Vol 50, No 1 (2001)


Preeclampsia and pathology of placentation

Erkkola R.


Etiology of pre-eclampsiaremainsunclear. However, it is recognized that genetic factors of both mother’s and father’s sides can determine the development of this awesome complication of pregnancy. The interplay of genetic factors with external influences determines the risk level of pre-eclampsia. Today it is reasonable to assert that pre-eclampsia is a complication of pregnancy associated with the disturbances of the process of trophoblast invasion and changes in haemodynamics in spiral arteries. The process of trophoblast invasion proved to be coordinated by combined interaction of cytokines, factors of adhesion and different growth factors.
Functional abnormalities of endothelium of placental and pre-placental vessels may be a result but not a cause of development ofpre-eclampsia, pathophysiology of which is studied still insufficiently. However, the disturbance оf NO, endothelein release and thrombocytes homeostasis as well are certain to be the main manifestations of this pregnancy complication. A fter revealing all the mechanisms of process of trophoblast invasion disturbances an actual possibility of early prevention and treatment of pre-eclampsia may be elaborated.

Journal of obstetrics and women's diseases. 2001;50(1):87-93
pages 87-93 views

Original Research

Betadin (EGIS) in treatment of inflammatory diseases and dysbiotic state of external female genital organs

Popova S.S.


The special research of clinicalproperties of Betadin EGIS showed its efficiency in 85% cases. The analysis of the data made it possible to conclude that for today Betadin EGIS is a preferable preparation in treating vulvo-vaginitis and other pathological states andprocesses in externalfemale genital organs. The main advantage of the preparation is its wide spectrum of action. It enables to begin adequate and effective therapy in due time without waiting for the results offinal bacteriological diagnostics. The research showed that Betadin EGIS has high tolerance, if necessary it can be used in combination with others antibacteriological drugs.

Journal of obstetrics and women's diseases. 2001;50(1):61-63
pages 61-63 views

The peculiarities of osteal system maturation in patients w ith primary estrogenic deficit

Uvarova E.V., Volobuev A.I., Rudneva T.V., Rudnev S.V.


In patients with congenital ovarian insufficiency, particularly with gonadal dysgenesis, the retarded bone remodelingprevents the bone tissue from achieving its final, peak density and leads to the lagging of skeletal system maturation. This may result in high risk of limb and backbone fractures.
The article analyzes the results of the examination of 142 patients with different forms of gonadal dysgenesis. The treatment included the preparations containing estrogens, which were identical with natural ones (Divina, Divitren, Divigel). The data received substantiate the necessity of eliminating the estrogenic deficit in patients with gonadal dysgenesis earlier than it is usually done.

Journal of obstetrics and women's diseases. 2001;50(1):64-68
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Laparoscopy in diagnosis and complex treatm ent of malignant ovarian tumors

Tsypurdeeva A.A., Urmancheeva A.F., Zeldovich D.R., Kira E.F.


To study the possibilities of laparoscopy in diagnosis of malignant ovarian tumors 635 patients at different stages of the disease were examined. High informing characteristics make it possible to recommend laparoscopy as a method of improved diagnostics of tumors in smallpelvic with the aim of early revealingof malignant tumors, morphologic verification and evaluation of tumor extensiveness, diagnosis of preclinical recurrent tumors in case of diverse results of non-invasive monitoring methods.

Journal of obstetrics and women's diseases. 2001;50(1):69-73
pages 69-73 views

The state of hemostasis in perimenopause and hormonal replacement therapy

Repin M.A.


The interruption in the ovarianfunctioning goes along with the disturbances of vascular-trombocyte hemostasis: intravascular trombocyte activation increases, trombocyte micro- and macro-aggregates appear. Cyclic hormonal replacement therapy with Femoston, which contains estradiol and didrogesterone, helps to normalize the trombocytogram. Besides that, the addition of progestagen didrogesterone increases the effect of estradiol on micro circular hemostasia.

Journal of obstetrics and women's diseases. 2001;50(1):74-79
pages 74-79 views


On the 115th anniversary of the establishment of the St. Petersburg Obstetric and Gynecological Society

Tsvelev Y.V.


On January 18, 1886, a preparatory meeting headed by professors A.Ya. Krassovsky and K.F. Slavyansky on the organization of the first society of obstetricians and gynecologists a kind of Scientific Center in Russia.

Journal of obstetrics and women's diseases. 2001;50(1):1-1
pages 1-1 views

Scientific activity

Plenum of the Interdepartmental Scientific Council on Obstetrics and Gynecology of the Russian Academy of Medical Sciences M3 RF "Oncological screening, carcinogenesis and early stages of cancer in the practice of a gynecologist"

Tokhiyan A.A.


October 31 - November 1, 2000 in Izhevsk the Plenum of the Interdepartmental Scientific Council on Obstetrics and Gynecology of the Russian Academy of Medical Sciences M3 of the Russian Federation was held. Despite the allocation of two different specialties in clinical medicine - gynecology and gynecological oncology, the problems of risk and early diagnosis of gynecological cancer occupy a prominent place in the activities of an obstetrician-gynecologist. Diseases of the breast are of no less importance for clinical practice. The topic of this Plenum is a logical continuation of previous discussions on topical issues of modern gynecology - "Ways of development of modern gynecology" and "Ovarian tumors", held within the framework of the Ministry of Taxes and Communications.

Journal of obstetrics and women's diseases. 2001;50(1):7-7
pages 7-7 views

Resolution of the plenum of the interdepartmental scientific council on obstetrics and gynecology, RAMS M3 RF

Board E.


Over the past 10 years in Russia, there has been an intensive increase in the incidence of malignant tumors of the reproductive system in women, whose share in the structure of oncological diseases amounted to 36.9%. The current situation is primarily due to an increase in the incidence of malignant tumors of the mammary gland, endometrium, and ovaries. The incidence of breast cancer is growing at a particularly fast pace. Over the past decade, the indicators have increased by more than 70%. The emerging trend towards a decrease in the incidence of cervical cancer in the 70-80s was replaced by a new rise in the period 1990-1999, mainly due to the II-III stages of the disease. The main peak of incidence corresponds to the age period of 56-65 years with a tendency to "rejuvenate" breast cancer up to 35-50 years.

Journal of obstetrics and women's diseases. 2001;50(1):8-8
pages 8-8 views

Problems of malignant tumors of reproductive system in gynecological practice

Kulakov V.I., Tochijan A.A.


In the article the problems of epidemiology, prophylaxis and detection of early stages of malignant tumors of reproductive system and mammae in gynecological practice in close contact with oncologists are discussed.

Journal of obstetrics and women's diseases. 2001;50(1):9-12
pages 9-12 views

On the model of hormonal carcinogenesis on the example of uterine leiomyoma: problems and prospects

Vikhlyaeva E.M.


The main principles of progesterone hypothesis and the role of auto- and paracrine factors in uterine leiomyoma pathobiology are considered in the article. The necessity of early therapeutic intervention since humor detection is maintained with the aim of reproductive health recovery. The basic features of strategy in case of uterine leiomyoma are defined: measures due to be undertaken since humor detection, determination of limits and possibilities of adjuvant medicamental treatment and optimal time for surgery, conducting patients in peri- and postmenopause and evaluation of oncological risk.

Journal of obstetrics and women's diseases. 2001;50(1):13-17
pages 13-17 views

Hormonal rehabilitation of patients with cervical cancer after radical surgical treatment

Urmancheeva A.F., Bernstein L.M., Бурмина М.M., Zeldovich D.R., Gamayunova V.B., Kovalenko I.G.


Radical surgical treatment with and without radiation often induces symptoms of premature menopause in cervical cancer (CC) patients. Few retrospective studies seem to suggest that hormonal replacement therapy (HRT) is not detrimental for patients with CC and can improve life quality in this group of women. To investigate the effect of HRT on menopausal symptoms inpatients with С C history, 85 patients after CC treatment, 22-51 years old, were included into this research. In 59 patients HRT was carried out to overcomepostovariectomic syndrome (POES). Severity of menopausal symptoms, serum estradiol, FSH and lipid profiles were evaluated. The research showed high therapeutic effect as to reducing the frequency of postovariectomic frustration in HRT application. No recurrences of CC were observed in this group of patients. HRT side effects were extremely rare. HRT can effectively cure climacteric symptoms in women with surgical menopause induced by CC treatment.

Journal of obstetrics and women's diseases. 2001;50(1):18-22
pages 18-22 views

The use of modern minimally invasive technologies and imaging (CT) methods in the diagnosis and surgical treatment of endometrial hyperplastic processes and combined gynecological pathology

Adamyan L.V., Tkachenko E.R., Kiselev S.I., Gaidarova A.K.


On the basis of retrospective and prospective analysis of case reports of 540 patients with recurrent endometrial hyperplasia and combined intrauterine pathology (recurrent endometrial hyperplasia + hysteromyoma and/or adenomyosis) some aspects of surgical treatment of the pathology are considered, the effectiveness of different kinds of endoscopic operations is analyzed. Potentialities of spiral computerized tomography (SCT) for diagnosis of uterine disease are examined.


Journal of obstetrics and women's diseases. 2001;50(1):23-26
pages 23-26 views

Gynecological aspects in the trends in morbidity and mortality from cancer of the reproductive system

Ashrafyan L.A., Novikova E.G.


The article discusses the incidence rates of cancer of the reproductive system organs (mammary gland, endometrium, ovaries, cervix) in Moscow in 1999, analyzes the trend of these indicators over the past 10 years, substantiates the need to revise the principles of the primary care of the obstetric and gynecological service (female consultations), a model of a gynecological diagnostic center is proposed

Journal of obstetrics and women's diseases. 2001;50(1):27-33
pages 27-33 views

Proliferative activity of the epithelium in squamous epithelial lesions of the cervix

Manukhin I.B., Minkina G...


As a criterion for precancerous changes in the stratified squamous epithelium of the cervix, its proliferative activity, studied using monoclonal antibodies PC-10 to the antigen of proliferating cell nuclei (PCNA), is considered. The results of the studies showed that patients with a low degree of squamous intraepithelial lesion are characterized by weak proliferative activity, and for patients with a high degree of lesion it is moderate and pronounced. An increase in proliferative activity is a prognostic factor that determines long-term persistence and the likely progression of the lesion.

Journal of obstetrics and women's diseases. 2001;50(1):34-36
pages 34-36 views

Cytokine production by peripheral blood lymphocytes in patients with ovarian epithelial tumors

Pavlov R.V., Aksenenko V.A., Krivoruchko A.Y., Pavlenko N.A.


In presence of autoserum, production of IL1b, IL2, IL4, IL6 and TNFa by peripheral blood lymphocytes of 30 patients with epithelial tumors of ovaries and 50 patients with epithelial ovarian cancer of I-IV stages was investigated. The data received enable to ascertain the increase of mononuclear activity during ovarian tumor progression, increase of T-helpers of the second type activity, along with the reduction of T-helpers of the first type activity in peripheral blood of patients, and abnormalities of IL6-dependent mechanism of control of ILIb and TNFa production by peripheral blood lymphocytes of patients with ovarian cancer.

Journal of obstetrics and women's diseases. 2001;50(1):37-40
pages 37-40 views

Morbidity with malignant neoplasms of female genital organs in Amur region

Bystritskaya T.S., Merekina L.I., Dyubanova T.E., Maksimova A.B., Zaritskaya E.N., Lysyak D.S.


Morbidity with malignant neoplasms offemale genital organs in Amur region makes up 38-45per 100000 women. Cervical and uterine carcinomae dominate through all malignant tumors. The authors point to the low rate оfcase detecting as to women with genital neoplasms. Late diagnostics lead to unfavourable prognosis. General cancer mortality decreased for the last three years but still remains high. To reduce the rate of oncological diseases a regional programme including tumor and pretumor screening is to be elaborated.

Journal of obstetrics and women's diseases. 2001;50(1):41-42
pages 41-42 views

Specific immunotherapy in the complex treatment of ovarian cancer

Makarov O.V., Krotenko A.A., Kosetsky V.N., Sidorovich I.G., Novikov V.I., Vlasov A.A.


The article is devoted to the search for new solutions in the field of treatment of malignant ovarian tumors and, in particular, new approaches for overcoming immune resistance in a complex method of therapy. The experience of treating this pathology with an original method of postoperative immunotherapy using autologous immunomodulators, which, due to its simplicity and relatively low cost, should be widely used in gynecological oncology, is considered.

Journal of obstetrics and women's diseases. 2001;50(1):43-46
pages 43-46 views

Some features of the clinical course and treatment of cervical dysplasia depending on age

Kropaneva V.V., Kostyuchek D..., Maximov S.Y.


The article presents data on 231 cases of diagnosed cervical dysplasia in patients aged 21 to 80 years. The clinical course and biological behavior of the pathological process was studied depending on the severity and methods of treatment in patients in different age groups. A more aggressive course of the disease was noted in women under the age of 30.

Journal of obstetrics and women's diseases. 2001;50(1):47-49
pages 47-49 views

Risk factors for dyshormonal benign hyperplasia and breast cancer

Khurasev B.F., Gurkin Y.A.


Risk factors for the occurrence of benign diseases and breast cancer were studied in a comparative analysis of the survey data of 321 women who were operated on the mammary gland, had an established histological diagnosis and were registered in the oncology offices of the Kursk polyclinics (main group), and 150 women who did not have any clinical , no objective manifestations of breast pathology (comparison group). To study the frequency of dyshormonal hyperplasias of the mammary glands and risk factors in girls, an in-depth preventive examination of 390 schoolgirls aged 13-17 years was carried out.

Journal of obstetrics and women's diseases. 2001;50(1):50-54
pages 50-54 views

The role of echography in the diagnosis of diffuse fibroadenomatosis of the mammary glands

Solntseva I.A.


Traditional methods of examining the mammary glands do not provide a sufficiently high level of diagnostics of the pathology of this organ. It is necessary to use new techniques, including ultrasound research. Echography has ample opportunities in the diagnosis of various diseases of the mammary glands, and with diffuse fibroadenomatosis it is the preferred method. The author noted the main advantages of an ultrasound study, and also developed quantitative criteria that make it possible to more clearly diagnose pathology and determine the severity of the disease.

Journal of obstetrics and women's diseases. 2001;50(1):55-60
pages 55-60 views


Epidemiology and diagnosis of cervical cancer

Ourmantcheeva A.F., Merabishvili V.M., Selcov S.A., Novik V.I., Safronnikova N.R., Kutusheva G.F., Vorontsova A.E., Lisyanskaya A.S., Vedeneeva G.N., Golovanova V.A., Kutueva F.R., Zeldovich D.R., Manikhas G.M., Ailamazyan E.K.


The data of populational and hospital cancer registers, cytological and immunological laboratories of Saint-Petersburg are examined. More than 350 new invasive cervical cancer cases are registered annually. Since 1970 up to 1991 oncological morbidity decreased from 14,7 to 8,1 per 100000 women, but then we witness steady rise of standardized indeces up to 9,9 in 1999. Increasingrate of so called “neglectedforms” of cervical cancer (III-IV stages), especially amongyoung women, is a disturbing fact. The issues of prophylaxis and early diagnostics of cervical cancer are discussed in the article. The results of cytological and virological examination of women of different contingents are drawn.

Journal of obstetrics and women's diseases. 2001;50(1):80-86
pages 80-86 views

History page

For the 100 year anniversary of Prof. R.R. Makarov

Tsvelev J.V.


Roman Romanovich Makarov was born on June 12, 1901 in the village of Vitino in the Peterhof district of the Petersburg province, into a large peasant family, in which there were 9 other children besides him.

Journal of obstetrics and women's diseases. 2001;50(1):94-96
pages 94-96 views

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