Vol 11, No 1 (2014)

The review considers pathogenetic predisposing factors and specifics of the development of lesion in target organs - the heart, liver, kidneys - in patients with chronic heart failure combined with diabetes mellitus type 2.

Self-attitude is a central attitude of a personality. We offer an approach to studying self-attitude with its complex structure and its important role in the process of psychological adaptation. We use a set of methods combining qualitative and quantitative approaches. It was implemented for 90 patients with chemical addiction. In total it allowed detailed information about selfattitude of patients.

Pathogenetic principles for management of the anterior eye segment hemoperfusion disturbances were developed in certain eye pathologies such as myopia, senile cataract, primary open-angle glaucoma, senile cataract and uveitis. New methods of therapy were suggested for these diseases.

In the course of environmental and hygienic monitoring an assessment of environment contamination (air, soil, groundwater) was carried out in villages Trudolyubiye, Dubovy Ovrag and Tsatsa of the Volgograd Region, in lakes Tsatsa and Sadok in the catchment area of VOJSC Chimprom evaporation pond.

The authors revealed specifics of morphological adaptation of women of different somatotypes to regular physical activity. It was established that female athletes of asthenic and normostenic constitution, regardless of sports specialization, show morphological signs of virilization upon adaptation to regular exercise. At the same time, sportswomen with hyperstenic body build showed no reliable evidence of virilization development. These data suggest that the masculinizing effect of sports on women does not depend so much on the type of sports, but rather on the type of their body build.

Results of endoscopic ultrasonography in the major duodenal papilla, periampullary region and the treatment of patients with a high and moderate risk of bile duct stones are presented.

Data on the structure and incidence of botulism, as well as features of the clinical picture in Volgograd are presented.

Using the monitoring of nitric oxide (FeNO) in exhaled air for a personalized selection of basic therapy in children with uncontrolled atopic asthma allows a faster achievement of long-term clinical control of the disease in a greater number of patients, reduces the number of exacerbations and the dose of bronchodilators sufficient for control, increases the amount of asymptomatic days, as well as leads to a marked reduction in the extent of allergic airway inflammation as for FeNO content.

Approaches to surgical treatment of primary pterygium are described. Determining the clinical form of pterygium (stationary or progressing), especially at the initial stage was proposed as an additional method of investigation using optical coherence tomography of the anterior segment of the eyeball. Depending on the stage and clinical form of disease, indications for surgery of pterygium were refined. We propose a method of surgical treatment of primary pterygium with low rates of relapse.

Experiments showed that glufimet, a new derivative of glutamic acid, at a dose 28,7 mg/kg and the standard drug Phenibut at a dose of 25 mg/kg limit disturbances of hemostasis under conditions of prolonged stress exposure, which is indicated by a decrease in thrombin time, fibrinogen level, degree and aggregation rate of thrombocytes in animals receiving the studied substances. As to the effectiveness of action, Glufimet exceeds Phenibutum or is comparable to it.

The purpose of this study was to examine some factors of pathogenecity of oral microorganisms in humans with generalized gingivitis during anti-inflammatory treatment. A study of some characteristics of oral microorganisms in patients with gingivitis was defined before and after treatment with Sporobacterin liquid probiotic.

The study is devoted to assessing the state of the middle ear structures by using modern nanotechnology methods. We present the results of our own research of the eardrum movements with a laser autodyne and their value in differential diagnosis of ear diseases.

The objective of our work was to study the in vitro and in vivo effect of a new original substance 4-chlorophenyl-2-hydroxy-4-oxo-2-butenoate thiazolineammonium (FS 169) on blood clotting in rabbits and the duration of bleeding in mice. The obtained data indicate that the substance FS 169 is active in the body of rabbits and mice. The substance slows down blood clotting significantly. The duration of the effect produced by FS 169 upon intragastric introduction amounted to 2 hours. Therefore, this material is promising for further in-depth research.

An optimal chromatographic condition of HPLC method of quantitative determination of the adenine derivative VMA-99-82 was developed. This is a highly sensitive and highly selective method and can be quite helpful in bioassays. The method of sample preparation has been adjusted optimally; it does not have any effect on the standard error of quantitative determination.

Concomitant correction of magnesium deficiency in children with uncontrolled asthma can improve the efficiency of basic therapy in achieving asthma control; it shows pharmacoeconomic benefits in reducing the cost of achieving control and the cost per symptom-free day after 12 weeks of therapy

The article considers the findings obtained in a study of myocardial stress in patients with various types of diastolic dysfunction of the left ventricle. We present data of correlation analysis of echocardiography markers of left ventricular diastolic dysfunction, of myocardial stress and natriuretic peptides (NUP) in the studied patients.

The study established that an increase in pulmonary arterial pressure in patients with liver cirrhosis is accompanied by diastolic ventricular dysfunction, extension of the trunk and branches of the pulmonary artery, left atrium, an increase in left ventricular mass, an increase of Tei index.

In patients with arterial hypertension and obstructive sleep apnea syndrome the authors examined the relationship between symptoms of SDB and the data of daily monitoring of arterial pressure, and with the state of renal function. Both groups were matched for age, sex, duration of hypertension, BP and body mass index. It was established that the main group shows more expressed insufficient decrease of BP at night, a more pronounced decrease in glomerular filtration rate and an increase in urinary albumin excretion.

The article presents the results of a study of postnatal development of rat offspring with experimental preeclampsia induced by replacing drinking water by 1,8% sodium chloride solution from the 7th to the 21st day of gestation. Beneficial effect of compound RGPU-242, a new GABA derivative, on the physical development and maturation rate of sensory-motor reflexes in the offspring.

The article analyzes laboratory markers of endothelial dysfunction and systemic inflammation in diabetic and atherosclerotic angiopathy and the possibility of their use for early diagnosis of vascular lesions. It demonstrates their predictive efficiency and diagnostic sensitivity.