Vol 13, No 1 (2016)
- Year: 2016
- Articles: 33
- URL: https://journals.eco-vector.com/1994-9480/issue/view/6054
Articles
PERSONALIZED MEDICINE: EVOLUTION OF METHODOLOGYAND THE PROBLEMS OF PRACTICAL IMPLEMENTATION
Abstract
Current aspects of personalized medicine were explored. An increasing role of applied biomedical technologies in studying specific biomarkers as part-an-parcel of the personalized approach was highlighted. The major obstacles for the introduction of the personalized approach into clinical practice as well as the ways of overcoming them were identified.
Journal of Volgograd State Medical University. 2016;13(1):3-11



THERAPEUTIC POTENTIAL OF CROSSLINK BREAKERS
Abstract
Non-enzymatic glycation of proteins is involved in the development of diabetes complications (angiopathy, cataract, ratinopathy nephropathy etc.), Alzheimer's disease (glycated formation of neurotoxic р-amyloid) and cancer. This process is also involved in the physiological aging of the body To date, the development of drugs that contribute to the restoration of the structure and functions of structural proteins remains a pressing issue.
Journal of Volgograd State Medical University. 2016;13(1):12-15



DERINAT IN TUBERCULOSIS. ANALYSI OF CLINICAL USE
Abstract
The review considers the pressing issues of modern phthisiology the ways of improving the effectiveness of treatment, the specific features of immunity in tuberculosis. It also summarizes the clinical use of Derinat, the reparative and immunomodulating drug.
Journal of Volgograd State Medical University. 2016;13(1):16-21



ANALYSIS OF THE STRUCTURE OF THE NOMENCLATURE OF CHILDREN'S MEDICINES REGISTERED IN THE RUSSIAN FEDERATION
Abstract
We carried out the analysis of the structure of the nomenclature of children's medicines registered in the Russian Federation, taking into account the sources they were obtained from, form of presentation, manufacturing countries and their pharmacological groups.
Journal of Volgograd State Medical University. 2016;13(1):22-24



INFLUENCE OF THE PREPARATION AFOBAZOLE ON THE CONDITION OF PREGNANT FEMALES RATSAND DEVELOPMENT OF POSTERITY IN ONTOGENESIS
Abstract
The experiments on pregnant female rats demonstrated that peroral administration of afobazole in a dose of 100 mg/kg from the 6th to the 20th days of pregnancy does not have a negative effect on the psycho-emotional condition of female rats during the periods of pregnancy and lactation. Moreover, the values of the dynamics of weight gain, the rate of muscular force maturation and motor behavior in rat pups were lower than the control ones. In the pups rats receiving Vdefinitive nutrition, the weight gain and behavioural activity did not differ from the control indicators, while the terms of sexual development were later in female rats and did not change in male rats. By the age of two months, the physical development of rat pups was completed and complied with the physiological standards.
Journal of Volgograd State Medical University. 2016;13(1):25-29



OPTIMIZATION OF METHOD IN VITRO FOR RE-GLYCATION ACTIVITY OF COMPOUNDS INVESTIGATION
Abstract
We reproduced an experimental model of studying in vitro re-glycation activity of compounds. The reliability of this method was confirmed be means of the tests employing alagebrium, a well-known advanced glycation end products (AGEs) breaker, in concentrations from 7 to 1,25 mM. The half-maximal inhibitory concentration (IC50) of this substance was calculated.
Journal of Volgograd State Medical University. 2016;13(1):30-32



ANTIBIOTIC RESISTANCE OF PURULENT-SEPTIC AGENTS IN SURGICAL DEPARTMENTS OF VOLGOGRAD HOSPITALS IN 2014
Abstract
A descriptive retrospective cross sectional study was conducted from January 2014 through January 2015. It involved 1005 patients with purulent-septic infections in six surgical departments of Volgograd hospitals. The prevalence of Methicillin-resistant S. aureus (MRSA) was 6,1 % of cases, Methicillin-resistant S. еpidermalis (MRSE) - 27,8 %, Vancomycin-resistant Enterococcus spp. (VRE) - 0,7 %, extended spectrum beta lactamase ESBL-producing Enterobacteriaceae - 11,6%.
Journal of Volgograd State Medical University. 2016;13(1):33-38



A SIMPLE METHOD OF SEARCHING FOR COMPOUNDS WITH GABAв-MIMETICACTION
Abstract
The paper proposes a new method of searching for substances with GABAb-mimetic action using the isolated uterus horn. We studied the effect of baclofen on changing extracellular concentration of K+ and Ca2+ in a variety of physiological solutions.
Journal of Volgograd State Medical University. 2016;13(1):39-42



SITUATION ANALYSIS AS A METHOD OF MAKING STRATEGICAL DECISIONS FOR SMALL PHARMACEUTICAL ENTERPRISES
Abstract
We demonstrated the application of SWOT, STEP and SPACE-analyses for evaluating the internal and external environment of an enterprise. The technologies of these methods are replicable and can be included in the methodological support of an automated workplace of an enterprise marketing specialist. Strategic ways of strengthening the position of a manufacturing enterprise at the modern market were described.
Journal of Volgograd State Medical University. 2016;13(1):43-47



THE INFLUENCE OF NOVEL GPR119 RECEPTOR AGONIST ZB-16 ON HEMOSTASIS IN DIABETIC RATS
Abstract
The paper showed the effect of GPR119 agonist on the glycemic level in experimental diabetes and coagulation hemostasis. We evaluated the plasma (coagulation) hemostasis in experimental animals with type 2 diabetes. After 4-week oral administration of ZB-16 the animals showed a significant decrease in blood glucose as compared to the controls and improved coagulation hemostasis: normalized APTT, prothrombin and thrombin time and fibrinogen.
Journal of Volgograd State Medical University. 2016;13(1):48-51



APPLICATION OF THE METHOD OF GC/MS DETECTION OF CLOZAPINE AND OLANZAPINE IN THE PHYSICAL EVIDENCE
Abstract
We developed a method of instant diagnosis of poisoning with clozapine and olanzapine using GC/MS. We defined retention times, mass spectral characteristics of the studied substances, which makes it possible to reliably identify them in the physical evidence.
Journal of Volgograd State Medical University. 2016;13(1):52-55



ANTITHROMBOTIC ACTIVITY OF DAB-15 USING A MODEL OF ELECTRICALLY-INDUCED THROMBOSIS
Abstract
Antithrombotic action of the novel diazepine benzimidazole derivative agent DAB-15 having antiaggregatory activity was investigated in comparison to the antiaggregant drugs (acetylsalicylic acid, ticlopidine and clopidogrel) using the electrically-induced thrombosis model in rats. DAB-15 and the compared antiaggregant drugs of acetylsalicylic acid, ticlopidine and clopidogrel demostrated dose-dependent antithrombotic activity. The effect of DAB-exceeded those of acetylsalicylic acid and ticlopidine, but was inferior compared to the activity of clopidogrel.
Journal of Volgograd State Medical University. 2016;13(1):56-58



COMPARATIVE BIOINFORMATIC ANALYSIS OF PRIMARYAMINO ACID SEQUENCES OFANGIOTENSIN II RECEPTOR TYPE 1 OF HUMANSAND VARIOUS ANIMALS
Abstract
In the current study the bioinformatic comparison of primary amino acid sequences of angiotensin II receptor type 1 (AGTR1) of humans and various animals was performed. We showed that the amino acid sequence of rabbit AGTR1 is most similar to that of humans.
Journal of Volgograd State Medical University. 2016;13(1):59-61






ANALYSIS OF THE INDICES OF CAPILLARY BLOOD FLOW IN PATIENTS WITH LICHEN PLANUS OF THE ORAL MUCOSA
Abstract
The issues of pathogenetic diagnosis of diseases of the oral mucosa remain most complicated and pressing for dentists. The role of capillary blood flow disorders in the pathogenesis of inflammatory - destructive diseases of the oral cavity is quite significant. In this paper we studied the features of microcirculation in healthy subjects and patients with lichen planus both at the site of the lesion and on the symmetrical side using laser Doppler flowmetry. LDF showed decreased indicators of microcirculation both on the affected and the clinically unchanged symmetrical side. Indicators of LDFgrams in healthy subjects differed significantly from patients with erosive and ulcerative lesions in the oral cavity.
Journal of Volgograd State Medical University. 2016;13(1):65-67






CEREBRAL HEMODYNAMIC CHANGES IN ADOLESCENTS WITH CERVICAL OSTEOCHONDROSIS
Abstract
The study revealed hemodynamic changes in adolescents with cervical osteochondrosis. The hemodynamic changes occurred both at rest and during functional tests which involved turning the head to one side. The most sensitive indicators of changes were those associated with the vascular tone.
Journal of Volgograd State Medical University. 2016;13(1):75-77



CLINICAL VALUE OF INSULIN RESISTANCE IN PATIENTS WITH CHRONIC HEART FAILURE AND DIABETES MELLITUS TYPE 2
Abstract
An ever-increasing prevalence of heart failure has led to the search for more significant risk factors for the development and progression of heart failure. It has recently been demonstrated that insulin resistance plays an important role in the pathogenesis and progression of heart failure. The study of the clinical value of insulin resistance in patients with heart failure and diabetes type 2 seems to be promising.
Journal of Volgograd State Medical University. 2016;13(1):78-82



RENAL FUNCTION AND ADDITIONAL DRUGTHERAPY IN PATIENTS WITH CHRONIC HEART FAILURE AND DIABETIC CARDIAC AUTONOMI NEUROPATHY
Abstract
The article assesses renal dysfunction in patients with chronic heart failure and diabetes type 2 accompanied by cardiac autonomic neuropathy. Combined therapy with meldonium, which exhibits renal protective properties, is considered a potential treatment for chronic heart failure.
Journal of Volgograd State Medical University. 2016;13(1):83-87



CONTRIBUTION OF GELATINASE В TO THE PATHOGENESIS OF EXPERIMENTALLY-INDUCED CHRONIC INFLAMMATION OF THE ENDOMETRIUM
Abstract
The article discusses the role of gelatinase B positive cell expression in the pathogenesis of experimentally-induced chronic inflammation of the endometrium. The study of white female Wistar rats with experimentally-induced endometrial inflammation showed a reduction in the specific number and intensity of gelatinase B positive cell expression in the glandular epithelium and, to a larger extent, in the cellular stroma. Gelatinase B has been reported to play a role in chronization of inflammation.
Journal of Volgograd State Medical University. 2016;13(1):88-90






COMPARATIVE EVALUATION OF THE QUALITY OF LIFE IN PATIENTS WITH DISEASES OF THE EYE AND OCULAR ADNEXA
Abstract
We evaluated and compared the quality of life of 688 patients with diseases of the eye and ocular adnexa. To evaluate the quality of life, we used a SF36 questionnaire. We compared the results obtained in the study with the reference population values.
Journal of Volgograd State Medical University. 2016;13(1):94-96



AGE-RELATED CHANGES IN CERTAIN STRUCTURAL PARAMETERS OF THE LEFT VENTRICLE
Abstract
An estimated 180 individuals from various age groups (from adolescents to elderly) without any heart disease underwent echocardiography We identified age-related structural changes in the left ventricle which are manifested by hypertrophy of its posterior wall and interventricular septum, reaching the maximum values after 75 years. The data obtained can be used as age-specific normal values for the left ventricle.
Journal of Volgograd State Medical University. 2016;13(1):97-99



DEVELOPMENT AND INVESTIGATION OF GEL COMPOSITIONS WITH CYCVALON IN COMPLEX TREATMENT OF BACTERIAL VAGINOSIS
Abstract
The study showed the efficacy of gel compositions with cycvalon in the treatment of bacterial vaginosis. The use of cycvalonum-K1, a hydrophilic gel, helps reduce the time of the second systemic treatment for bacterial vaginosis.
Journal of Volgograd State Medical University. 2016;13(1):100-102



CHARACTERISTICS OF ALEXITHYMIA IN HEALTH PROFESSIONALS
Abstract
We used the Toronto Alexithymia Scale to study alexithymia level in health professionals. The study has shown that the respondents have cognitive and affective disorders. A range of psychological treatment techniques and drug therapy have been recommended for health professionals with alexithymia.
Journal of Volgograd State Medical University. 2016;13(1):103-104



EFFECTIVENESS OF PRP-THERAPY IN THE TREATMENT OF EROSIVE ULCERATIVE ORAL LICHEN PLANUS
Abstract
Platelet-rich autoplasma, which is currently used in clinical medicine, holds potential as a useful treatment strategy in dental practice. Its use in the treatment of oral diseases, especially those affecting the oral mucosa, as an anti-inflammatory and reparative agent has been shown to be beneficial. The article reviews the results of examination and treatment of patients with oral lichen planus. The patients were divided into two groups based on prescribed therapy (1st group received conventional therapy, 2nd group received platelet-rich autoplasma). Clinical and cytological findings have shown that autohaemotherapy is superior to the conventional method in treating erosive and ulcerative oral lesions, thus proving the feasibility of this technique in the practice of therapeutic dentistry.
Journal of Volgograd State Medical University. 2016;13(1):105-108



DISTINCTIVE FEATURES IN THE STRUCTURE OF THE PERIPHERAL NERVES OF THE FLEXORS IN THE MIDDLE THIRD SHOULDER OF CLOVEN-HOOFED MAMMALS
Abstract
The article reviews a comprehensive study of the microstructure of the peripheral nerves of the brachial plexus which innervates flexor muscles in the middle third of the shoulder. We identified significant differences in the morphological structure of the nerve bundles, neural membranes, including paraneural connective tissue, in animals with a various degree of motor activity of the thoracic limb. There is morphological evidence of bilateral asymmetry, and we identified the functional role of paraneural fascial cellular space.
Journal of Volgograd State Medical University. 2016;13(1):109-115



COMPARATIVE EPIDEMIOLOGICAL STUDY OF PRIMARY DISABILITY IN CHILDREN IN THE RUSSIAN FEDERATION, SOUTHERN FEDERAL DISTRICT AND THE VOLGOGRAD REGION
Abstract
We studied the dynamics of primary disability in children in the Volgograd region between 2012-2014. We compared the values of primary disability in children in the Volgograd region with the values in the Russian Federation and the Southern Federal District.
Journal of Volgograd State Medical University. 2016;13(1):116-120



SELECTING THE MOST APPROPRIATE METHOD OF FORMING PANCREATODIGESTIVE ANASTOMOSIS AFTER RADICAL PANCREATIC HEAD CANCER SURGERY
Abstract
The article presents a comparative analysis of pancreatoduodenectomy outcomes in patients who received reconstruction with either pancreaticojejunostomy or pancreaticogastrostomy, although postoperative results remained unsatisfactory (the pancreatic tissue was soft, the main pancreatic duct was narrowed). The comparison of the results of the reconstruction showed that the formation of a pancreatodigestive anastomosis seems to be the treatment of choice for patients with the soft pancreatic stump and the narrowed duct of Wirsung, thus reducing the number of specific complications and improving outcomes.
Journal of Volgograd State Medical University. 2016;13(1):121-125



THE RELATIONSHIP BETWEEN CERTAIN MORPHOLOGICAL AND FUNCTIONAL PARAMETERS OF THE HAND AND BODY MASS INDEX IN GIRLS AGED 16-21
Abstract
The article describes morphological and functional parameters of the hand and body mass index in girls aged 16- 21 years. The purpose of the study is to identify the relationship between body mass index and morphological and functional parameters of the hand in adolescent girls. The process has been conducted with the use of our own software. We found that the force of the hand correlated closely with the square of the palmar surface.
Journal of Volgograd State Medical University. 2016;13(1):126-128



EFFECTIVENESS OF BARIEDERM AND LOSTERIN IN THE EXTERNAL THERAPY OF PALMOPLANTAR KERATODERMA IN METALLURGICAL INDUSTRY WORKERS
Abstract
The article describes non-hormonal treatment and prevention of keratoderma exacerbations in the workers involved in ferrous metallurgy smelting. These workers tend to use oxidative melting of Al2O3, ZnO2 and SiO2-based refractory materials as well as solid (NaNO3, NH4NO3) and gaseous (oxygen, air) oxidizers.
Journal of Volgograd State Medical University. 2016;13(1):129-131



OPTIMIZATION OF SELECTING AN OPERATION METHOD IN RECTOVAGINAL FISTULAS
Abstract
We optimized the selection of surgical treatment methods in patients with rectovaginal fistulas by individual justification of the selected method and development of differential diagnosis and treatment algorithm. The use of the technique of radical excision of rectovaginal fistula, complemented with anterior sphincterolevatoroplasty is the most promising way to significantly reduce the number of postoperative complications and recurrence of the disease by restoring the layered structure of the rectovaginal septum, to decrease the duration of pain and promote the restoration of the closing function of the rectum.
Journal of Volgograd State Medical University. 2016;13(1):132-135



ANALYSIS OF THE USE OF OPIOID ANALGESICS FOR MEDICAL PURPOSES IN THE VOLGOGRAD REGION
Abstract
The article assessed the environmental availability of opioid analgesics for medical purposes in the Volgograd region. We presented the results of studies of the effect of changes in regulatory documents related to narcotic drugs and psychotropic substances on the availability of drugs of this group for the patients who need them.
Journal of Volgograd State Medical University. 2016;13(1):136-139


