Vol 13, No 1 (2016)

Non-enzymatic glycation of proteins is involved in the development of diabetes complications (angiopathy, cataract, ratinopathy nephropathy etc.), Alzheimer's disease (glycated formation of neurotoxic р-amyloid) and cancer. This process is also involved in the physiological aging of the body To date, the development of drugs that contribute to the restoration of the structure and functions of structural proteins remains a pressing issue.

We carried out the analysis of the structure of the nomenclature of children's medicines registered in the Russian Federation, taking into account the sources they were obtained from, form of presentation, manufacturing countries and their pharmacological groups.

We reproduced an experimental model of studying in vitro re-glycation activity of compounds. The reliability of this method was confirmed be means of the tests employing alagebrium, a well-known advanced glycation end products (AGEs) breaker, in concentrations from 7 to 1,25 mM. The half-maximal inhibitory concentration (IC50) of this substance was calculated.

The paper proposes a new method of searching for substances with GABAb-mimetic action using the isolated uterus horn. We studied the effect of baclofen on changing extracellular concentration of K+ and Ca2+ in a variety of physiological solutions.

The paper showed the effect of GPR119 agonist on the glycemic level in experimental diabetes and coagulation hemostasis. We evaluated the plasma (coagulation) hemostasis in experimental animals with type 2 diabetes. After 4-week oral administration of ZB-16 the animals showed a significant decrease in blood glucose as compared to the controls and improved coagulation hemostasis: normalized APTT, prothrombin and thrombin time and fibrinogen.

Antithrombotic action of the novel diazepine benzimidazole derivative agent DAB-15 having antiaggregatory activity was investigated in comparison to the antiaggregant drugs (acetylsalicylic acid, ticlopidine and clopidogrel) using the electrically-induced thrombosis model in rats. DAB-15 and the compared antiaggregant drugs of acetylsalicylic acid, ticlopidine and clopidogrel demostrated dose-dependent antithrombotic activity. The effect of DAB-exceeded those of acetylsalicylic acid and ticlopidine, but was inferior compared to the activity of clopidogrel.

A case report of endoscopically assisted minimally invasive surgery for Bouveret syndrome, performed in 2001, was provided in this article. The review analyzed the features of treatment of Bouveret syndrome.

The article presents a comprehensive evaluation of the shoulder joint and treatment outcomes in patients with recurrent anterior shoulder dislocation following Bristow-Latarjet surgery.

An ever-increasing prevalence of heart failure has led to the search for more significant risk factors for the development and progression of heart failure. It has recently been demonstrated that insulin resistance plays an important role in the pathogenesis and progression of heart failure. The study of the clinical value of insulin resistance in patients with heart failure and diabetes type 2 seems to be promising.

The article discusses the role of gelatinase B positive cell expression in the pathogenesis of experimentally-induced chronic inflammation of the endometrium. The study of white female Wistar rats with experimentally-induced endometrial inflammation showed a reduction in the specific number and intensity of gelatinase B positive cell expression in the glandular epithelium and, to a larger extent, in the cellular stroma. Gelatinase B has been reported to play a role in chronization of inflammation.

We evaluated and compared the quality of life of 688 patients with diseases of the eye and ocular adnexa. To evaluate the quality of life, we used a SF36 questionnaire. We compared the results obtained in the study with the reference population values.

The study showed the efficacy of gel compositions with cycvalon in the treatment of bacterial vaginosis. The use of cycvalonum-K1, a hydrophilic gel, helps reduce the time of the second systemic treatment for bacterial vaginosis.

Platelet-rich autoplasma, which is currently used in clinical medicine, holds potential as a useful treatment strategy in dental practice. Its use in the treatment of oral diseases, especially those affecting the oral mucosa, as an anti-inflammatory and reparative agent has been shown to be beneficial. The article reviews the results of examination and treatment of patients with oral lichen planus. The patients were divided into two groups based on prescribed therapy (1st group received conventional therapy, 2nd group received platelet-rich autoplasma). Clinical and cytological findings have shown that autohaemotherapy is superior to the conventional method in treating erosive and ulcerative oral lesions, thus proving the feasibility of this technique in the practice of therapeutic dentistry.

We studied the dynamics of primary disability in children in the Volgograd region between 2012-2014. We compared the values of primary disability in children in the Volgograd region with the values in the Russian Federation and the Southern Federal District.

The article describes morphological and functional parameters of the hand and body mass index in girls aged 16- 21 years. The purpose of the study is to identify the relationship between body mass index and morphological and functional parameters of the hand in adolescent girls. The process has been conducted with the use of our own software. We found that the force of the hand correlated closely with the square of the palmar surface.

We optimized the selection of surgical treatment methods in patients with rectovaginal fistulas by individual justification of the selected method and development of differential diagnosis and treatment algorithm. The use of the technique of radical excision of rectovaginal fistula, complemented with anterior sphincterolevatoroplasty is the most promising way to significantly reduce the number of postoperative complications and recurrence of the disease by restoring the layered structure of the rectovaginal septum, to decrease the duration of pain and promote the restoration of the closing function of the rectum.