卷 7, 编号 1 (2010)

Articles

CONCEPT OF SYSTEMIC INFLAMMATION IN DIABETIC ANGIOPATHY PATHOGENESIS

Babaeva A., Tarasov A., Bezborodova T., Zaharina O.

摘要

Modern pathogenetic concept of angiopathy in diabetes mellitus is discussed in this article. It reports that inflammation is the leading mechanism of atherosclerosis development and progression in diabetes mellitus and that autoimmune reactions take part in the pathogenesis of vascular lesion. The main proinflammatory cytokines are characterized, a mechanism of their involvement in diabetic angiopathy pathogenesis is shown.
Journal of Volgograd State Medical University. 2010;7(1):3-8
pages 3-8 views

CARDIAC LESION IN TYPE II DIABETIC PATIENTS: RISK FACTORS AND MECHANISMS OF DEVELOPMENT

Statsenko M., Turkina S.

摘要

Nowadays the occurrence of diabetes mellitus is on the rise, mostly due to type II diabetes, which causes early incapacitation of working-age people. The mechanisms of lesion of the heart and vessels in patients with diabetes mellitus are still unclear. That is why the issue of cardiovascular diseases in diabetic patients is so urgent in clinical diabetology. A review of literature throws light on the main factors promoting the development of ischemic heart disease in diabetes mellitus type II as well as on the mechanisms of diabetic cardiomyopathy development.
Journal of Volgograd State Medical University. 2010;7(1):9-14
pages 9-14 views

INSUFFICIENCY OF NONSPECIFIC RESISTANCE MECHANISMS AND SPECIFIC HOST-DEFENSE MECHANISMS AS BREAST CANCER RISK FACTOR

Plokhov V., Barsukov V., Chesnokova N., Selezneva T.

摘要

Development of immunodeficiency prior to neoplasia is a factor of insufficient elimination of spontaneously formed malignant cells and, correspondingly, the factor leading to the subsequent carcinogenesis stage, promotion. Methods of non-adjuvant and adjuvant polychemotherapy used nowadays aggravate insufficiency of nonspecific resistance mechanisms and, thereby, alongside with eradicating tumor cells, these methods are a factor of metastasis of tumor cells (they pass to mitosis phase) while prior to polychemotherapy these cells were dormant.
Journal of Volgograd State Medical University. 2010;7(1):15-21
pages 15-21 views

COMMON DISEASE INCIDENCE OF MEDICAL STAFF IN VOLGOGRAD

Birukov S., Shkarin V., Kozhuhova N., Jarygin O.

摘要

The article presents analysis of personnel resources of Volgograd healthcare agencies for the year 2007—2008 is given. Issues of morbidity with temporal disability among medical staff in Volgograd are discussed.
Journal of Volgograd State Medical University. 2010;7(1):22-25
pages 22-25 views

RENIN-ANGIOTENSIN-ALDOSTERON SYSTEM BLOCK: COMPARISON OF THE RESULTS OF COMBINED THERAPY WITH CARDOSTAN IN COMBINATION WITH ENALAPRIL AND WITH DIOVAN IN COMBINATION WITH ENALAPRIL IN PATIENTS WITH THE FIRST DEGREE ARTERIAL HYPERTENSION IN COMBINATION WITH METABOLIC SYNDROME

Frolova E.

摘要

System metabolic effects of combined therapy by cardostan with enalapril in comparison with diovan and enalapril combination were studied. 50 patients with the first degree arterial hypertension in combination with metabolic syndrome were selected. The combined therapy by cardostan with enalapril or diovan with enalapril was administered. In 24 weeks hypotensive effect of both combinations was the same and it allows to achieve targeted blood pressure, but favorable effect on lipid profile was influenced by the combination of cardostan and enalapril. The unfavorable effect on serum creatinine index was revealed in combined use of diovan and enalapril.
Journal of Volgograd State Medical University. 2010;7(1):26-28
pages 26-28 views

PHARMAECONOMIC ANALYSIS OF THE EFFICACY OF COMPLEX THERAPY FOR TYPE II DIABETIC PATIENTS

Petrov V., Rogova N., Mikhailova D.

摘要

One of the ways to optimize drug therapy in diabetes mellitus is rationalization of the expenses required to treat the patients when applying the standards of type II diabetes management used by endocrinologists. Pharmaeconomic analysis shows that treatment expenses and the extent of drug therapy for type II diabetic patients will significantly rise if strict compliance with pharmacotherapy standards is not achieved.
Journal of Volgograd State Medical University. 2010;7(1):28-32
pages 28-32 views

MORPHO-FUNCTIONAL PROFILE AND SOMATOTYPE OF DRAFTEES IN VOLGOGRAD REGION

Mandrikov V., Krayushkin A., Limanskaua N., Tsarapkin L.

摘要

The paper presents findings of anthopometrical, functional and somatotype parameters of draftees of the Volgograd region.
Journal of Volgograd State Medical University. 2010;7(1):33-34
pages 33-34 views

PHARMACOECONOMIC ANALYSIS OF EFFICIENCY OF ANTIARRHYTHMIC THERAPY WITH BETA-ADRENOBLOCKERS IN CONSTANT FORM OF ATRIAL FIBRILLATION

Makljakov J., Bitsuev V., Shardanov N., Sokolov O., Horonko V.

摘要

Data of pharmacoeconomic analysis of cardioselective beta-adrenoblockers (BAB) are presented, efficiency and safety of metoprolol succinate, nebivolol, bisoprolol for the long control of frequency of atrial contractions (FAC) in patients with constant form of atrial fibrillation (AF) are demonstrated. From pharmacoeconomic point of view bisoprolol can be regarded as a drug of choice among cardioselective beta-adrenoblockers of prolonged action for prolonged therapy of patients with AF.
Journal of Volgograd State Medical University. 2010;7(1):35-37
pages 35-37 views

THE INFLUENCE OF GYMNEMA ACIDS ON CELL DEATH AND REPARATION OF р-CELLS ON STREPTOZOTOCIN-INDUCED DIABETES MELLITUS

Pisarev V., Snigur G., Spasov A., Voronkova M., Bulanov A.

摘要

Inoculation of Gymnema acids extract prevents damage of pancreatic islets of р-cells in models of streptozotocin-induced diabetes mellitus. Gymnema acids partially inhibit apoptosis and increase regeneration of р-cells.
Journal of Volgograd State Medical University. 2010;7(1):38-40
pages 38-40 views

MODERN CLINICAL, INSTRUMENTAL AND MORPHOFUNCTIONAL ASPECTS OF THE COURSE OF INFLAMMATORY PARODONTAL DISEASE IN PATIENTS WITH NAD-GASTROPATHY

Haikin M., Osadchuk M.

摘要

We determined the specifics of the course of inflammatory parodontal diseases in patients with NAD-gastropathy. The study established that chronic gingivitis and chronic parodontitis are more persistent when accompanied by NAD-gatsropathy. Helicobater infection causing a disorder of cellular regeneration of epitheliocytes in oral and gastric mucosa is one of the factors of the onset and development of both parodontal inflammation and NAD-gastropathy. Elimination of Helicobacter pylori in patients with the above-mentioned mixed disease has a positive impact on remission of both chronic gingivitis and chronic parodontitis.
Journal of Volgograd State Medical University. 2010;7(1):41-44
pages 41-44 views

USE OF ANALYTIC NETWORK PROCESS IN FORECASTING OCCURRENCE OF DENTAL DISEASES

Radyshevskaya T., Andreichicova O.

摘要

The article describes implementation of Analytic Network Process into modeling of the impact of various factors on the health status of the oral cavity. The model based on the expert knowledge makes it possible to reveal the factors which can have a noticeable effect on the health status of the system of the body in question in the conditions of mutual influence onto a health status of the body system being examined. The findings are consistent with the observed data. The proposed approach can be used in research and forecasting of the health status of the human organism as a whole.
Journal of Volgograd State Medical University. 2010;7(1):44-47
pages 44-47 views

BENCH TESTS OF INTERNAL STRESS OSTEOSYNTHESIS OF DIAPHYSIS FEMORAL SEGMENT USING CLAMPS WITH THERMOMECHANICAL MEMORY

Svetashov A.

摘要

We analyzed bench tests of the strength of osteosynthesis with the use of clamps with thermomechanical memory 64 of the femur obtained from the corpses of people who died at the age of 30—56. The findings showed a multiple increase (in our case 15—20 times) in the resistance to stress in tension and torsion strapped to the pin bone fragments. Also it was found that if you install compress staple legs through both cortical layers of the femur, femoral fixation increases 1,5 times in comparison with involvement of only one cortical layer
Journal of Volgograd State Medical University. 2010;7(1):47-50
pages 47-50 views

PROGNOSIS, DIAGNOSIS AND CONTROL OF EFFECT OF THERAPY OF CHRONIC PLACENTAL INSUFFICIENCY BY LIPID PEROXIDATION TESTS AND BLOOD ANTIOXIDATION SYSTEM CHECKING

Clemente Apumaita H., Murashko A., Sidorova I., Pak S., Grechkanev G., Dvoryanskiy S., Iutinskiy E.

摘要

140 pregnant females with 24—36 weeks gestation age were examined. Every female was diagnosed by lipid peroxidation (LPO) tests, blood antioxidation system checking. The women at high risk of placental insufficiency immediately showed abnormal findings. When there was a kind of compensation of placental insufficiency, the laboratory findings were worse. The third group (decompensation of placental insufficiency) of pregnant females demonstrated the worst results. We consider the controlling of LPO and antioxidation values in pregnant females to be an adequate method for prognosis of development of placental insufficiency. Using the same figures we could control the severity of the process or effectiveness of therapy (ozonotherapy, hyperbarotherapy etc). Ozonotherapy is a most effective method of correction of LPO in patients with chronic placental insufficiency (a kind of compensation).
Journal of Volgograd State Medical University. 2010;7(1):51-53
pages 51-53 views

HEMODYNAMICS AND ENDOTHELIAL FUNCTION IN ADOLESCENTS WITH HIGH NORMAL BLOOD PRESSURE

Volchansky E., Statsenko M., Snigur E.

摘要

This study focused on central hemodynamics and endothelial function in 49 adolescents with high normal blood pressure. 68 % of patients revealed an increased vascular tone. In this group of patients a marked endothelial dysfunction and prevalence of hypokinetic type of hemodynamics were revealed. 32 % of the adolescents studied revealed a hyperkinetic type of blood circulation accompanied by normal and decreased vascular tone. These findings indicated that adolescents with elevated vascular tone and endothelial dysfunction are at risk of developing primary arterial hypertension.
Journal of Volgograd State Medical University. 2010;7(1):54-56
pages 54-56 views

РREVALENCE OF DENTO-ALVEOLAR ANOMALIES, DEFORMITIES AND DEFECTS OF PRONUNCIATION IN CHILDREN

Vodolatski V., Solomatina G.

摘要

The purpose of the research was to reveal the prevalence of Dento-alveolar anomalies, deformations and defects of pronunciation in 609 children of Stavropol in the age group of 9—15 years. Dento-alveolar anomalies and deformations are revealed in 336 children — 55,17 ±2,71 % and defects of pronunciation are found out in 273 children — 44,83 ±3,01 %.
Journal of Volgograd State Medical University. 2010;7(1):56-59
pages 56-59 views

IMBALANCE OF PROINFLAMMATORY CYTOKINES IN PATIENTS WITH ISCHEMIC HEART DISEASE

Chernova S., Plohov V.

摘要

In ischemic heart disease the level of proinflammatory cytokines IL-1 p, IL-6 and FNO-а is increased. In acute myocardial infarction the highest possible levels of proinflammatory cytokines are noted. In patients with multivascular lesion of coronary arteries the level of cytokines was higher than in patients with a lesion 1—2 main arteries. Patients with high levels of IL-6 and TNF-а, even in hemodynamically insignificant stenoses of coronary arteries, should be ranked as a group of high risk of an adverse outcome of ischemic heart disease.
Journal of Volgograd State Medical University. 2010;7(1):59-62
pages 59-62 views

PREVENTION AND TREATMENT OF ADHESIVE DISEASE OF SMALL PELVIS IN TUBOPERITONEAL INFERTILITY

Tkachenko L., Mikhin I., Minaeva E.

摘要

The paper describes the results of treating 49 patients with tuboperitoneal infertility and adhesive disease of small pelvis where we performed reconstructive surgery of small pelvis with minor access technique using antiadhesive barrier drugs Spraygel, adepta, Mesogel. The patients were divided into two groups according to the rate of acetylation reaction: those with fast acetylation phenotype (N-1) and those with retarded acetylation phenotype (N-2). All patients were also divided into four groups according to the extent of adhesive process. We discuss the possibilities of laparoscopic adhesiolysis in adhesive disease of small pelvis in tuboperitoneal infertility, the need for antiadhesive barrier drugs according to acetylation phenotype. We follow remote results of surgery after treatment of adhesive disease of small pelvis using antiadhesive barrier drugs for up to three years.
Journal of Volgograd State Medical University. 2010;7(1):63-66
pages 63-66 views

GUIDELINES OF POSTOPERATIVE PAIN MANAGEMENT IN THE VOLGOGRAD REGION

Kazantsev D., Ekstrem A., Popov A.

摘要

Implementation of the guidelines of postoperative pain management based on the concept of multimodal analgesia helped along an improvement of the quality of postoperative analgesia in hospitals of Volgograd. However, modern requirements for quality of life and health force one to seek new approaches to the guidelines. One of the proposed options is individualization of the guidelines of postoperative pain management based on a study of the pain threshold.
Journal of Volgograd State Medical University. 2010;7(1):67-69
pages 67-69 views

MEDICAL AND SOCIAL ASPECTS OF ASSOCIATED OCCURRENCE OF HIV-INFECTION AND CHRONIC VIRAL INFECTIONS

Ioannidi E., Chernyavskaya O., Makarova I., Timonova M.

摘要

Features of associated occurrence of chronic viral infections (chronic hepatitis C, B, mixed hepatitis В+С, herpes simplex infections) and HIV-infection are considered. It is established that HIV-infection accelerates liver damage in chronic viral hepatitis, especially in people with associated pathological processes (in narcotism, in particular), there is also a correlation between the extent of immunodeficiency and the patient's condition. Herpes simplex infection associated with herpes viruses types I, II as well as HIV-infection often relapses. Its clinical and laboratory changes are expressed and depend on the extent of immunodeficiency. The specifics of the associated course of the above-mentio ned infections require special tactics of managing such patients, providing medical and social aid to them.
Journal of Volgograd State Medical University. 2010;7(1):70-74
pages 70-74 views

EFFECT OF GABA STRUCTURAL ANALOG ON LPO AND ON ACTIVITY OF ANTIOXIDANT ENZYMES IN ISCHEMIC MYOCARDIAL LESION

Perfilova V., Tjurenkov I., Grechko O., Lamtyugin Y.

摘要

The influence of new GABA structural analog on LPO processes and antioxidant system activity in myocardial ischemia lesion has been studied. It is shown that in the group of animals with occlusion of left coronary artery descending branch, which had received RGPU-147 compound intravenously in dose 50 mg/kg, the content of DK, KA and MDA in cytoplasm of the affected cardiac hystiocytes was increased by 116,6; 40 and 40,8 % correspondingly in comparison with tissues of intact myocardial zones, whereas analogous indices in control group increased by 341.6; 118; 61,9%. SOD and GPO enzymes activity as well as the concentration of reduced glutathione in cytoplasm of ischemic myocardial area of animals, which had received RGPU -147 compound, were decreased by 18.1; 11.5 and 32.5% correspondingly, relative to recorded indices of unaffected areas, in control group of animals — by 35,2; 29,7; 52,3 % correspondingly.
Journal of Volgograd State Medical University. 2010;7(1):74-76
pages 74-76 views

AN ATTEMPT TO MOBILIZE AUTOLOGOUS PERIPHERAL STEM HEMOPOIETIC CD34+ CELLS IN MULTIPLE MYELOMA

Kaplanov K., Tregubova L., Klitochenko T., Matveeva I., Momotiuk K., Shipaeva A., Shipaeva A.

摘要

The effectiveness of the CD34-positive cell harvesting in multiple myeloma patients treated with four courses of PAD (bortezomib, adriablastin, dexametasone) was evaluated. As soon as treatment was finished patients were reevaluated. Three patients who had achieved complete or good partial remission received high-doses of cyclophosfamide. Then their bone marrow was stimulated with G-CSF and CD34-positive cells were collected. In all three cases the number of CD34-positive cells harvested was enough for transplantation and bone marrow repopulation. CD34-positive cells counting and cryopreservation were performed in National Centre for Hematology [Moscow]. The results of this work are crucial for introduction of modern programs of intensive treatment of hematooncological patients.
Journal of Volgograd State Medical University. 2010;7(1):77-81
pages 77-81 views

VALUE OF PHARMACOKINETIC TYPING FOR CYP2C9 ACTIVITY TO ENHANCE PHARMACOTHERAPY OF TYPE II DIABETES IN INDIGENOUS PEOPLE OF THE REPUBLIC OF KALMYKIA

Petrov V., Rogova N., Mikhailova D., Ledyaev Y., Serdukova D., Tyaginova O.

摘要

With a view to finding a way to enhance pharmacotherapy for type II diabetic patients in indigenous people of the Republic of Kalmykia there was first carried out a pharmacokinetic typing for CYP2C9 activity with the help of high performance liquid chromatography. The study revealed a high incidence of the phenotypes that characterize reduced CYP2C9 activity in this ethnic group, which allows us to recommend evaluation of the CYP2C9 activity so as to enhance pharmacotherapy by using sulfonylurea derivatives and reduce the risks of developing undesirable drug reactions.
Journal of Volgograd State Medical University. 2010;7(1):81-85
pages 81-85 views

ATORVASTATIN AND HEART RATE DISTURBANCE. VIEW ON THE MECHANISM OF ACTION

Kozlova E., Nemchuk F., Lopatin Y.

摘要

Atorvastatin significantly reduced the odds of developing heart rate disturbance and the incidents of ST depression, also it improve sympatho-vagal balance.
Journal of Volgograd State Medical University. 2010;7(1):86-90
pages 86-90 views

EVALUATION OF THE INDICES OF RIGIDITY OF GREAT ARTERIES USING THE METHOD OF 24-H BP MONITORING FOR EARLY DIAGNOSTICS OF HYPERTENSION IN CHILDREN

Svetlova L., Dergachev E., Anan'eva Y., Zhukova V., Shakhova N., Ledyaev M.

摘要

The paper presents the results of studying the rigidity indices of great arteries, namely the time of pulse transit time (PTT), dp/dt, which were obtained as a result of processing the 24-hour monitoring data using a portable register BPLab. A stable negative correlation between the PTT index and systolic, diastolic, and pulse BP and heart rate in the 24-h dynamics was revealed. The possibility of using the PWP index calculated on the basis of the data of monitoring BP using BPLab MnSDP-3 as an additional rigidity index of great arteries while making clinical and physiological studies was proved.
Journal of Volgograd State Medical University. 2010;7(1):91-93
pages 91-93 views

GENE EXPRESSION FOR DRUG RESISTANCE OF COLIBACILLUS UNDER THE IMPACT OF E-FIELD RADIATION

Pronina E., Shub G., Shvidenko I.

摘要

The paper presents results of studying the effect of e-field radiation at absorption and radiation molecular spectrum of nitrogen oxide (150 GHz) and atmispheric oxygen (129 GHz) on the sensitivity of colibacillus to a number a antibiotics. The experiments performed indicate that irradiation at the given frequencies affects the gene expression of drug resistance.
Journal of Volgograd State Medical University. 2010;7(1):94-96
pages 94-96 views

ENDOGENOUS INTOXICATION IN PATIENTS WITH POSTNECROTIC PANCREATIC CYSTS

Tropins I., Morozov S., Dolgih V., Poluektov V., Ershov A.

摘要

The dependence between intensity of processes peroxide oxidations of lipids and intoxication at patients with postnecrotic pancreatic cysts by means of registration ferrum-induced chemiluminescence and oligopeptids is revealed. These indicators can be a criteria of postnecrotic pancreatic cysts walls formation and development of complications on what the choice of a surgical treatment method of these patients is depended
Journal of Volgograd State Medical University. 2010;7(1):97-98
pages 97-98 views

CLINICAL AND LABORATORY DIAGNOSIS OF ENDOGENOUS INTOXICATION AT PATIENTS WITH SLUGGISH AND CHRONIC INFLAMMATORY DISEASES OF MAXILLOFACIAL REGION

Fomichev E., Ostrovskij O., Kirpichnikov M., Yarygina E.

摘要

67 patients with traumatic osteomyelitis of the mandible and 70 patients with sluggish odontogenous phlegmons were observed. A new complex of clinical and laboratory tests to diagnose endogenous intoxication was proposed. The presence of endogenous intoxication in all clinical cases was revealed. The results of our work testify to necessity of special profound diagnosis to reveal endointoxication and a more adequate treatment of these patients.
Journal of Volgograd State Medical University. 2010;7(1):99-102
pages 99-102 views

MORPHOLOGICAL NEUROPROTECTION PARAMETERS OF RAT BRAIN WITH ISCHEMIA-REPERFUSION

Ponomarev E., Novochadov V., Strepetov N.

摘要

In our research carried out on experimental animals we produced a model of ischemia-reperfusion. We dyed a section of brain tissues with hematoxiline-eosine, Nissl and used immunohistological exposure of expression of NOS1, NOS3, TRAIL. We estimated pathology in parts of brain and the nature of delayed death of neurons (apoptosis) without cerebroprotection and with popular neuroprotectors. Typical cytotoxic (coagulation, picnomorphic and colliquative necrosis of neurons) and vascular (haemostasis, erythropedesis) changes were revealed. A conclusion was made that neuroprotective activity of drugs decreases in the following way: AKF-90-7>Cytoflavin > Enoxifol> Actovegin> Mexidol.
Journal of Volgograd State Medical University. 2010;7(1):103-106
pages 103-106 views

DIAGNOSTICS OF ALGESIC FORMS OF ABDOMINAL ADHESIVE DISEASE

Mikhin I., Beburishvili A., Gushul A.

摘要

The painful form of adhesive illness without dysfunction of an internal at earlier operated patients arises owing to formation of unions in various areas of a belly cavity. A painful syndrome are capable to cause both vistsero-parietalnye, and vistsero-vistseralnye solderings. The laparoscopy including a visual estimation of changes of bodies of a belly cavity, allows to establish presence, character and prevalence of adhesive process in a belly cavity, to exclude presence of other diseases of a belly cavity that facilitates an establishment of the reason of a painful syndrome.
Journal of Volgograd State Medical University. 2010;7(1):106-110
pages 106-110 views

NODULAR GOITER: CURRENT APPROACHES TO DIAGNOSTICS AND TREATMENT

Golbreich V., Kukhtenko J., Golub V., Kosivtsov O., Bublikov A.

摘要

An analysis of current concepts of the causes, diagnostics and treatment of nodular goiter is provided. The authors' data of treatment of patients with nodular formations of the thyroid gland are presented. An algorithm of the patients' management and indications for surgery on nodular euthyroid goiter is formulated.
Journal of Volgograd State Medical University. 2010;7(1):111-115
pages 111-115 views

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