Vol 10, No 2 (2013)

The paper presents general overview of the neurogenesis and cerebrovascular disease.

In rats, 24 months of age against the effects of stress revealed pathological changes in the pyramidal layer CA3 area of the ventral hippocampus. The morphological changes of the dorsal hippocampus bear the asymmetric nature in the right and left hemisphere. Immunohistochemical examination revealed more intense staining of mossy fibers stratum lucidum and the increase in the width of immunoreactive zone stratum radiatum CA3 area of the hippocampus of stressed animals.

The authors present new data on the vital structural and functional anatomical organization of human knee joints using CT, magnetic resonance imaging and an original method for determining the biomechanical load to reveal the effect of different axes of the lower extremity on the anatomic and biomechanical parameters of the knee.

It was determined that magnesium containing medicinal composition reduced the area of gastric ulcer in resistant and nonresistant rats. At the same time resistant rats showed a higher Mg 2+ content in red blood cells from Vs and Vp as well as a greater magneuresis in combination with an increased concentration of Ca 2+ in intestinal lymph and in the daily volume of urine. Nonresistant rats showed a decreased Mg 2+ concentration in plasma from Vs and Vp, in lymph from common intestinal lymphatic duct; the daily volume of urine decreases while Ca 2+ concentration of in biological liquids increases.

The article presents results of a study to determine the effectiveness of an integrated technique for prevention and correction of disorders of the musculoskeletal system in medical students based on the physical dynamics of the health development and functional status of students with scoliosis I—II degree in combination with flat feet I—I degree.

A questionnaire of 584 patients with tuberculosis, 92 phthisiatricians and 144 physicians showed that social help in phthisiatry is necessary, but is provided to a limited extent.

The paper presents an analysis of preferences of physicians and pharmacists choosing anti-ARVI drugs for young children, and the factors affecting the choice.

The article is devoted to the significant parameters of professional burnout in state employees. The structure of the burnout syndrome is presented, and interrelationships between the burnout extent, depression and self-rating of health condition are analyzed.

A comparative analysis of the features allergic history, the nature and range of sensitization in preschool children with different phenotypes of wheezing was conducted.

In this study we investigated the relationship between gene VNTR-polymorphism of endothelial nitric oxide synthase, and the level of endothelin-1 in plasma as a marker of endothelial dysfunction in patients with respiratory-cardiac co-morbidity, namely in patients with a combination of COPD + HD, COPD + IHD. We revealed an effect of VNTR-polymorphism on production of endothelin-1 in somatically healthy individuals, patients with mononosology (HD, IHD, COPD) and in patients with combinations of COPD + HD, COPD + IHD. No significant effect of VNTR- polymorphism on the level of endothelin-1 and development of endothelial dysfunction in patients with comorbid combination of COPD + HD was revealed. At the same time it was found that the presence of 4a/4b genotype causes the development of IHD in patients with COPD, and it also promotes overproduction of endothelin-1 in patients with comorbid combination of COPD + IHD, i.e. enhances the severity of endothelial dysfunction.

Radio Frequency ablation of the liver is one of the components of loco-regional therapy including an integrated effect on the tumor; it is recommended by the World Health Organization in management of hepatocellular carcinoma and metastatic lesion of the liver. To determine the working mode and definitive characteristics of the radio frequency impact on the tissue with an experimental use of Cool-tip RF Ablation System generator we examined some parameters of the generator function. Input characteristics include: Power (W), Electric current (I), Electric impedance (Z), Temperature of cooling liquid (T of the liquid), exposure time. Output characteristics are: Temperature, Geometric specification, Histologic specification. The mode and condition of the work of the generator were determined in order to get the maximum values of the cross-section area and volume of tissues of the ablation field with a maximum tissue damage both in the center and at the periphery of the focus. Practical recommendations for the use of a specific model of RFA generator are offered.

The article presents data of a study of prooxidant and antioxidant systems in 79 children, including 49 children with the active stage of pyelonephritis, and 30 healthy children aged from 1 to 17 years. The characteristics of oxidative stress in pyelonephritis, depending on its course, were determined.

The peculiarities of interaction of self-regulation processes of different individuality levels have been studied. It was established that external feedback acts as a trigger organizing the interaction of different levels of self-regulation, and the interrelations occurring between them depend on the qualitative activity specificity. It was also determined that the regulatory functions of the acceptor of action result underlie the processes of the realized behavior regulation, and are subject to their return effects which is in conformity with the principles of the systemic concept of human adaptation.

On the example of 96 nulliparous women we examined the relationship of cytokine levels with the efficiency of treatment with the standard regimen, with the addition of a second stage of treatment, laser therapy, with the inclusion of tampons with balneologic means Elton (gel), and the combination of these effects. We found that the inclusion of balneologic means Elton (gel) for laser therapy photophoresis made it possible to achieve the maximum effect and to bring down all the investigated cytokines to normal values.

In this article we consider the features of clinical and laboratory course of chronic hepatitis C in HIV-infected patients. It is established that chronic hepatitis C as a co-infection of HIV/AIDS, shows features of clinical and laboratory manifestations. An analysis of biochemical indices in patients with chronic hepatitis C has revealed their dependence on the stage of the HIV infection.

The study was devoted to estimation of vasotropic properties of two drugs used in ophthalmologic practice for myopic patients: of а-adrenomimetic irifrin and carbonic anhydraze inhibitor dorzolomide. We studied the effect of the indicated drugs onto the anterior eye segment hemoperfusion: blood pressure in the anterior ciliary arteries, intraocular pressure, perfusion pressure of the eye anterior segment.

Cell-cell communication is vital to proliferation and survival in homeostatic and disease states. This process is regulated by the gap junction family of proteins that utilize connexin subunits to enable communication between adjacent cells. To find out if cell-cell communication was occurring between cells of the same lineage, we used Jurkat cells as a model system.

The article describes the results of practical application of remote screening intended for early detection of glaucoma. The main advantage of this test is to provide access to a quality study of risk factors for glaucoma using a PC for patients without the need for a specialist and without any special hardware requirements or environment.

The statistics, localization and morphology of peritoneal adhesions are discussed in detail in this article. 278 adhesions in 119 cases from 923 autopsies were revealed. An original algorithm for description of peritoneal adhesion morphology was used successfully to increase the evidence-based value of their discovery in forensic medical practice.