Vol 17, No 4 (2017)

The aim of our work is the theoretical substantiation of the application of heart rate variability method (HRV) in the study of cognitive functions and functional status. We consider the application of various methods of functional diagnostics in the professional selection, screening of the functional status and the study of cognitive functions among servicemen and specialists of the law enforcement agencies. We write about the physiological mechanisms of the functional status and cognitive functions in the norm, stress, pathology. We analyze the studies of fractal, stochastic parameters of HRV. We propose to include electrophysiological methods (HRV) in cross-validation studies of psychodiagnostics.

Disrupting the synthesis of thyroid hormones (TG) and endothelial dysfunction (ED) have a significant impact on neurovegetative regulation of heart rhythm and hemodynamic at patients suffering with arterial hypertension (AH), a major risk factor for cardiovascular diseases. Objective: to study the features of influence of TG, the metabolites of nitric oxide (NO) on the indices of heart rate variability and their relationship at healthy individuals and patients suffering with AH. Materials and methods. 185 indigenous people in the highlands of Elbrus region (2200 - 3100 m. above sea level) were surveyed: 115 patients suffering with arterial hypertension of different degrees and 70 healthy persons. All examined patients underwent clinical, instrumental and biochemical examinations, including conducting and evaluating heart rate variability (HRV), determination of thyroid hormones, thyroid stimulating hormone, and stable metabolites of nitric oxide in blood components. Results. The obtained results were systematized by means of factor analysis and multiple regression equations. Dependences of absolute and relative values of indicators and indices of HRV on the concentration of TG and NO metabolites in the blood were obtained. The analysis of the most significant factor signs has allowed to show that metabolism TG and NO is closely connected with the adaptation capabilities of the organism both at healthy persons and at hypertensive patients living in the highlands. Conclusion. The obtained data truly indicate the higher stress of regulatory systems of cardiac rhythm and hemodynamic in hypertensive patients with reduced TG synthesis and decrease in NO concentration in blood.

The aim of the research was to study the metabolism of iron at patients with co-infection: tuberculosis of the respiratory organs and chronic hepatitis C. Simple randomized research. The main group consists of patients suffering with chronic viral hepatitis C and respiratory tuberculosis (n=71). The control group consists of patients with respiratory tuberculosis (n=128). The main indicators of hemogram, iron metabolism and acute phase proteins were defined. Indicators in the groups were assessed using the nonparametric Mann-Whitney test. Among the patients in the control group, anemia was detected at 25% of the patients. In the experimental group this rate amounted to 26.7%. In the main group, there was a statistically significant difference in the mean volume of erythrocytes, higher values of ferritin, serum iron, and value of saturation of transferrin with iron in per cents. In the case of chronic forms of tuberculosis in the control group, the concentration of hemoglobin decreased, reticulocytosis appeared, serum iron concentration and percentage of saturation of transferrin by iron decreased. In the experimental group, these indicators remained at a high level. The differences in the groups were statistically significant. At patients suffering with chronic v iral hepatitis C and respiratory tuberculosis, a more frequent progression of anemia in chronic form of the disease was detected, followed by a tendency to overload the tissues with iron. At the same time, among patients with chronic forms of tuberculosis and hepatitis, much less cases of anemia appear.