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卷 28, 编号 4 (2020)
- 年: 2020
- ##issue.datePublished##: 15.12.2020
- 文章: 18
- URL: https://journals.eco-vector.com/pavlovj/issue/view/3305
- DOI: https://doi.org/10.23888/PAVLOVJ284
Original study
Parameters of macrophage reaction and humoral immunity in patients with implant-associated in-flammation after primary endoprosthetics of knee joint
摘要
Aim. To study peculiarities of macrophage reaction and humoral immunity in patients with signs of implant-associated inflammation after the primary endoprosthetics of the knee joint.
Materials and Methods. Examination of 48 patients with signs of implant-associated inflammation after the primary endoprosthetics of the knee joints (the main group) and of 44 patients without signs of inflammatory reactions (comparison group) was carried out. Control group involved 30 healthy donors without diseases of the musculoskeletal system.
Results. In 1 and 12 months after the surgery, patients of the main group showed elevated levels of the factor inhibiting migration of macrophages (MIF), of macrophage stimulating protein (MSP), class A immunoglobulins (IgA), С3 and С4 complement components as compared to control, and also to each previous period. In 1 month after the surgery, the content of class M and G immunoglobulins (IgM and IgG) decreased relative to control; in 12 months after the surgery a more pronounced reduction was noted. Increase in serum concentrations of MIF, MSP, IgA, С3 and С4-complement components was noted in the comparison group in 1 and 12 months and also in comparison with the previous period. Reduction of the levels of IgM, IgG in 1 and 12 months after the operation was noted in comparison with control and with the previous period.
Conclusion. A study of parameters of macrophage reaction, proteins of complement system and the main classes of immunoglobulins permits to identify signs of implant-associated inflammation in 1 and 12 months after surgery, and, consequently, to determine patients of risk groups that require additional diagnostics measures.
421-428
Modeling of fibrocystic mastopathy in experiment on animals
摘要
Nowadays, hormonal imbalance is proven to be a factor that influences initiation of malignant and benign breast tumors. To study the aspects of participation of sex hormones in damage to organs and tissues, it may be necessary to model a common women’s pathology – fibrocystic disease of mammary glands characterized by the most pronounced effects of this pathogenetic factor, on experimental animals.
Aim. To create a model of fibrocystic disease of mammary gland with the subsequent possibility of studying morphological manifestations of the disease in natural and drug-induced pathomorphism.
Materials and Methods. The pathology was induced by intramuscular injection of 0.5 ml of 2% synestrol and 0.5 ml of 2.5% progesterone to virgin female rats on the 1st, 7th, 14th, 21st, 28th and 35th days of the experiment. For examination, histological preparations of inguinal mammary glands were made. The preparations were described and studied using morphometric analysis.
Results. In the result of the experiment, pronounced macro- and microscopic alterations of mammary glands were found. Microscopic picture was similar to that observed in fibrocystic mastopathy in women. Almost all the morphometric parameters underwent reliable alterations in correspondence with the given pathology.
Conclusion. A model of fibrocystic disease of mammary gland was obtained that may be used for further study of morphogenesis and methods of correction.
429-436
Interrelation between the system markers of hemostasis and hemocoagulation disorders in patients with tuberculosis in respira-tory organs and comorbid diabetes mellitus after surgical interven-tion on respiratory organs
摘要
The relevance of the work is determined by the necessity to study the markers of the coagulation system of blood and hemocoagulation disorders in patients with pulmonary tuberculosis and comorbid diabetes mellitus in different stages of the postoperative period.
Aim. This study was conducted to identify the interrelation between the system markers of hemostasis and the signs of intravascular blood coagulation development in patients with pulmonary tuberculosis and comorbid diabetes mellitus (TB-DM) in terms of the volume of surgical intervention on respiratory organs.
Materials and Methods. The extent of changes in the system markers of hemostasis was determined in 89 patients with TB-DM before and after surgical treatment. The following parameters of the blood coagulation system were measured: concentration of fibrinogen, level of soluble fibrin–monomer complexes, compensatory potential of fibrinolysis level, activities of the fibrinolytic and anticoagulation systems (antithrombin III). The parameters of prothrombin activity were also studied. The operation material of the lungs was prepared for morphological examination.
Results. The parameters of the hypercoagulation syndrome increased in all the study groups from days 3 to 5 and reached the maximum on days 7 to 10 and 14 to 17 of the postoperative period. The compensatory activation of the fibrin-stabilizing factor and the fibrinolytic system was also observed. The most prominent changes in the hemostasis markers were found in the group of patients after lobectomy. Microthrombotic lesions of the vessels of pulmonary microcirculation with a partial or complete obturation of the lumen were morphologically visualized.
Conclusion. Hypercoagulation syndrome with intravascular blood coagulation was observed in this category of patients. This finding indicated that thromboembolic complications require timely prevention and treatment. This study may be used as a basis for developing measures that can prevent hemocoagulation complications in patients with TB-DM after surgical treatments.
437-448
Morphological and immunohistochemical parameters of chron-ic placental insufficiency in preeclampsia
摘要
Aim. To determine the morphological parameters of chronic placental insufficiency in pregnancy complicated by preeclampsia and in women with chronic arterial hypertension (CAH).
Materials and Methods. Historical data and peculiarities of pregnancy and childbirth in women with hypertensive disorders were analyzed in this work. A review histology of 40 placentas in moderate preeclampsia, 40 placentas in severe preeclampsia, and 35 placentas of women with CAH and associated preeclampsia was performed. The control group consisted of 20 placentas of women with uncomplicated pregnancies and without hypertensive disorders. Immunohistochemical examinations were performed on paraffin sections according to standard methods using primary goat antibodies to annexin V (R-20, sc-1929) and rabbit antibodies to erythropoietin (H-162, sc-7556) in a working dilution of 1:200 with the Super Sensitive IHC polymer detection system.
Results. The results of the pathomorphological examination of the placentas of women with hypertensive disorders showed two forms of chronic placental insufficiency. The defining form of placental insufficiency in women with CAH and associated preeclampsia was fetoplacental insufficiency while that in preeclampsia of moderate and high severity was the uteroplacental form of chronic placental insufficiency. On the basis of the study of the dynamics of the expression of annexin V and erythropoietin, the morphological parameters of placental compensatory potential and placental hemostasis disorders in hypertensive disorders in pregnant women were determined.
Conclusion. The diagnostic morphological criteria for fetoplacental insufficiency in women with hypertensive disorders are a combination of maternal and fetal malperfusion with obliterative angiopathy of stem villi vessels. For the uteroplacental form, the criteria are the obliterative angiopathy of spiral arteries, placental hypoperfusion with the development of local hypoxia, and hemostatic disorders in the form of thrombosis of the intervillous space and villi infarcts.
449-461
Status and dynamics of parameters of use of bed capacity of oncological profile in Russian Federation
摘要
In the Russian Federation (RF) a steady growth of morbidity with oncologic diseases is
observed. An important factor of reduction of negative influence of oncopathology on the
parameters of public health is provision of the population with specialists and beds of oncological profile, as well as their effective use.
Aim. To determine the status and identify dynamics of the main parameters of use of beds
of oncological profile of the state healthcare system of RF, federal districts and constituent entities of RF in comparison with tendencies of parameters of morbidity with malignant neoplasms,
and also of provision of the population with medical personnel in the period from 2010 to 2019.
Materials and Methods. Using the data of the Federal statistical observation forms (№30, 47, 14LC, 7) based on the calculation of absolute and relative parameters by the descriptive statistics method, the analysis of the main parameters of the use of bed resources of «oncology» profile was carried out in comparison with the parameters of morbidity with malignant neoplasms and provision of the population with medical personnel in 24-hour and day-stay hospitals in the Russian Federation, federal districts and constituent entities of the Russian Federation in 2010-2019.
Results. During the study period, with the underlying increase in the morbidity of the
population with diseases of «neoplasm» class (primarily, malignant) in the Russian Federation, there was found a regular increase in: the absolute number of oncological beds for 24-hour stay by 5.216 beds (+16.8%), provision with these beds from 2.17 to 2.47 per 10 000 population (+13.8%), hospitalization rate from 6.1 to 9.6 per 1000 population (+57.4%); and a decrease
in: average stay in an oncological bed by 3.7 days (-30.6%, from 12.1 to 8.4 days), and the
average bed occupancy by 15 days per year (-4.3%, from 345 to 330 days). Mortality in cancer beds increased from 0.76% in 2010 to 0.95% in 2019 (by 25.0%). There was an increase in the provision of the population with oncological beds in day-stay hospitals – by 3.4 times, in day-stay hospitals of polyclinics – by 63.6%.
Conclusion. With the underlying growth of oncological morbidity in the country, the bed capacity of the oncological profile of 24-hour and day hospitals has significantly increased, with a high level of disproportional development of the bed capacity both between federal districts and between the subjects of the Russian Federation.
462-478
ST段心肌梗死患者各种原因的死亡率因再灌注治疗类型而异（RYAZAN地区数据，2018-2020）
摘要
目的：评估ST段抬高型心肌梗死（STEMI）患者的死亡率和全因死亡率，这取决于再灌注治疗的类型。
材料与方法1456例ST段抬高型急性冠脉综合征住院患者中，随机抽取848例进行分析。关于终点（任何原因造成的死亡）的信息收集持续了18个月。目前的数据截至2020年10月1日，随访的中位数为20.8 [17.4; 23.6]个月。
结果。未接受再灌注治疗的患者中，18个月死亡率最高（42.3%）。同时溶栓治疗（TLT）组和未进行再灌注的组在30天内的死亡率没有显着差异（20.3％vs 26.2％，p> 0.05）。经皮冠状动脉介入治疗（PCI）组的住院30天，12个月，18个月全因死亡率分别为8.4％，10.6％，16.6％和18.3％，与对照组相比明显降低。未接受再灌注的患者（分别为19.5％，26.2％，36.2％和42.3％，p <0.05）。达到18个月里程碑时，终点频率的差异最显著：在未再灌注的个体组中，致死率为42.3%，高于TLT组（27.1%）、PCI组（18.3%）和TLT+PCI组（13.1%）。
结果。8个月的随访中，药物介入治疗组和直接PCI组的各种原因的死亡率最低，未接受再灌注治疗组的死亡率最高。
479-487
阻塞性和非阻塞性冠状动脉病变心肌梗死患者内皮功能、血管壁弹性及其对年预测的影响
摘要
目的：比较分析阻塞性和非阻塞性冠状动脉疾病（CA）合并心肌梗死（MI）患者的内皮功能（FE）、血管壁弹性及其对年预后的影响。
材料与方法。第一阶段，选择206例诊断为心肌梗死的患者，其中103例非阻塞性冠状动脉疾病（IMBOCA）患者和103例心肌梗死合并阻塞性冠状动脉疾病（IMOCA）患者。通过随机方法选择59例患者（第一组34例，第二组25例），评估了动脉壁的FE和弹性。基线检查时，两组患者在年龄、性别、临床记忆特征以及影响预后的主要药物组的使用频率方面具有可比性。对这两类患者的年度预测进行了研究，这取决于血管壁无功能和形态变化。
结果。MBOCA患者中，在评估FE时，34例IMBOCA患者中有22例（64.7%）振幅闭塞指数（IRA）低于阈值，25例IMBOCA患者中有22例（88.0%，p<0.05）。平均IRA值分别为1.7（1.5；2.3）和1.4（1.2；1.8）（p<0.05）。两组经络间的相移值低于正常值的频率相同（88.2%和88.0%，p>0.05），该指标的平均值比较也未发现有统计学意义的差异。研究组中，计算出的增大指数（AIp75）分别为12.5（9.9；17.9）和18.8（12.9；20.8）（p>0.05）。IMBOCA组82.4%的患者血管壁弹性降低，IMBOCA组100%的患者血管壁弹性降低（p<0.05）。两组患者年内心血管事件发生率差异无统计学意义（p>0.05）。
结果。IMBOCA患者的血管壁功能变化（内皮功能障碍和血管壁弹性降低）在近2/3的病例中得到记录，但是使用IMBOCA的患者其发生频率更高（88.0％）。IMBOCA和IMOKA研究组的年预后没有差异。
488-496
Training of students of higher medical educational institutions in endovideosurgery skills
摘要
Aim. Evaluation of basic skills in endovideosurgery of students of higher medical educational institutions (HMEI) before and after taking an elective course «Basics of Surgical Technique».
Materials and Methods. Basic skills in endovideosurgery were investigated in students
of the General Medicine Faculty before and after taking an elective course «Basics of Surgical Technique» organized on the base of the simulation hall of the experimental surgery and oncology laboratory of Research Institute of Experimental Medicine at Kursk State Medical University.
The training course included the following exercises on box trainers: Peg Transfer, Pattern
Cut, Intracorporal (single interrupted) Suture. After achievement of satisfactory results, final
assessment was conducted in the form of examination in practical skills and abilities on laboratory animals – biological models (Wetlab). Manipulations conducted by students were assessed using Global Operative Assessment of Laparoscopic Skill (GOALS).
Results. The average values of the assessed parameters increased: criteria «manipulations with tissues» from 2.8 to 4.0 points (42.9%), «perception of depth» from 2.4 to 3.6 points (50%), «movement effectiveness» – by 54.5% (from 2.2 to 3.4 points), «bimanual orientation» – by 60% (from 2.0 to 3.2 points). Criterion «independence» increased by 66.7% (from 1.8 to 3.0 points).
Conclusion. After the elective course «Basics of Surgical Technique», all average values
of the studied parameters increased. The results obtained evidence effectiveness of the methods
of training in basics of endovideosurgery within the frames of the elective course, which permits to develop skills in endosurgical technique at the stage of getting higher medical education.
497-505
Clinical reports
罕见血管异常病人成功的外科治疗案例 - 肾下主动脉发育不良
摘要
目的：演示一个罕见血管异常患者的治疗案例 -肾下主动脉发育不良。
以41岁的患者U的临床例子为例有下肢严重缺血，根据临床和仪器数据诊断出腹主动脉发育不全表现出这种疾病的表现，诊断和成功手术治疗这种病理的可能性。
结果。主动脉发育不良的临床表现取决于损伤的局限性和参与肾动脉。最常见的临床症状是高血压和高血压相关症状。同时主动脉增生也可以表现为上肢肥大，加上下肢肌肉发育不良。年龄较大的患者观察到导致下肢临床有意义缺血的动脉衰竭。因此我们所描述的情况下病人已经在下肢缺血性营养性溃疡。如果这些患者不予治疗，继发性高血压和心力衰竭可导致患者早逝。无论疾病的病因如何，外科是目前治疗这种疾病的唯一有效方法。我们的病人的情况下，我们做了一个动脉硬化和他的假肢切除术。这使身体下部的血液流量得以恢复，并最终导致大部营养性溃疡完全愈合和系统性动脉压力正常化。
506-513
A patient with heartburn practicing self-treatment, on an outpatient visit
摘要
More than 40% of adult Russians periodically feel heartburn. Progression of the disease leads to a number of complications shortening patients’ life. However, patients try to cope with problems by themselves, without receiving adequate early treatment. Only when the life quality worsens, which evidences progression of the disease, they turn to a doctor. Success of treatment depends on the level of the patient’s compliance, life-long complete and regular adherence to treatment recommended by the doctor. With this, an outpatient with a chronic disease should provide the most part of the required medical service by himself. However, patients often change the therapeutic measures on their own impairing the result of treatment.
The given below clinical case of patient Zh., 38 years old, with heartburn and existing risk factors of other non-infectious diseases is a typical illustration of the interaction of a general practitioner and an outpatient practicing self-treatment. Facing the situation of necessary regular medical monitoring and life-long complex intervention, the patient uses only easy-to-follow doctor’s recommendations and understandable for him treatment methods.
Conclusion. On an example of this clinical case, a possible necessary and sufficient plan o f informing outpatient is presented containing information of the tactics of his behavior for full realization of medical recommendations. For successful adaptation of an outpatient with chronic health problems and harmonic attitude to the disease, the doctor should be maximally specific about necessary and adequate measures for correction of the patient’s behavior for the fullest realization of therapeutic recommendations. Recommendations should contain understandable information of basic medicinal and non-medicinal therapy in remission (the essential vital stereotypes – work-rest regime, type and regime of nutrition, physical activity and principles of monitoring the condition), of signs of exacerbation and methods of therapy «on demand» and also information of symptoms requiring urgent assistance, of risks of self-treatment, of visiting the doctor in case new or vivid symptoms appear, of the dates of planned examinations by the doctor. These recommendations are not applicable to patients with severe and manifest course of the disease, with disharmonic attitude to the disease, and in case of inadequate organization capacities and low compliance of the patient.
514-524
Improvement of results of surgical treatment of giant hernias of inguinofemoral region by choice of method of hernioplasty (clinical case)
摘要
Aim. Description of a clinical case pf patient K., 71 years old, as an illustration of the possibility to improve treatment of giant hernias in the inguinofemoral region. The patient was hospitalized with the diagnosis: bilateral giant irreducible inguinoscrotal hernia. The specificity of this case was implementation of the operation of hernioectomy from preperitoneal access with prosthetics of the posterior surface of the anterior abdominal wall with polypropylene (prolene) mesh on both sides. In a month after discharge from hospital the condition remained satisfactory, postoperative scar was normotrophic, testicles painless to palpation with a small amount of fluid in the dartos, skin of scrotum contracted.
Conclusion. Hernioectomy from preperitoneal access with prosthetics of the posterior surface of the anterior abdominal wall with polypropylene (prolene) mesh in patients with giant, irreducible and recurrent hernias possesses a number of peculiarities in comparison with traditional methods, since it permits: 1) to fix endoprosthesis to permanent anatomical structures with simultaneous repair of all the defects of the transverse fascia; 2) to operate outside the zone of scar tissue in recurrent hernias; 3) to perform an adequate revision of the organs of the hernial sack in irreducible hernias; 4) to perform operations on patients with distinct comorbid pathology and contraindications to general anesthesia.
525-529
A case of successful surgical treatment of patient with adrenal cyst using 3-d modeling
摘要
Aim. Demonstration of potentials of preoperative planning and implementation of surgical resection in patients with adrenal cysts.
A clinical observation of a successful surgical treatment of a rare pathology – cyst of the right adrenal is presented. The choice of surgical treatment tactics is determined by the size of tumor and clinical presentation of the disease. The surgical treatment was accomplished laparoscopically which permitted to reduce the time of recovery and rehabilitation of the patient. In this clinical observation, the benefit of using 3D-modeling of the surgical area was shown for visualization of topographic and anatomic peculiarities and facilitation of the intraoperative navigation with the help of Avtoplan program developed by Samara State Medical University.
Conclusion. Preoperative 3D-modeling permits to prepare to surgical intervention taking into account individual anatomic peculiarities of a patient, and to determine the optimal volume of the operation.
530-535
Reviews
急性胰腺炎发生的分子遗传学基础
摘要
急性胰腺炎是腹腔最常见的三种疾病之一，其在本组中的平均比例为10-16%。他只承认患有急性阑尾炎和胆囊炎。急性胰腺炎的发病率和死亡率仍然很高。许多研究人员证实，严重的胰腺疾病会随着胰腺的破坏性改变而发展。
目的：对急性胰腺炎的病因、发病机制、分类、诊断及分子遗传学基础的研究文献进行综述。疾病的发展中起作用的因素（饮食失调、胆石症、血管疾病、过量饮酒）被强调。急性胰腺炎的发生机制，取决于疾病的病因，被详细描述，急性胰腺炎的现代分类被描述。保留了一个地方介绍诊断该病的主要方法包括实验室方法和仪器方法。根据对所有重要生理系统的评估，给出了确定患者严重程度的方法的数据。根据现代关于急性胰腺炎发生机制的观点，许多科学家对研究中的疾病的遗传易感性的可能性进行了研究，这为优化治疗和诊断过程开辟了途径。个人和大规模的遗传研究结果在急性胰腺炎的描述。分离某些候选基因的研究，这些候选基因的蛋白产物参与了急性胰腺炎的发病机制。
结果。综合诊断急性胰腺炎的方法，考虑到研究基因中各种突变的鉴定，以及确定高危人群中表观遗传现象的影响，将提高急性胰腺炎预防、治疗和诊断活动的结果。
536-547
静脉血栓栓塞并发症的长期治疗和二级预防
摘要
静脉血栓栓塞并发症（VTEC）是一种急性和时间有限的疾病。然而，VTEC第一次发作后的复发率很高，可能危及生命。深静脉血栓形成（DVT）和肺栓塞（PE）的发生与抗凝治疗（ACT）的应用密切相关。VTEC患者的现代临床管理的一个特点是确定ACT的持续时间。
目的：研究长期抗凝治疗和静脉血栓栓塞并发症二级预防的可能性，根据文献考虑现代药物治疗选择。
Medline和e-library 包括2020年出版物）中进行了文献检索 我们分析了随机临床和观察性研究, 与长期治疗和VTEC VKA的二级预防有关的荟萃分析， 口服抗凝剂（POAC），舒洛地昔和阿司匹林。病理生理和流行病学数据表明，经过抗凝治疗的前6个月大多数患者中，复发性VTEC的风险尚未解决。这种情况下，将抗凝药物无限期延长是有意义的。然而，长期抗凝治疗的限制因素有时是由于长期抗凝导致出血，有时导致死亡。因此，急性发作后的长期治疗时间可根据复发性静脉血栓形成和出血风险之间的平衡使用量表。近年来在VTEC的长期治疗和二级预防方面取得的主要成就已成为POAC，POAC本质上是新的和替代性的药物，使抗血栓药物库的显著扩展成为可能。同时近年来，随着一个严肃的证据基础的出现，舒洛地特已经出现在这类患者的治疗库中，其大出血和临床显著出血的发生率最低。
结果。POAC的安全性、各种药代动力学和给药方案以及近年来积极用于VTEC二级预防的舒洛地特的出现，为POAC提供了一个重要的证据基础，这将使临床医生能够对静脉血栓形成的各种临床变异采取不同的治疗方法，改善治疗结果，考虑评估个体风险和共病，考虑依从性和依从性。
548-566
Protective mechanisms of lungs
摘要
Respiratory system maintains a close contact with the environment and is constantly exposed to numerous pathogenic factors. In response to action of pathogen, different strategies of specific and non-specific defense have been formed: barrier functions of the epithelium, defense reflexes (coughing, sneezing), muco-ciliary clearance, resident and recruited cells, secretion of a number of proteins and peptides with protective functions.
Aim. To systematize modern concepts of the protective mechanisms of lungs on the basis of the data of the relevant literature.
In the work, the mechanisms and clinical significance of muco-ciliary clearance, resident alveolar and recruited macrophages, epithelial cells, neutrophils, lymphocytes and platelets are analyzed.
Conclusion. The presented mechanisms can counteract the action of various pathogenic agents with sufficient effectiveness. However, in some cases an organism develops insufficient, excessive or perverted response to permeation of pathogens. This results in damage to the lung tissue by exogenous agents and/or by self immune system. Knowledge of protective mechanisms realized in the respiratory system, is necessary for understanding pathogenesis of respiratory diseases and for choice of the optimal treatment tactics.
567-577
治疗遗传学：心理治疗的效率如何与基因型相关？
摘要
心理治疗以及临床和心理干预的有效性取决于各种因素：专家的技能和特点；症状的诊断和严重程度；患者/客户的社会和个人特征；心理治疗接触的参数。治疗遗传学是分子遗传学与心理治疗交叉领域的应用研究领域， 它检查了心理治疗干预(无)成功的分子遗传预测因子。
目的：分析和概括治疗遗传学领域的现有研究，证实其对精神病学、心理治疗和临床心理学的理论和实践重要性，讨论现有的局限性和设计相关应用研究的要求。迄今为止已经有可能确定矛盾的，但同时有希望的模式。本文将治疗基因研究的结果系统化完全按照鉴定候选基因的方法。描述了在儿童和成人焦虑和抑郁症心理治疗中发生的基因-环境相关性。本文系统地介绍了主要按照候选基因鉴定方法进行的治疗遗传学研究的结果。规划治疗遗传学研究时，应考虑以下方法，方法和组织方面：实验样品的足够代表性-无论是在社会人口统计学特征方面，还是在诊断和所用治疗方面；对照组的存在；使用评分量表和半结构化诊断访谈来评估受访者的功能；普遍采用评估心理治疗方法结果的方案；全基因组关联搜索方法的应用；保持机密性，并向受访者提供提供心理帮助的最低有效方法。
578-592
药物诱发的精神分裂症和精神分裂症：接触点
摘要
药物滥用的一个最严重的并发症是诱发性精神病。它们的发生频率从5.2％到100％不等，取决于药物的类型。本审查报告提供了关于诱导性精神病和精神分裂症的相似性和差异的相关数据和讨论。讨论了可能的共同致病途径、临床差异的可能性以及在这方面的主要困难。还讨论了将诱导精神分裂症转变为精神分裂症的问题以及区别对待治疗策略的重要性。
593-604
网织红细胞血红蛋白含量：2020年更新
摘要
网织红细胞血红蛋白含量（Hb-ret）是一种实时血红蛋白合成状态有效指标，可用于所有年龄组缺铁和缺铁性贫血的诊断并监测，不论是否存在基础病（包括β-地中海贫血）。Hb-ret检测比骨铁检查侵入性更小，比铁生化检查更便宜，甚至在本地实验室即可实现。本综述主要涵盖了发表于2020年的报告和其他关注使用Sysmex血液分析仪测量Hb-ret的临床应用研究。
605-612
Media Registry Entry of the Federal Service for Supervision of Communications, Information Technology and Mass Communications (Roskomnadzor) PI No. FS77-76803 dated September 24, 2019.