscles, by 14,6; 40,2 and 20,2 % in comparison with the contralateral party was found. The level of amplitude and frequency of electromyograms inguinal areas of patients without hernias was (739,75 ± 79,77) MV and (50,38 ± 7,62) s, which is 39,6 and 73,5 % higher than the identical indices of functional activity of the upper boundary muscles of the destroyed hernia of inguinal and 28,9 % and 55,7 % more contralateral of the inguinal hernia side. The area of electromyograms inguinal areas of patients without hernia was above the power of muscle contraction around the inguinal hernia defect by 61,3 %. Use of an electromyostimulation of abdominal muscles has allowed to improve results of an electromyography both at patients without hernias, and among patients with inguinal hernias that has allowed has specified a difference in amplitude of electromyograms between them for 41 %.

Journal of Volgograd State Medical University. 2019;16(1):100-105
pages 100-105 views

PROGRAMS OF PRICE INTEREST AND THE ATTENTION OF VISITORS OF NETWORKING PHARMACIES

Ganicheva L.M., Vyshemirskaya E.V.

Abstract

The article presents data on the price interest of visitors in the implementation of a set of programs to build adherence to the pharmacy. The analysis of the types of programs used in the network pharmacy organizations, the frequency of their use was conducted and using the questionnaire revealed the attitude of the visitors to them.

Journal of Volgograd State Medical University. 2019;16(1):106-108
pages 106-108 views

CLINICAL AND DIAGNOSTIC FEATURES OF CHILDREN WITH MIXED SPECIFIC DISORDERS OF PSYCHOLOGICAL DEVELOPMENT

Razinkova N.S., Glotova I.V., Yakovleva A.V., Fetisova A.S., Minenkova T.A., Matvienko E.V.

Abstract

The article is devoted to the features of anamnesis, clinic and data of electroencephalography and magnetic resonance imaging of the brain of children with mixed specific disorders of mental development. A clinical analysis of 95 children with a tempo delay of development and a diagnosis of mixed specific mental development disorders was performed. Comparative analysis of EEG parameters revealed a number of indicators (benign epileptiform discharges of childhood, delta waves, etc.), necessary for early diagnosis of mixed specific mental development disorders.

Journal of Volgograd State Medical University. 2019;16(1):109-111
pages 109-111 views

HYGIENIC PROBLEMS DURING THE OPERATION OF ENTERPRISES FOR THE PRODUCTION OF ENERGY-POWERFUL MATERIALS

Krylova N.V., Britanov N.G., Klauchek V.V., Sazonova N.G., Tobol'skaya-Pospelova M.M., Gerbovnik-Busova O.V.

Abstract

During the operation of enterprises for the production of energy-intensive materials, hazardous chemicals can be released into the production and environment, where they can have a negative impact on the health of the personnel of the enterprise and residents of nearby communities. Nitroglycerin, ammonium perchlorate, aluminum and trinitrotoluene make the most significant contribution to the pollution of the working environment. In the atmospheric air of the territory adjacent to the object under study, in different years, excess of the maximum single concentrations of ammonium perchlorate and aluminum oxide were recorded.

Journal of Volgograd State Medical University. 2019;16(1):112-115
pages 112-115 views

BIOELECTRICAL ACTIVITY OF THE BRAIN IN OPERATORS WITH DIFFERENT CHRONOTYPES

Kudrin R.A., Lifanova E.V., Plotnikova A.V.

Abstract

The revealed features of the bioelectrical activity of the brain characterize the morning chronotype as the most preferable for operators. In a calm wakefulness state the representatives of this group have signs of intense attention (predominance of theta-rhythm), as well as increased mental activity on the background of emotional excitement (predominance of low-frequency beta-rhythm).

Journal of Volgograd State Medical University. 2019;16(1):116-119
pages 116-119 views

NEURORECEPTOROLOGICAL EFFECTS OF ANTIMIGRAINE AGENT 9-DIETHYL-2- (4-METHOXYPHENYL)IMIDAZO[1,2-A] BENZIMIDAZOL

Agatsarskaya Y.V., Yakovlev D.S., Maltsev D.S., Semenova Y.V., Salikhov D.A., Sultanova K.T., Anisimova V.A.

Abstract

The 5-НТ2А antagonistic, M-cholinergic, histaminergic and GABA-ergic properties of 9-diethylaminoethyl-2-(4-methoxyphenyl) imidazo [1,2-α] benzimidazole dihydrochloride - RU-31 compounds with antimigraine properties were studied. Moderate M-anticholinergic and GABA mimetic action and no effect on histaminergic system were shown for RU-31 compound in vivo models in vitro.

Journal of Volgograd State Medical University. 2019;16(1):120-124
pages 120-124 views

AGE AND GENDER PECULIARITIES OF HEART RATE VARIABILITY IN HEALTHY ADOLESCENTS

Sheveleva A.M.

Abstract

Introduction. The aim of the study was to find out gender and age peculiarities of the circadian rhythm of heart rate variability in healthy adolescents. Materials and methods: holter-ECG (spectral and temporal parameters of heart rate variability). 354 healthy adolescents were recruited to participate in this study. Results: adolescent girls have higher impact of parasympathetic nervous system to the heart rate modulation in comparison with boys. Relative power of the high-frequency band increased at night in girls and didn't significantly change in boys. Relative power of the low-frequency band decreased at night both in girls and in boys. Conclusion. The activity of divisions of autonomic nervous system in adolescents has circadian profile and differ in children of different sex and age.

Journal of Volgograd State Medical University. 2019;16(1):125-127
pages 125-127 views

AUTOMATED SYSTEM FOR TOPICAL DIAGNOSTICS IN CLINICAL NEUROLOGY

Filatov B.N., Vasiltchenko O.V., Chvorostova T.A., Shapochkina V.Y., Shcherbakov P.V., Antonov V.A.

Abstract

The ability to determine the localization of nervous system disorders plays a central role in neurological diagnosis. Undoubtedly, the introduction of computer tomography and magnetic resonance imaging into medical practice was the significant advance in clinical diagnostics. However, neurovisualization often requires reinforcement with a description of disease clinical manifestations. The article describes the possibilities of the program developed by the authors for recognizing the most probable localization of the nervous system affected area and evaluating the available symptoms and signs in the chance theory terms of specific disease presence.

Journal of Volgograd State Medical University. 2019;16(1):128-133
pages 128-133 views

LEFT HEART CHAMBERS REMODELING IN PATIENTS WITH RHEUMATOID ARTHRITIS WITH METABOLIC SYNDROME

Lisitsina Y.I., Shilova L.N., Alexsandrov A.V.

Abstract

The study included 87 patients with a reliable diagnosis of rheumatoid arthritis (RA), who were divided into two groups based on the presence of criteria for metabolic syndrome (MS). The parameters of lipid profile, morphometric, functional parameters of the left heart, signs of atherosclerosis of the aorta by Echocardiography were studied. Ms components were found in 53 people (60,9 %). The thickness of the interventricular septum, the posterior wall of the left ventricle (LV), LV myocardial mass index, indices of the time of early diastolic filling blood flow slowdown, LV isovolumetric relaxation time in patients with RA and RA and MS combination were higher than in the control group. Average values of end-systolic, end-diastolic sizes, LV ejection fractions were within normal limits. Almost all patients with MS showed signs of atherosclerosis of the aorta, a higher rate of atherogenicity, a tendency to form a concentric type of remodeling of the left heart, as well as diastolic dysfunction by hypertrophic type.

Journal of Volgograd State Medical University. 2019;16(1):134-136
pages 134-136 views

PROGRAMMED COORDINATED WORK OF THE CHEWING MUSCLES AND THE LOWER JAW'S POSITION IN THE TREATMENT OF PATIENTS WITH THE FUNCTIONAL PATHOLOGY OF THE TEMPOROMANDIBULAR JOINT

Klimova T.N., Timacheva T.B., Stepanov V.A.

Abstract

One of the most current problems of modern dentistry is the functional pathology of the temporomandibular joint (TMJ), caused by a malfunction of the masticatory muscles. Most clinicians agree on the need for programmed coordination of the work of the masticatory muscles and the relative position of the TMJ elements in order to determine the «true» central ratio which will be the starting point for the design of therapeutic occlusal splints. As part of the study, the possibilities of deprogrammatization techniques used in the diagnosis and treatment of functional pathology of TMJ were studied.

Journal of Volgograd State Medical University. 2019;16(1):137-140
pages 137-140 views

Pravila dlya avtorov

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Journal of Volgograd State Medical University. 2019;16(1):144-144
pages 144-144 views

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