Vol 9, No 1 (2012)

This review focuses on the rapidly expanding body of clinical evidence that supports a strong association between nonalcoholic fatty liver disease and the risk of cardiovascular disease. Recognition of the importance of nonalcoholic fatty liver disease and its strong association with the metabolic syndrome stimulated interest in its putative role in the development and progression of cardiovascular disease.

A retrospective analysis of regional cases of non-developing pregnancy showed a 2,3 times increase of this condition within the period from 2003 to 2010; there was also an increase in non-developing pregnancy cases among primiparas. Parameters of inborns' immunity, of cytokines and endotoxin level in blood serum of 38 female patients with non-developing pregnancy (main group) and 32 female patients with threatening miscarriage in early period before 12 weeks (control group) were studied. To evaluate these findings in physiological pregnancy, 30 women who presented for an abortion of unintended pregnancy were tested. The test results showed a stable increase in endotoxin level in blood, proinflammatory cytokines (TNF, IL-1, IL-6) and an inborn immunity mechanism activation (expression Toll 2, Toll 4) among patients with non-developing pregnancy. These data emphasize the importance of chronic infection in the pathogenesis of pregnancy complication.

Immunological parameters in patients with isolated chronic obstructive pulmonary disease (COPD) with a severe course and COPD in combination with bronchial asthma (BA) with a severe course have been examined. Changes in cellular, humoral immunity, phagocytosis, circulating immune complexes, cytokine profile have been presented.

The research included 162 patients with acute pancreatitis of various aetiology treated in the clinic of hospital surgery from 2002 to 2010. To correct the syndrome of intestinal insufficiency 94 (58 %) patients receiving standard therapy were administered presacral multicomponent novocain block. This reduced the risk of development of multiple organ dysfunction from 26 to 20,2 %, infected pancreatitis from 15,4 to 10,8 % and mortality rate from 8,8 to 5,3 %.

In the article we demonstrated two sectional studies of generalized course of cryptococcosis in patients with HIV infection. We marked a similar nature of tissue changes in various organs indicating the generalization of infection, whose etiology was established only after histological examination with special staining techniques.

The result of our study was that among men of advanced age cerebral atherosclerosis was seen most often in men with picnic constitution type. A comparative analysis of morphometric parameters of hippocampus revealed the greatest variability in the length and width of the fingers and feet. Significant morphological changes in the molecular and pyramidal layers of CA1 and CA3 areas of hippocampus were detected.

Results of morphometric study of hepatocytes in an experimental reproduction West Nile fever are proposed in this article (assessment of the area of the nucleus and the square of hepatocytes and their relation to each other).

The educational process and organization of catering in the Medical College and the College of Professional Technology have been evaluated; the risk factors for students ynutrition have been described.

The possession of general cultural competences allows to extend the field of professional orientation and to form a personality which has an excellent moral fibre and is able to master the achievements of fundamental sciences in an extra-national environment.

Data obtained in cross-correlative analysis in the analysis of electroencephalography of children aged 1-3 with minimum cerebral dysfunction are discussed. It indicates a change in the level of activity and electrical stability of cortical part of the central nervous system. It is manifested, for example, in elevated synchronization of cortical activity of the dominating hemisphere.

Methods of prophylactic dental examination and types of treatment-and-prophylactic actions of students on the basis of a rating system are developed.

A survey of 90 pregnant women with premature rupture of amniotic fluid with mature pregnancy (main group) and 30 patients with timely rupture of amniotic fluid (control group) is discussed. Studies have revealed that premature rupture of amniotic fluid while the mother's body was not ready for delivery, increased hormone production and disturbance of vegetative regulation, increased production of IL-1, IL-6 and unstable personal emotional index make the prognosis of outcome delivery for the mother and fetus worse.

Results of health-related quality of life evaluation on patients with systemic connective tissue diseases using SF-36 questionnaire are presented, and factors associated with alterations in quality of life are detected.

New substituted derivatives of 1-(benzyloxymethyl)-5-(arylamino)uracil were synthesized by trimethylsilyl modification of Gilbert-Johnson method. The level of anti-HIV-1 activity of methylated 5-(benzylamino) derivatives depends on the site of methylation: 3,5-dimethylbenzylamino derivatives were found to be more active than corresponding α- or N-methylated isomers.

The article reviews the history of the foundation of the Stalingrad medical institute as well as the destinies of its academic staff members in the hard postwar years. Special attention is paid to the biography of Akim Kuzmitch Martynov, the first director of the institute. The article uses previously unknown archive records.

The analysis of the annual indices of emergency medical services (EMS) for the rural population of Volgograd region is presented. The characteristics of the mobile team staffing plans, the reasons for calling the ambulance, the grounds for calling it are also presented, the time of reaching destination and other indicators are defined.

The significance of sanological motivation in parents as a determining factor for their behavior which in its term influences not only child's convalescence, but also health consolidation is revealed in the paper. The influence of educational level on sanological motivation is under research.