Vol 11, No 4 (2014)

The article reviewed the explanatory statement of Roszdravnadzor of the key aspects of the fulfillment of the law requirements for drug safety monitoring by health organizations. It provided recommendations on how to effectively identify drug safety problems.

As the problem of drug and psychotropic substance abuse is steadily getting worse, it has become a top-priority objective to meet the needs of patients for analgesic therapy, to improve their quality of life and at the same time to prevent illicit trafficking of dangerous substances.

Risk factors for cerebral palsy were revealed and analyzed. The criteria for predicting cerebral palsy in infants were identified. An evaluation scale aimed at improving care for infants with cerebral palsy was developed.

Effectiveness of physical education of students of the specialized educational department is determined by the teaching technique based on adequacy of the physical exercises in use to the functional state of the body.

The article presented the structure of early postoperative complications in children after congenital cataract aspiration with IOL implantation. The minimal age of the children was 6 years and maximum age was 14 years at the moment of operation. Immunocytochemical indices showing the risk of early postoperative complications were revealed.

Analysis of subjective evaluation of glaucoma significance in all of the studied patients' cohorts revealed that it is subject to the negative impact of such factors as advanced stage of the disease, old age, administration of out-of-date hypotensive medications and more invasive surgical IOP-lowering procedures.

The study provides the findings on the dynamics of biometals (zinc and copper) in patients with acute coronary syndrome depending on the depth of injury of the myocardium. The concentration of zinc in serum in all groups of patients with ACS on admission were statistically significantly lower, and that of copper was higher as compared to the control group. These changes were proportional to the degree of myocardial damage and are most pronounced in patients with Q-formative myocardial infarction.

The article provided a description of a case of gun shot injury. The cause of death as well as the time of the head gunshot wound infliction was identified.

A forensic examination of a male corpse who was found suspended from a 75-meter-high electricity pylon was performed. The data on examination and documentation of the crime scene, the circumstances of the event, postmortal forensic findings as well as the results of the crime laboratory investigation proved it to be a hanging suicide.

We analyzed prescription drug therapies for the prevention and treatment of osteoporosis in a total of 234 case records of osteoporosis in- and outpatients between 2010 and 2013. We interviewed 397 health care professionals employed in a variety of medical fields in Volgograd and in the Volgograd region to identify the degree of their awareness of prescription drug therapies for the prevention and treatment of osteoporosis. Rheumatologists and endocrinologists appeared to be better informed about prescription drug therapies for the treatment of osteoporosis than any other health care professionals. Gynecologists appeared to be ill-informed. Most often therapeutists and traumatologists prescribe Alpha D3-teva, Miacalcic and calcium supplements to treat osteoporosis, although bisphosphonates are considered to be the first-line therapy for osteoporosis. Prescriptions made by rheumatologists and endocrinologists were consistent with clinical practice guidelines for the treatment of osteoporosis.

The article presented the findings of a comparative analysis of nasopharyngeal cultures sampled from healthy children. The patients were divided into two groups according to the anthropogenic impact of the district of residence. Two different anthropogenic areas revealed the same microbial flora of the nasopharynx. The quantitative methods demonstrated a higher bacterial content in the nasopharynx of children residing in a more environmentally friendly area.

Alimentary Mg deficiency induced structural changes in all layers of the uterus and, to a lesser extent, in the ovaries of rats. The structural changes were accompanied by significant deviations of quantitative morphological parameters suggesting increasing predominance of circulatory diseases and atrophic processes. Mg taurinate increased the height of exocrinocytes, the proportion of nuclei in exocrinocytes as well as endometrial and myometrial thickness.

An analysis of the epidemiology of tuberculosis in children and adolescents between 2002-2013 was performed. It showed that tuberculosis morbidity in children residing in the Volgograd region is lower than that in the Russian Federation. However, tuberculosis incidence in an adolescent cohort remains quite high. Continuous collaboration between phthisiatricians and children's health outpatient providers could reduce tuberculosis incidence among adolescents.

The purpose of the present study is to evaluate the comparative microbiological efficiency of polycatan gel in combination with lincomycine 1% and Sporobacterin liquid probiotic in the treatment of inflammatory periodontal diseases. A modified polycatan gel in combination with lincomycine 1% and Sporobacterin liquid probiotic were applied along with the conventional therapeutic strategy in patients with chronic inflammatory periodontal diseases.

The article describes a case report of a complex rehabilitation of a patient with congenital unilateral cleft upper lip and palate. An integrated approach to the treatment of congenital unilateral cleft upper lip and palate involves good cooperation between healthcare professionals, patient compliance and parental involvement in unilateral cleft upper lip and palate treatment.

The aim of the study is to measure the impact of fetal hypoxia on mitochondrial heterogeneity and to identify the ways of controlling heterogeneity in the process of ventricular cardiomyocyte mitochondrial formation. The analysis showed that heterogeneity of organelles causes a specific response to hypoxia. High-energy mitochondria seem to be the most sensitive to hypoxia, while low-energy mitochondria are likely to be less sensitive. The intensity of alterations and the severity of compensatory reactions of mitochondria to hypoxia vary through a series of stages of ontogenesis and are different in various parts of the ventricles.

The article describes a mathematical modeling of an experiment. The matrix of extraction processes planning of the aerial Inula species parts was constructed. A number of parameters and factors which make it possible to optimize the extraction process were identified. Variability factors and parameters were determined.

The article reviews dyspeptic symptoms in 8-12-year-olds with upper gastrointestinal tract disorders accompanied by atopic dermatitis and chronic urticaria. Based on morphological and endoscopic data, the location and invasion depth of the gastric and duodenal mucosa were identified.

Nowadays, decreased efficiency of treatment in patients with destructive pulmonary tuberculosis is observed as a result of increased number of drug-resistant types of tuberculosis. Patients who have multiple drug resistance develop the most severe forms of drug resistant pulmonary tuberculosis. One of the ways of increasing the efficiency of therapy is the use of collapsotherapy (artificial pneumothorax and pneumoperitoneum).

The article describes morphological changes in the cerebral cortex neurons in a stress-induced neurodegeneration experimental model accompanied by amiloidogenesis and pharmacological treatment with phenibut. We revealed that in senior rats stress induced neurodegenerative changes in the cerebral cortex neurons resulting in protein metabolic disturbances. These disturbances are characterized by the intra- and extracellular accumulation of amyloid proteins as well as apoptotic neurons. Prophylaxis with phenibut improves microcirculation and prevents degenerative changes in the nerve cells.

The results of hepatoprotective agent market research are presented in the article. Based on these findings, a number of recommendations on developing adequate product range and calculating the expected demand for hepatoprotective agents in the short term were developed. The results obtained in the course of the study help us make sure that the pharmacies are well-stocked with hepatoprotective agents.